tim bartels

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Dennis SelkoeCo-Director, Ann Romney Center for Neurologic Disases, Brigham and Women's HospitalVerificeret mail på bwh.harvard.edu
Ulf DettmerHarvard Medical School/Brigham and Women's HospitalVerificeret mail på harvard.edu
Eric LuthSimmons UniversityVerificeret mail på simmons.edu
Victoria von SauckenWeill Cornell/Rockefeller/Sloan Kettering Tri-Institutional MD-PhD ProgramVerificeret mail på med.cornell.edu
Michael F. BrownProfessor of Chemistry, Physics, & Applied Mathematics, University of ArizonaVerificeret mail på u.arizona.edu
Frits KampLudwig Maximilian University MunichVerificeret mail på mail03.med.uni-muenchen.de
Matteo RovereUniversity of Turin, Department of Medical SciencesVerificeret mail på edu.unito.it
Soyon HongVerificeret mail på post.harvard.edu
Ming JinAnn Romney Center for Neurologic Diseases, BWH, HMSVerificeret mail på partners.org
Avigdor LeftinStony Brook University School of MedicineVerificeret mail på stonybrookmedicine.edu
Logan S AhlstromData Scientist, TD Ameritrade (Formerly, postdoc at U. Michigan and Howard Hughes Medical Institute)Verificeret mail på tdameritrade.com
Armin GieseCSO, MODAG GmbHVerificeret mail på modag.net
Konstanze WinklhoferRuhr University BochumVerificeret mail på ruhr-uni-bochum.de
Stefan EimerVerificeret mail på bio.uni-frankfurt.de
Xianjun Dong, PhDAssociate Professor, Department of Neurology and of BIDS, Yale UniversityVerificeret mail på yale.edu
Birgitt SchueleAssociate Professor, Stanford University School of MedicineVerificeret mail på stanford.edu
Bruce S. KristalJean Mayer USDA Human Nutrition Research Center on Aging at TuftsVerificeret mail på Tufts.edu
Saranna FanningHarvard Medical School and Brigham & Women's HospitalVerificeret mail på bwh.harvard.edu
Scott SaavedraProfessor Emeritus of Chemistry and Biochemistry, University of ArizonaVerificeret mail på arizona.edu
Peter HeutinkIndependant consultant

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tim bartels

University College London, Dementia Research Institute

Verificeret mail på ucl.ac.uk - Startside

Biochemistry Neurodegeneration Protein folding


Titel Sortér efter henvisninger Sortér efter årstal Sortér efter titel	Citeret af Citeret af	År
α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation T Bartels, JG Choi, DJ Selkoe Nature 477 (7362), 107-110, 2011	1580	2011
Inhibition of mitochondrial fusion by α‐synuclein is rescued by PINK1, Parkin and DJ‐1 F Kamp, N Exner, AK Lutz, N Wender, J Hegermann, B Brunner, ... The EMBO journal 29 (20), 3571-3589, 2010	615	2010
β2-Adrenoreceptor is a regulator of the α-synuclein gene driving risk of Parkinson’s disease S Mittal, K Bjørnevik, DS Im, A Flierl, X Dong, JJ Locascio, KM Abo, ... Science 357 (6354), 891-898, 2017	473	2017
Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation U Dettmer, AJ Newman, F Soldner, ES Luth, NC Kim, VE Von Saucken, ... Nature communications 6 (1), 7314, 2015	355	2015
Soluble, prefibrillar α-synuclein oligomers promote complex I-dependent, Ca2+-induced mitochondrial dysfunction ES Luth, IG Stavrovskaya, T Bartels, BS Kristal, DJ Selkoe Journal of Biological Chemistry 289 (31), 21490-21507, 2014	344	2014
The N-terminus of the intrinsically disordered protein α-synuclein triggers membrane binding and helix folding T Bartels, LS Ahlstrom, A Leftin, F Kamp, C Haass, MF Brown, K Beyer Biophysical journal 99 (7), 2116-2124, 2010	337	2010
Microglia modulate neurodegeneration in Alzheimer’s and Parkinson’s diseases T Bartels, S De Schepper, S Hong Science 370 (6512), 66-69, 2020	331	2020
In vivo cross-linking reveals principally oligomeric forms of α-synuclein and β-synuclein in neurons and non-neural cells U Dettmer, AJ Newman, ES Luth, T Bartels, D Selkoe Journal of Biological Chemistry 288 (9), 6371-6385, 2013	295	2013
Soluble Aβ oligomers are rapidly sequestered from brain ISF in vivo and bind GM1 ganglioside on cellular membranes S Hong, BL Ostaszewski, T Yang, TT O’Malley, M Jin, K Yanagisawa, S Li, ... Neuron 82 (2), 308-319, 2014	238	2014
N-alpha-acetylation of α-synuclein increases its helical folding propensity, GM1 binding specificity and resistance to aggregation T Bartels, NC Kim, ES Luth, DJ Selkoe PloS one 9 (7), e103727, 2014	203	2014
KTKEGV repeat motifs are key mediators of normal α-synuclein tetramerization: Their mutation causes excess monomers and neurotoxicity U Dettmer, AJ Newman, VE von Saucken, T Bartels, D Selkoe Proceedings of the National Academy of Sciences 112 (31), 9596-9601, 2015	196	2015
Familial knockin mutation of LRRK2 causes lysosomal dysfunction and accumulation of endogenous insoluble α-synuclein in neurons J Schapansky, S Khasnavis, MP DeAndrade, JD Nardozzi, SR Falkson, ... Neurobiology of disease 111, 26-35, 2018	139	2018
Raftlike Mixtures of Sphingomyelin and Cholesterol Investigated by Solid-State ²H NMR Spectroscopy T Bartels, RS Lankalapalli, R Bittman, K Beyer, MF Brown Journal of the American Chemical Society 130 (44), 14521-14532, 2008	136	2008
New insights into cellular α-synuclein homeostasis in health and disease U Dettmer, D Selkoe, T Bartels Current opinion in neurobiology 36, 15-22, 2016	110	2016
Purification of α-synuclein from human brain reveals an instability of endogenous multimers as the protein approaches purity ES Luth, T Bartels, U Dettmer, NC Kim, DJ Selkoe Biochemistry 54 (2), 279-292, 2015	98	2015
Loss of native α-synuclein multimerization by strategically mutating its amphipathic helix causes abnormal vesicle interactions in neuronal cells U Dettmer, N Ramalingam, VE von Saucken, TE Kim, AJ Newman, ... Human molecular genetics 26 (18), 3466-3481, 2017	92	2017
Dynamic physiological α-synuclein S129 phosphorylation is driven by neuronal activity N Ramalingam, SX Jin, TE Moors, L Fonseca-Ornelas, K Shimanaka, ... npj Parkinson's Disease 9 (1), 4, 2023	66	2023
Defining the native state of α-synuclein D Selkoe, U Dettmer, E Luth, N Kim, A Newman, T Bartels Neurodegenerative Diseases 13 (2-3), 114-117, 2014	65	2014
Refolding of helical soluble α‐synuclein through transient interaction with lipid interfaces M Rovere, JB Sanderson, L Fonseca‐Ornelas, DS Patel, T Bartels FEBS letters 592 (9), 1464-1472, 2018	52	2018
E46K-like α-synuclein mutants increase lipid interactions and disrupt membrane selectivity M Rovere, AE Powers, H Jiang, JC Pitino, L Fonseca-Ornelas, DS Patel, ... Journal of Biological Chemistry 294 (25), 9799-9812, 2019	47	2019

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