| Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis F Liu, D Lagares, KM Choi, L Stopfer, A Marinković, V Vrbanac, CK Probst, ... American Journal of Physiology-Lung Cellular and Molecular Physiology 308 (4 …, 2015 | 821 | 2015 |
| Evasion of apoptosis by myofibroblasts: a hallmark of fibrotic diseases B Hinz, D Lagares Nature Reviews Rheumatology 16 (1), 11-31, 2020 | 502 | 2020 |
| Cartilage-specific deletion of mTOR upregulates autophagy and protects mice from osteoarthritis Y Zhang, F Vasheghani, Y Li, M Blati, K Simeone, H Fahmi, B Lussier, ... Annals of the rheumatic diseases 74 (7), 1432-1440, 2015 | 447 | 2015 |
| Fibrosis—a lethal component of systemic sclerosis YY Ho, D Lagares, AM Tager, M Kapoor Nature Reviews Rheumatology 10 (7), 390-402, 2014 | 369 | 2014 |
| PPARγ deficiency results in severe, accelerated osteoarthritis associated with aberrant mTOR signalling in the articular cartilage F Vasheghani, Y Zhang, YH Li, M Blati, H Fahmi, B Lussier, P Roughley, ... Annals of the rheumatic diseases 74 (3), 569-578, 2015 | 229 | 2015 |
| Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis D Lagares, A Santos, PE Grasberger, F Liu, CK Probst, RA Rahimi, ... Science translational medicine 9 (420), eaal3765, 2017 | 218 | 2017 |
| Inhibition of focal adhesion kinase prevents experimental lung fibrosis and myofibroblast formation D Lagares, O Busnadiego, RA García‐Fernández, M Kapoor, S Liu, ... Arthritis & Rheumatism 64 (5), 1653-1664, 2012 | 201 | 2012 |
| Selective YAP/TAZ inhibition in fibroblasts via dopamine receptor D1 agonism reverses fibrosis AJ Haak, E Kostallari, D Sicard, G Ligresti, KM Choi, N Caporarello, ... Science translational medicine 11 (516), eaau6296, 2019 | 191 | 2019 |
| Matrix stiffness: the conductor of organ fibrosis A Santos, D Lagares Current rheumatology reports 20, 1-13, 2018 | 178 | 2018 |
| Role of endothelin in the cardiovascular system F Rodríguez-Pascual, O Busnadiego, D Lagares, S Lamas Pharmacological research 63 (6), 463-472, 2011 | 157 | 2011 |
| Glyceraldehyde-3-phosphate dehydrogenase regulates endothelin-1 expression by a novel, redox-sensitive mechanism involving mRNA stability F Rodríguez-Pascual, M Redondo-Horcajo, N Magán-Marchal, D Lagares, ... Molecular and cellular biology 28 (23), 7139-7155, 2008 | 144 | 2008 |
| ADAM10-mediated ephrin-B2 shedding promotes myofibroblast activation and organ fibrosis D Lagares, A Santos, A Franklin, AM Tager, A Pardo, BS Shea, B Wu, ... Nature medicine, 2017 | 141 | 2017 |
| The Rho kinase isoforms ROCK1 and ROCK2 each contribute to the development of experimental pulmonary fibrosis RS Knipe, CK Probst, D Lagares, A Franklin, JJ Spinney, PL Brazee, ... American journal of respiratory cell and molecular biology 58 (4), 471-481, 2018 | 113 | 2018 |
| Mechano-therapeutics: targeting mechanical signaling in fibrosis and tumor stroma DJ Tschumperlin, D Lagares Pharmacology & therapeutics 212, 107575, 2020 | 111 | 2020 |
| Choline kinase as a link connecting phospholipid metabolism and cell cycle regulation: implications in cancer therapy AR de Molina, D Gallego-Ortega, J Sarmentero-Estrada, D Lagares, ... The international journal of biochemistry & cell biology 40 (9), 1753-1763, 2008 | 101 | 2008 |
| LOXL4 is induced by transforming growth factor β1 through Smad and JunB/Fra2 and contributes to vascular matrix remodeling O Busnadiego, J González-Santamaría, D Lagares, J Guinea-Viniegra, ... Molecular and cellular biology 33 (12), 2388-2401, 2013 | 98 | 2013 |
| Senotherapeutics: Targeting senescence in idiopathic pulmonary fibrosis W Merkt, M Bueno, AL Mora, D Lagares Seminars in cell & developmental biology 101, 104-110, 2020 | 89 | 2020 |
| Endothelin 1 contributes to the effect of transforming growth factor β1 on wound repair and skin fibrosis D Lagares, RA García‐Fernández, CL Jiménez, N Magán‐Marchal, ... Arthritis & Rheumatism 62 (3), 878-889, 2010 | 86 | 2010 |
| A FAK/HDAC5 signaling axis controls osteocyte mechanotransduction T Sato, S Verma, CDC Andrade, M Omeara, N Campbell, JS Wang, ... Nature communications 11 (1), 3282, 2020 | 78 | 2020 |
| Lysophosphatidic acid signaling through its receptor initiates profibrotic epithelial cell fibroblast communication mediated by epithelial cell derived connective tissue growth … N Sakai, J Chun, JS Duffield, D Lagares, T Wada, AD Luster, AM Tager Kidney international 91 (3), 628-641, 2017 | 70 | 2017 |
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