| Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease A Douangamath, D Fearon, P Gehrtz, T Krojer, P Lukacik, CD Owen, ... Nature communications 11 (1), 5047, 2020 | 524 | 2020 |
| Discovery of intramolecular trans-sialidases in human gut microbiota suggests novel mechanisms of mucosal adaptation LE Tailford, CD Owen, J Walshaw, EH Crost, J Hardy-Goddard, G Le Gall, ... Nature communications 6 (1), 7624, 2015 | 201 | 2015 |
| Sialidases from gut bacteria: a mini-review N Juge, L Tailford, CD Owen Biochemical Society Transactions 44 (1), 166-175, 2016 | 196 | 2016 |
| Elucidation of a sialic acid metabolism pathway in mucus-foraging Ruminococcus gnavus unravels mechanisms of bacterial adaptation to the gut A Bell, J Brunt, E Crost, L Vaux, R Nepravishta, CD Owen, D Latousakis, ... Nature microbiology 4 (12), 2393-2404, 2019 | 130 | 2019 |
| Unravelling the specificity and mechanism of sialic acid recognition by the gut symbiont Ruminococcus gnavus CD Owen, LE Tailford, S Monaco, T Šuligoj, L Vaux, R Lallement, ... Nature communications 8 (1), 2196, 2017 | 95 | 2017 |
| Discovery of SARS-CoV-2 M pro peptide inhibitors from modelling substrate and ligand binding HTH Chan, MA Moesser, RK Walters, TR Malla, RM Twidale, T John, ... Chemical science 12 (41), 13686-13703, 2021 | 73 | 2021 |
| Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors ML Boby, D Fearon, M Ferla, M Filep, L Koekemoer, MC Robinson, ... Science 382 (6671), eabo7201, 2023 | 72 | 2023 |
| An automatic pipeline for the design of irreversible derivatives identifies a potent SARS-CoV-2 Mpro inhibitor D Zaidman, P Gehrtz, M Filep, D Fearon, R Gabizon, A Douangamath, ... Cell chemical biology 28 (12), 1795-1806. e5, 2021 | 70 | 2021 |
| Fucosidases from the human gut symbiont Ruminococcus gnavus H Wu, O Rebello, EH Crost, CD Owen, S Walpole, C Bennati-Granier, ... Cellular and Molecular Life Sciences 78, 675-693, 2021 | 65 | 2021 |
| Streptococcus pneumoniae NanC: structural insights into the specificity and mechanism of a sialidase that produces a sialidase inhibitor CD Owen, P Lukacik, JA Potter, O Sleator, GL Taylor, MA Walsh Journal of Biological Chemistry 290 (46), 27736-27748, 2015 | 62 | 2015 |
| Alkyne derivatives of SARS-CoV-2 main protease inhibitors including nirmatrelvir inhibit by reacting covalently with the Nucleophilic Cysteine L Brewitz, L Dumjahn, Y Zhao, CD Owen, SM Laidlaw, TR Malla, ... Journal of Medicinal Chemistry 66 (4), 2663-2680, 2023 | 48 | 2023 |
| xia2. multiplex: a multi-crystal data-analysis pipeline RJ Gildea, J Beilsten-Edmands, D Axford, S Horrell, P Aller, J Sandy, ... Acta Crystallographica Section D: Structural Biology 78 (6), 752-769, 2022 | 48 | 2022 |
| Mass spectrometry reveals potential of β-lactams as SARS-CoV-2 M pro inhibitors TR Malla, A Tumber, T John, L Brewitz, C Strain-Damerell, CD Owen, ... Chemical Communications 57 (12), 1430-1433, 2021 | 47 | 2021 |
| Bispecific repurposed medicines targeting the viral and immunological arms of COVID-19 MA Redhead, CD Owen, L Brewitz, AH Collette, P Lukacik, ... Scientific reports 11 (1), 13208, 2021 | 38 | 2021 |
| Biochemical and structural basis of sialic acid utilization by gut microbes A Bell, E Severi, CD Owen, D Latousakis, N Juge Journal of Biological Chemistry 299 (3), 2023 | 34 | 2023 |
| Penicillin derivatives inhibit the SARS-CoV-2 main protease by reaction with its nucleophilic cysteine TR Malla, L Brewitz, DG Muntean, H Aslam, CD Owen, E Salah, A Tumber, ... Journal of medicinal chemistry 65 (11), 7682-7696, 2022 | 32 | 2022 |
| In vitro selection of macrocyclic peptide inhibitors containing cyclic γ2,4-amino acids targeting the SARS-CoV-2 main protease T Miura, TR Malla, CD Owen, A Tumber, L Brewitz, MA McDonough, ... Nature Chemistry 15 (7), 998-1005, 2023 | 31 | 2023 |
| Accelerating drug target inhibitor discovery with a deep generative foundation model V Chenthamarakshan, SC Hoffman, CD Owen, P Lukacik, ... Science Advances 9 (25), eadg7865, 2023 | 25 | 2023 |
| The human gut symbiont Ruminococcus gnavus shows specificity to blood group A antigen during mucin glycan foraging: Implication for niche colonisation in the … H Wu, EH Crost, CD Owen, W Van Bakel, A Martínez Gascueña, ... PLoS Biology 19 (12), e3001498, 2021 | 25 | 2021 |
| Streptococcus oralis subsp. dentisani Produces Monolateral Serine-Rich Repeat Protein Fibrils, One of Which Contributes to Saliva Binding via Sialic Acid A Ronis, K Brockman, AK Singh, MO Gaytán, A Wong, S McGrath, ... Infection and immunity 87 (10), 10.1128/iai. 00406-19, 2019 | 21 | 2019 |
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