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Dung Le
Dung Le
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PD-1 blockade in tumors with mismatch-repair deficiency
DT Le, JN Uram, H Wang, BR Bartlett, H Kemberling, AD Eyring, ...
New England Journal of Medicine 372 (26), 2509-2520, 2015
101722015
Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade
DT Le, JN Durham, KN Smith, H Wang, BR Bartlett, LK Aulakh, S Lu, ...
Science 357 (6349), 409-413, 2017
66002017
Detection of circulating tumor DNA in early-and late-stage human malignancies
C Bettegowda, M Sausen, RJ Leary, I Kinde, Y Wang, N Agrawal, ...
Science translational medicine 6 (224), 224ra24-224ra24, 2014
51292014
Efficacy of pembrolizumab in patients with noncolorectal high microsatellite instability/mismatch repair–deficient cancer: results from the phase II KEYNOTE-158 study
A Marabelle, DT Le, PA Ascierto, AM Di Giacomo, A De Jesus-Acosta, ...
Journal of Clinical Oncology 38 (1), 1-10, 2020
26452020
Pembrolizumab in microsatellite-instability–high advanced colorectal cancer
T André, KK Shiu, TW Kim, BV Jensen, LH Jensen, C Punt, D Smith, ...
New England Journal of Medicine 383 (23), 2207-2218, 2020
23982020
Nivolumab alone and nivolumab plus ipilimumab in recurrent small-cell lung cancer (CheckMate 032): a multicentre, open-label, phase 1/2 trial
SJ Antonia, JA López-Martin, J Bendell, PA Ott, M Taylor, JP Eder, ...
The Lancet Oncology 17 (7), 883-895, 2016
13942016
Primary Resistance to PD-1 Blockade Mediated by JAK1/2 Mutations
DS Shin, JM Zaretsky, H Escuin-Ordinas, A Garcia-Diaz, S Hu-Lieskovan, ...
Cancer discovery 7 (2), 188-201, 2017
12492017
Pembrolizumab for patients with PD-L1-positive advanced gastric cancer (KEYNOTE-012): a multicentre, open-label, phase 1b trial
K Muro, HC Chung, V Shankaran, R Geva, D Catenacci, S Gupta, JP Eder, ...
The lancet oncology 17 (6), 717-726, 2016
12022016
Phase II open-label study of pembrolizumab in treatment-refractory, microsatellite instability–high/mismatch repair–deficient metastatic colorectal cancer: KEYNOTE-164
DT Le, TW Kim, E Van Cutsem, R Geva, D Jäger, H Hara, M Burge, ...
Journal of clinical oncology 38 (1), 11-19, 2020
9352020
Microsatellite instability as a biomarker for PD-1 blockade
JC Dudley, MT Lin, DT Le, JR Eshleman
Clinical Cancer Research 22 (4), 813-820, 2016
9252016
Nivolumab monotherapy in recurrent metastatic urothelial carcinoma (CheckMate 032): a multicentre, open-label, two-stage, multi-arm, phase 1/2 trial
P Sharma, MK Callahan, P Bono, J Kim, P Spiliopoulou, E Calvo, ...
The lancet oncology 17 (11), 1590-1598, 2016
7662016
Evolutionary dynamics of cancer in response to targeted combination therapy
I Bozic, JG Reiter, B Allen, T Antal, K Chatterjee, P Shah, YS Moon, ...
elife 2, e00747, 2013
7202013
Safety and Survival With GVAX Pancreas Prime and Listeria Monocytogenes–Expressing Mesothelin (CRS-207) Boost Vaccines for Metastatic Pancreatic Cancer
DT Le, A Wang-Gillam, V Picozzi, TF Greten, T Crocenzi, G Springett, ...
Journal of clinical oncology 33 (12), 1325-1333, 2015
6902015
Clinicopathological features of acute kidney injury associated with immune checkpoint inhibitors
FB Cortazar, KA Marrone, ML Troxell, KM Ralto, MP Hoenig, JR Brahmer, ...
Kidney international 90 (3), 638-647, 2016
6482016
CheckMate-032 study: efficacy and safety of nivolumab and nivolumab plus ipilimumab in patients with metastatic esophagogastric cancer
YY Janjigian, J Bendell, E Calvo, JW Kim, PA Ascierto, P Sharma, PA Ott, ...
Journal of Clinical Oncology 36 (28), 2836-2844, 2018
6352018
Evaluation of ipilimumab in combination with allogeneic pancreatic tumor cells transfected with a GM-CSF gene in previously treated pancreatic cancer
DT Le, E Lutz, JN Uram, EA Sugar, B Onners, S Solt, L Zheng, LA Diaz Jr, ...
Journal of immunotherapy 36 (7), 382-389, 2013
6272013
Pembrolizumab versus chemotherapy for microsatellite instability-high or mismatch repair-deficient metastatic colorectal cancer (KEYNOTE-177): final analysis of a randomised …
LA Diaz, KK Shiu, TW Kim, BV Jensen, LH Jensen, C Punt, D Smith, ...
The Lancet Oncology 23 (5), 659-670, 2022
5672022
DNA mismatch repair in cancer
M Baretti, DT Le
Pharmacology & therapeutics 189, 45-62, 2018
5222018
Genetic diversity of tumors with mismatch repair deficiency influences anti–PD-1 immunotherapy response
R Mandal, RM Samstein, KW Lee, JJ Havel, H Wang, C Krishna, ...
Science 364 (6439), 485-491, 2019
5172019
A lethally irradiated allogeneic granulocyte-macrophage colony stimulating factor-secreting tumor vaccine for pancreatic adenocarcinoma: a phase II trial of safety, efficacy …
L Eric, CJ Yeo, KD Lillemoe, B Biedrzycki, B Kobrin, J Herman, E Sugar, ...
Annals of surgery 253 (2), 328-335, 2011
4562011
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