| The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics J Hardy, DJ Selkoe science 297 (5580), 353-356, 2002 | 17513 | 2002 |
| Alzheimer's disease: genes, proteins, and therapy DJ Selkoe Physiological reviews, 2001 | 8297 | 2001 |
| The amyloid hypothesis of Alzheimer's disease at 25 years DJ Selkoe, J Hardy EMBO molecular medicine 8 (6), 595-608, 2016 | 6131 | 2016 |
| Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide C Haass, DJ Selkoe Nature reviews Molecular cell biology 8 (2), 101-112, 2007 | 6103 | 2007 |
| Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo DM Walsh, I Klyubin, JV Fadeeva, WK Cullen, R Anwyl, MS Wolfe, ... Nature 416 (6880), 535-539, 2002 | 5662 | 2002 |
| Alzheimer's disease is a synaptic failure DJ Selkoe Science 298 (5594), 789-791, 2002 | 5386 | 2002 |
| Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory GM Shankar, S Li, TH Mehta, A Garcia-Munoz, NE Shepardson, I Smith, ... Nature medicine 14 (8), 837-842, 2008 | 4591 | 2008 |
| Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria B Dubois, HH Feldman, C Jacova, H Hampel, JL Molinuevo, K Blennow, ... The Lancet Neurology 13 (6), 614-629, 2014 | 3871 | 2014 |
| The molecular pathology of Alzheimer's disease DJ Selkoe Neuron 6 (4), 487-498, 1991 | 3790 | 1991 |
| Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to … D Scheuner, C Eckman, M Jensen, X Song, M Citron, N Suzuki, TD Bird, ... Nature medicine 2 (8), 864-870, 1996 | 3661 | 1996 |
| Complement and microglia mediate early synapse loss in Alzheimer mouse models S Hong, VF Beja-Glasser, BM Nfonoyim, A Frouin, S Li, S Ramakrishnan, ... Science 352 (6286), 712-716, 2016 | 2984 | 2016 |
| Amyloid β-peptide is produced by cultured cells during normal metabolism C Haass, MG Schlossmacher, AY Hung, C Vigo-Pelfrey, A Mellon, ... Nature 359 (6393), 322-325, 1992 | 2747 | 1992 |
| Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production M Citron, T Oltersdorf, C Haass, L McConlogue, AY Hung, P Seubert, ... Nature 360 (6405), 672-674, 1992 | 2648 | 1992 |
| Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity MS Wolfe, W Xia, BL Ostaszewski, TS Diehl, WT Kimberly, DJ Selkoe Nature 398 (6727), 513-517, 1999 | 2629 | 1999 |
| Aβ oligomers–a decade of discovery DM Walsh, DJ Selkoe Journal of neurochemistry 101 (5), 1172-1184, 2007 | 2600 | 2007 |
| Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids P Seubert, C Vigo-Pelfrey, F Esch, M Lee, H Dovey, D Davis, S Sinha, ... Nature 359 (6393), 325-327, 1992 | 2404 | 1992 |
| Translating cell biology into therapeutic advances in Alzheimer's disease DJ Selkoe Nature 399 (6738), A23-A31, 1999 | 2354 | 1999 |
| Natural oligomers of the amyloid-β protein specifically disrupt cognitive function JP Cleary, DM Walsh, JJ Hofmeister, GM Shankar, MA Kuskowski, ... Nature neuroscience 8 (1), 79-84, 2005 | 2288 | 2005 |
| Natural oligomers of the Alzheimer amyloid-β protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway GM Shankar, BL Bloodgood, M Townsend, DM Walsh, DJ Selkoe, ... Journal of Neuroscience 27 (11), 2866-2875, 2007 | 2098 | 2007 |
| Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease. KS KoSIK, CL Joachim, DJ Selkoe Proceedings of the National Academy of Sciences 83 (11), 4044-4048, 1986 | 1967 | 1986 |
