| PINK1-dependent recruitment of Parkin to mitochondria in mitophagy C Vives-Bauza, C Zhou, Y Huang, M Cui, RLA De Vries, J Kim, J May, ... Proceedings of the National Academy of Sciences 107 (1), 378-383, 2010 | 1944 | 2010 |
| Transneuronal propagation of pathologic α-synuclein from the gut to the brain models Parkinson’s disease S Kim, SH Kwon, TI Kam, N Panicker, SS Karuppagounder, S Lee, JH Lee, ... Neuron 103 (4), 627-641. e7, 2019 | 1248 | 2019 |
| PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease JH Shin, HS Ko, H Kang, Y Lee, YI Lee, O Pletinkova, JC Troconso, ... Cell 144 (5), 689-702, 2011 | 1060 | 2011 |
| Genetic animal models of Parkinson's disease TM Dawson, HS Ko, VL Dawson Neuron 66 (5), 646-661, 2010 | 1016 | 2010 |
| Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease SP Yun, TI Kam, N Panicker, SM Kim, Y Oh, JS Park, SH Kwon, YJ Park, ... Nature medicine 24 (7), 931-938, 2018 | 1004 | 2018 |
| Midbrain-like organoids from human pluripotent stem cells contain functional dopaminergic and neuromelanin-producing neurons J Jo, Y Xiao, AX Sun, E Cukuroglu, HD Tran, J Göke, ZY Tan, TY Saw, ... Cell stem cell 19 (2), 248-257, 2016 | 812 | 2016 |
| Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3 X Mao, MT Ou, SS Karuppagounder, TI Kam, X Yin, Y Xiong, P Ge, ... Science 353 (6307), aah3374, 2016 | 748 | 2016 |
| DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase E Andres-Mateos, C Perier, LI Zhang, B Blanchard-Fillion, TM Greco, ... Proceedings of the National Academy of Sciences 104 (37), 14807-14812, 2007 | 589 | 2007 |
| Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseases JMM Tan, ESP Wong, DS Kirkpatrick, O Pletnikova, HS Ko, SP Tay, ... Human molecular genetics 17 (3), 431-439, 2008 | 563 | 2008 |
| Poly (ADP-ribose) drives pathologic α-synuclein neurodegeneration in Parkinson’s disease TI Kam, X Mao, H Park, SC Chou, SS Karuppagounder, GE Umanah, ... Science 362 (6414), eaat8407, 2018 | 461 | 2018 |
| Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease BD Lee, JH Shin, J VanKampen, L Petrucelli, AB West, HS Ko, YI Lee, ... Nature medicine 16 (9), 998-1000, 2010 | 433 | 2010 |
| Graphene quantum dots prevent α-synucleinopathy in Parkinson’s disease D Kim, JM Yoo, H Hwang, J Lee, SH Lee, SP Yun, MJ Park, MJ Lee, ... Nature nanotechnology 13 (9), 812-818, 2018 | 419 | 2018 |
| Sulfhydration mediates neuroprotective actions of parkin MS Vandiver, BD Paul, R Xu, S Karuppagounder, F Rao, AM Snowman, ... Nature communications 4 (1), 1626, 2013 | 342 | 2013 |
| Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function HS Ko, Y Lee, JH Shin, SS Karuppagounder, BS Gadad, AJ Koleske, ... Proceedings of the National Academy of Sciences 107 (38), 16691-16696, 2010 | 316 | 2010 |
| Accumulation of the authentic parkin substrate aminoacyl-tRNA synthetase cofactor, p38/JTV-1, leads to catecholaminergic cell death HS Ko, R Von Coelln, SR Sriram, SW Kim, KKK Chung, O Pletnikova, ... Journal of Neuroscience 25 (35), 7968-7978, 2005 | 291 | 2005 |
| Iduna is a poly (ADP-ribose)(PAR)-dependent E3 ubiquitin ligase that regulates DNA damage HC Kang, YI Lee, JH Shin, SA Andrabi, Z Chi, JP Gagné, Y Lee, HS Ko, ... Proceedings of the National Academy of Sciences 108 (34), 14103-14108, 2011 | 278 | 2011 |
| The c-Abl inhibitor, nilotinib, protects dopaminergic neurons in a preclinical animal model of Parkinson's disease SS Karuppagounder, S Brahmachari, Y Lee, VL Dawson, TM Dawson, ... Scientific reports 4 (1), 4874, 2014 | 261 | 2014 |
| Stress-induced alterations in parkin solubility promote parkin aggregation and compromise parkin's protective function C Wang, HS Ko, B Thomas, F Tsang, KCM Chew, SP Tay, MWL Ho, ... Human molecular genetics 14 (24), 3885-3897, 2005 | 251 | 2005 |
| Familial-associated mutations differentially disrupt the solubility, localization, binding and ubiquitination properties of parkin SR Sriram, X Li, HS Ko, KKK Chung, E Wong, KL Lim, VL Dawson, ... Human molecular genetics 14 (17), 2571-2586, 2005 | 248 | 2005 |
| Mitochondrial dysfunction and mitophagy defect triggered by heterozygous GBA mutations H Li, A Ham, TC Ma, SH Kuo, E Kanter, D Kim, HS Ko, Y Quan, SP Sardi, ... Autophagy 15 (1), 113-130, 2019 | 228 | 2019 |
Ted M. DawsonDirector, Institute for Cell Engineering, Professor of Neurology and Neuroscience, JHUSoMVerificeret mail på jhmi.edu