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Xolani Henry Makhoba
Xolani Henry Makhoba
PhD Biochemistry
Verificeret mail på unisa.ac.za
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Potential impact of the multi-target drug approach in the treatment of some complex diseases
XH Makhoba, C Viegas Jr, RA Mosa, FPD Viegas, OJ Pooe
Drug design, development and therapy, 3235-3249, 2020
2032020
Comparative Characterization of Plasmodium falciparum Hsp70-1 Relative to E. coli DnaK Reveals the Functional Specificity of the Parasite Chaperone
CM Lebepe, PR Matambanadzo, XH Makhoba, I Achilonu, T Zininga, ...
Biomolecules 10 (6), 856, 2020
252020
Use of a chimeric Hsp70 to enhance the quality of recombinant Plasmodium falciparum s-adenosylmethionine decarboxylase protein produced in Escherichia coli
XH Makhoba, A Burger, D Coertzen, T Zininga, LM Birkholtz, A Shonhai
PLoS One 11 (3), e0152626, 2016
212016
Protein PEGylation: navigating recombinant protein stability, aggregation, and bioactivity
LK Zuma, NL Gasa, XH Makhoba, OJ Pooe
BioMed Research International 2022 (1), 8929715, 2022
192022
Potential impact of the multi-target drug approach in the treatment of some complex diseases. Drug Des Devel Ther 14: 3235–3249
XH Makhoba, C Viegas Jr, RA Mosa, FPD Viegas, OJ Pooe
122020
The capture of host cell’s resources: The role of heat shock proteins and polyamines in SARS-COV-2 (COVID-19) pathway to viral infection
XH Makhoba, S Makumire
Biomolecular Concepts 13 (1), 220-229, 2022
112022
Molecular chaperone assisted expression systems: obtaining pure soluble and active recombinant proteins for structural and therapeutic purposes
XH Makhoba, OJ Pooe, MS Mthembu
OMICS International, 2015
112015
Potential impact of the multi-target drug approach in the treatment of some complex diseases. Drug Des Devel Ther. 2020; 14: 3235–49
XH Makhoba, C Viegas Jr, RA Mosa, FP Viegas, OJ Pooe
6
The role of pyridine derivatives on the treatment of some complex diseases: A review
XH Makhoba
Recent Developments in the Synthesis and Applications of Pyridines, 143-158, 2023
52023
Medicinal plants as a source of natural remedies in the management of diabetes
XHM Zingisa Sitobo, Liberty Tinotenda Navhaya
INNOSC Theranostics and Pharmacological Sciences. 10 (36922), 1885, 2024
3*2024
In Silico Analysis of SARS-CoV-2 Non-Structural Proteins Reveals an Interaction with the Host’s Heat Shock Proteins That May Contribute to Viral Replications and Development
M Yamkela, Z Sitobo, XH Makhoba
Current Issues in Molecular Biology 45 (12), 10225-10247, 2023
32023
In silico evaluation of heat shock proteins reveals an interplay with polyamines as a survival strategy for the Plasmodium falciparum
G Sesethu, M Nombalentle, M Yamkela, M Anelisa, S Makumire, ...
INNOSC Theranostics and Pharmacological Sciences 7 (1), 1228, 2023
32023
A Double Line of Defense: Heat Shock Proteins and Polyamines Act as Contributing Factors to Drug Resistance of some Plasmodium Parasites
XH Makhoba
Plasmodium Species and Drug Resistance, 2021
32021
A comprehensive review of the interaction between COVID-19 spike proteins with mammalian small and major heat shock proteins
LT Navhaya, DM Blessing, M Yamkela, S Godlo, XH Makhoba
Biomolecular Concepts 15 (1), 20220027, 2024
22024
An Undefined Interaction between Polyamines and Heat Shock Proteins Leads to Cellular Protection in Plasmodium falciparum and Proliferating Cells in Various Organisms
E Makhoba, X.H. Ragno, R. Kaiser, Agostinelli
Molecules 28 (4), 1686, 2023
12023
The development of a molecular chaperone-based system to improve the heterologous production of Plasmodium falciparum AdoMetDC protein in E. coli.
XH Makhoba
12011
In Silico Discovery and Evaluation of Inhibitors of the SARS-CoV-2 Spike Protein–HSPA8 Complex Towards Developing COVID-19 Therapeutic Drugs
LT Navhaya, TM Matsebatlela, MZ Monama, XH Makhoba
Viruses 16 (11), 1726, 2024
2024
Biomolecular concepts: A comprehensive review of the interaction between COVID-19 spike proteins with mammalian small and major heat shock proteins
LT Navhaya, DM Blessing, M Yamkela, S Godlo, XH Makhoba
de Gruyter, 2024
2024
A Comprehensive Review of Some Heat‐Shock Proteins in the Development and Progression of Human Breast Cancer
XH Makhoba, OJ Pooe
Drug and Therapy Development for Triple Negative Breast Cancer, 237-247, 2023
2023
Drug Repurposing: Challenges and Successes in the Treatment of SARS-CoV-2
XH Makhoba
Drug Repurposing-Advances, Scopes and Opportunities in Drug Discovery, 2023
2023
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Artikler 1–20