| Cysteine proteases and their inhibitors HH Otto, T Schirmeister Chemical reviews 97 (1), 133-172, 1997 | 1085 | 1997 |
| Development of peptidomimetics with a vinyl sulfone warhead as irreversible falcipain-2 inhibitors R Ettari, E Nizi, ME Di Francesco, MA Dude, G Pradel, R Vičík, ... Journal of medicinal chemistry 51 (4), 988-996, 2008 | 252 | 2008 |
| Biochemistry and medicinal chemistry of the dengue virus protease C Nitsche, S Holloway, T Schirmeister, CD Klein Chemical reviews 114 (22), 11348-11381, 2014 | 168 | 2014 |
| Novel dengue virus NS2B/NS3 protease inhibitors H Wu, S Bock, M Snitko, T Berger, T Weidner, S Holloway, M Kanitz, ... Antimicrobial agents and chemotherapy 59 (2), 1100-1109, 2015 | 163 | 2015 |
| Flavonoids as noncompetitive inhibitors of Dengue virus NS2B-NS3 protease: Inhibition kinetics and docking studies LRF de Sousa, H Wu, L Nebo, JB Fernandes, W Kiefer, M Kanitz, ... Bioorganic & medicinal chemistry 23 (3), 466-470, 2015 | 157 | 2015 |
| Prospective evaluation of free energy calculations for the prioritization of Cathepsin L inhibitors B Kuhn, M Tichý, L Wang, S Robinson, RE Martin, A Kuglstatter, J Benz, ... Journal of medicinal chemistry 60 (6), 2485-2497, 2017 | 144 | 2017 |
| Transcriptome and functional analysis of the eukaryotic-type serine/threonine kinase PknB in Staphylococcus aureus S Donat, K Streker, T Schirmeister, S Rakette, T Stehle, M Liebeke, M Lalk, ... Journal of bacteriology 191 (13), 4056-4069, 2009 | 129 | 2009 |
| Inhibitors of cysteine proteases R Vicik, M Busemann, K Baumann, T Schirmeister Current topics in medicinal chemistry 6 (4), 331-353, 2006 | 121 | 2006 |
| Metabolomics analysis and biological investigation of three Malvaceae plants OH Abdelhafez, EM Othman, JR Fahim, SY Desoukey, ... Phytochemical Analysis 31 (2), 204-214, 2020 | 120 | 2020 |
| The significance of ionic bonding in sulfur dioxide: Bond orders from X‐ray diffraction data S Grabowsky, P Luger, J Buschmann, T Schneider, T Schirmeister, ... Angewandte Chemie International Edition 27 (51), 6776-6779, 2012 | 117 | 2012 |
| Aziridine-2,3-dicarboxylate inhibitors targeting the major cysteine protease of Trypanosoma brucei as lead trypanocidal agents R Vicik, V Hoerr, M Glaser, M Schultheis, E Hansell, JH McKerrow, ... Bioorganic & medicinal chemistry letters 16 (10), 2753-2757, 2006 | 113 | 2006 |
| Antioxidant and anti-protease activities of diazepinomicin from the sponge-associated Micromonospora strain RV115 UR Abdelmohsen, M Szesny, EM Othman, T Schirmeister, S Grond, ... Marine drugs 10 (10), 2208-2221, 2012 | 103 | 2012 |
| Allicin and derivates are cysteine protease inhibitors with antiparasitic activity T Waag, C Gelhaus, J Rath, A Stich, M Leippe, T Schirmeister Bioorganic & medicinal chemistry letters 20 (18), 5541-5543, 2010 | 101 | 2010 |
| Aziridine-2, 3-dicarboxylates, peptidomimetic cysteine protease inhibitors with antileishmanial activity A Ponte-Sucre, R Vicik, M Schultheis, T Schirmeister, H Moll Antimicrobial agents and chemotherapy 50 (7), 2439-2447, 2006 | 94 | 2006 |
| New peptidic cysteine protease inhibitors derived from the electrophilic α-amino acid aziridine-2, 3-dicarboxylic acid T Schirmeister Journal of medicinal chemistry 42 (4), 560-572, 1999 | 94 | 1999 |
| Novel peptidomimetics containing a vinyl ester moiety as highly potent and selective falcipain-2 inhibitors R Ettari, N Micale, T Schirmeister, C Gelhaus, M Leippe, E Nizi, ... Journal of medicinal chemistry 52 (7), 2157-2160, 2009 | 93 | 2009 |
| Quantum chemical-based protocol for the rational design of covalent inhibitors T Schirmeister, J Kesselring, S Jung, TH Schneider, A Weickert, J Becker, ... Journal of the American Chemical Society 138 (27), 8332-8335, 2016 | 90 | 2016 |
| Evidence for substrate binding-induced zwitterion formation in the catalytic Cys-His dyad of the SARS-CoV main protease A Paasche, A Zipper, S Schäfer, J Ziebuhr, T Schirmeister, B Engels Biochemistry 53 (37), 5930-5946, 2014 | 90 | 2014 |
| Proline-based allosteric inhibitors of Zika and Dengue virus NS2B/NS3 proteases B Millies, F von Hammerstein, A Gellert, S Hammerschmidt, F Barthels, ... Journal of medicinal chemistry 62 (24), 11359-11382, 2019 | 84 | 2019 |
| A new lead for nonpeptidic active-site-directed inhibitors of the severe acute respiratory syndrome coronavirus main protease discovered by a combination of screening and … U Kaeppler, N Stiefl, M Schiller, R Vicik, A Breuning, W Schmitz, ... Journal of medicinal chemistry 48 (22), 6832-6842, 2005 | 83 | 2005 |
