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Kristine Griffett
Kristine Griffett
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Nuclear receptors and their selective pharmacologic modulators
TP Burris, LA Solt, Y Wang, C Crumbley, S Banerjee, K Griffett, ...
Pharmacological reviews 65 (2), 710-778, 2013
3112013
Broad anti-tumor activity of a small molecule that selectively targets the Warburg effect and lipogenesis
CA Flaveny, K Griffett, BEDM El-Gendy, M Kazantzis, M Sengupta, ...
Cancer cell 28 (1), 42-56, 2015
2092015
A liver-selective LXR inverse agonist that suppresses hepatic steatosis
K Griffett, LA Solt, BEDM El-Gendy, TM Kamenecka, TP Burris
ACS chemical biology 8 (3), 559-567, 2013
1332013
Pharmacological targeting of the mammalian clock regulates sleep architecture and emotional behaviour
S Banerjee, Y Wang, LA Solt, K Griffett, M Kazantzis, A Amador, ...
Nature communications 5 (1), 5759, 2014
1192014
The LXR inverse agonist SR9238 suppresses fibrosis in a model of non-alcoholic steatohepatitis
K Griffett, RD Welch, CA Flaveny, GR Kolar, BA Neuschwander-Tetri, ...
Molecular metabolism 4 (4), 353-357, 2015
952015
The mammalian clock and chronopharmacology
K Griffett, TP Burris
Bioorganic & medicinal chemistry letters 23 (7), 1929-1934, 2013
572013
Promiscuous activity of the LXR antagonist GSK2033 in a mouse model of fatty liver disease
K Griffett, TP Burris
Biochemical and Biophysical Research Communications 479 (3), 424-428, 2016
402016
Mitochondrial pyruvate carrier inhibitors improve metabolic parameters in diet-induced obese mice
WT Hodges, C Jarasvaraparn, D Ferguson, K Griffett, LE Gill, Y Chen, ...
Journal of Biological Chemistry 298 (2), 2022
332022
Fructose promotes cytoprotection in melanoma tumors and resistance to immunotherapy
LM Kuehm, N Khojandi, A Piening, LE Klevorn, SC Geraud, ...
Cancer immunology research 9 (2), 227-238, 2021
272021
REV-ERB agonism improves liver pathology in a mouse model of NASH
K Griffett, G Bedia-Diaz, B Elgendy, TP Burris
PloS one 15 (10), e0236000, 2020
262020
The orphan nuclear receptor TLX is a receptor for synthetic and natural retinoids
K Griffett, G Bedia-Diaz, L Hegazy, IMS de Vera, US Wanninayake, ...
Cell Chemical Biology 27 (10), 1272-1284. e4, 2020
252020
Development of novel liver X receptor modulators based on a 1, 2, 4-triazole scaffold
SS Goher, K Griffett, L Hegazy, M Elagawany, MMH Arief, A Avdagic, ...
Bioorganic & medicinal chemistry letters 29 (3), 449-453, 2019
232019
International union of basic and clinical pharmacology CXIII: Nuclear receptor superfamily—Update 2023
TP Burris, IMS de Vera, I Cote, CA Flaveny, US Wanninayake, ...
Pharmacological reviews 75 (6), 1233-1318, 2023
222023
Development of LXR inverse agonists to treat MAFLD, NASH, and other metabolic diseases
K Griffett, TP Burris
Frontiers in medicine 10, 1102469, 2023
222023
Emerging Role of Nuclear Receptors for the Treatment of NAFLD and NASH
RD Welch, C Billon, MK Losby, G Bedia-Diaz, Y Fang, A Avdagic, ...
Metabolites 12 (3), 238, 2022
192022
The role of REV-ERB in NASH
K Griffett, ME Hayes, MP Boeckman, TP Burris
Acta Pharmacologica Sinica 43 (5), 1133-1140, 2022
172022
Inhibition of hepatotoxicity by a LXR inverse agonist in a model of alcoholic liver disease
M Sengupta, K Griffett, CA Flaveny, TP Burris
ACS pharmacology & translational science 1 (1), 50-60, 2018
172018
A two-hit model of alcoholic liver disease that exhibits rapid, severe fibrosis
M Sengupta, S Abuirqeba, A Kameric, A Cecile-Valfort, A Chatterjee, ...
PloS one 16 (3), e0249316, 2021
112021
Antihyperlipidemic activity of gut-restricted LXR inverse agonists
K Griffett, M Hayes, G Bedia-Diaz, K Appourchaux, R Sanders, ...
ACS Chemical Biology 17 (5), 1143-1154, 2022
92022
REV-ERB activation as a novel pharmacological approach for treating inflammatory pain
S Makhija, JD Griffett, GB Veerakanellore, TP Burris, B Elgendy, K Griffett
Frontiers in pharmacology 14, 1171931, 2023
72023
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Artikler 1–20