| Enhanced preclinical antitumor activity of M7824, a bifunctional fusion protein simultaneously targeting PD-L1 and TGF-β Y Lan, D Zhang, C Xu, KW Hance, B Marelli, J Qi, H Yu, G Qin, A Sircar, ... Science translational medicine 10 (424), eaan5488, 2018 | 476 | 2018 |
| Design, calibration, and performance of the MINERvA detector L Aliaga, L Bagby, B Baldin, A Baumbaugh, A Bodek, R Bradford, ... Nuclear Instruments and Methods in Physics Research Section A: Accelerators …, 2014 | 373 | 2014 |
| Measurement of Muon Antineutrino Quasielastic Scattering <?format ?>on a Hydrocarbon Target at L Fields, J Chvojka, L Aliaga, O Altinok, B Baldin, A Baumbaugh, A Bodek, ... Physical review letters 111 (2), 022501, 2013 | 357* | 2013 |
| Simultaneous targeting of TGF-β/PD-L1 synergizes with radiotherapy by reprogramming the tumor microenvironment to overcome immune evasion Y Lan, M Moustafa, M Knoll, C Xu, J Furkel, A Lazorchak, TL Yeung, ... Cancer cell 39 (10), 1388-1403. e10, 2021 | 138 | 2021 |
| High-throughput sequencing reveals a simple model of nucleosome energetics G Locke, D Tolkunov, Z Moqtaderi, K Struhl, AV Morozov Proceedings of the National Academy of Sciences 107 (49), 20998-21003, 2010 | 82 | 2010 |
| Statistical mechanics of nucleosome ordering by chromatin-structure-induced two-body interactions RV Chereji, D Tolkunov, G Locke, AV Morozov Physical Review E—Statistical, Nonlinear, and Soft Matter Physics 83 (5 …, 2011 | 67 | 2011 |
| Connective Tissue Growth Factor Domain 4 Amplifies Fibrotic Kidney Disease through Activation of LDL Receptor–Related Protein 6 BG Johnson, S Ren, G Karaca, IG Gomez, C Fligny, B Smith, A Ergun, ... Journal of the American Society of Nephrology 28 (6), 1769-1782, 2017 | 38 | 2017 |
| Bintrafusp alfa, a bifunctional fusion protein targeting TGF-β and PD-L1, in patients with non-small cell lung cancer resistant or refractory to immune checkpoint inhibitors F Barlesi, N Isambert, E Felip, BC Cho, DH Lee, J Peguero, G Jerusalem, ... The oncologist 28 (3), 258-267, 2023 | 26 | 2023 |
| Global remodeling of nucleosome positions in C. elegans G Locke, D Haberman, SM Johnson, AV Morozov BMC genomics 14, 1-20, 2013 | 25 | 2013 |
| Colocalized targeting of TGF-β and PD-L1 by bintrafusp alfa elicits distinct antitumor responses Y Lan, TL Yeung, H Huang, AA Wegener, S Saha, M Toister-Achituv, ... Journal for Immunotherapy of Cancer 10 (7), 2022 | 21 | 2022 |
| A biophysical approach to predicting protein–DNA binding energetics G Locke, AV Morozov Genetics 200 (4), 1349-1361, 2015 | 8 | 2015 |
| Identification of HMGA2 as a predictive biomarker of response to bintrafusp alfa in a phase 1 trial in patients with advanced triple-negative breast cancer A Spira, A Awada, N Isambert, D Lorente, N Penel, Y Zhang, LS Ojalvo, ... Frontiers in Oncology 12, 981940, 2022 | 3 | 2022 |
| Simultaneous targeting of TGF-b/PD-L1 synergizes with radiotherapy by reprogramming the tumor microenvironment to overcome immune evasion A Lazorchak, TL Yeung, SM Hasheminasab, MH Jenkins, S Meister, ... Cancer Cell 39, 1-16, 2021 | 3 | 2021 |
| Risk assessment of drug–drug interaction potential for bintrafusp alfa with cytochrome P4503A4 substrates: A totality of evidence approach Y Vugmeyster, G Locke, C Helwig, PA Rolfe, JQ Dong, K Venkatakrishnan Clinical and Translational Science 15 (12), 2838-2843, 2022 | 2 | 2022 |
| Abstract P3-09-13: Identification of a tumor biomarker in advanced triple-negative breast cancer that predicts response to bintrafusp alfa (M7824), a bifunctional fusion … G Locke, Y Zhang, LS Ojalvo, C Helwig, A Rolfe, O Christensen, ... Cancer Research 80 (4_Supplement), P3-09-13-P3-09-13, 2020 | 2 | 2020 |
| RISK ASSESSMENT FOR POTENTIAL DRUG-DRUG INTERACTIONS (DDI) FOR BINTRAFUSP ALFA: A TOTALITY OF EVIDENCE APPROACH INFORMED BY EVALUATION OF CYP3A BIOMARKER MODULATION, CYTOKINE … Y Vugmeyster, G Locke, C Helwig, P Rolfe, J Dong, K Venkatakrishnan CLINICAL PHARMACOLOGY & THERAPEUTICS 111, S55-S55, 2022 | | 2022 |
| Treatment of triple negative breast cancer with targeted tgf-b inhibition G Locke, I Dussault US Patent App. 17/176,427, 2021 | | 2021 |
| Evaluation of immune phenotypes and gene expression profiles in tumors from patients treated with bintrafusp alfa G Locke, C Ihling, C Helwig, LS Ojalvo, O Christensen, I Dussault Cancer Research 80 (16_Supplement), 3290-3290, 2020 | | 2020 |
| Association between TGF-β signaling and HMGA2, a potential biomarker for bintrafusp alfa in triple negative breast cancer TL Yeung, G Locke, A Lazorchak, G Qin, H Yu, J Qi, B Marelli, M Jenkins, ... Cancer Research 80 (16_Supplement), 1573-1573, 2020 | | 2020 |
| Identification of a tumor biomarker in advanced triple-negative breast cancer that predicts response to bintrafusp alfa (M7824), a bifunctional fusion protein targeting … G Locke, Y Zhang, LS Ojalvo, C Helwig, A Rolfe, O Christensen, ... CANCER RESEARCH 80 (4), 2020 | | 2020 |
Alexandre MorozovProfessor of Physics, Rutgers UniversityVerificeret mail på physics.rutgers.edu