| The third international consensus definitions for sepsis and septic shock (Sepsis-3) M Singer, CS Deutschman, CW Seymour, M Shankar-Hari, D Annane, ... Jama 315 (8), 801-810, 2016 | 28216 | 2016 |
| Surviving sepsis campaign: international guidelines for management of sepsis and septic shock: 2016 A Rhodes, LE Evans, W Alhazzani, MM Levy, M Antonelli, R Ferrer, ... Intensive care medicine 43, 304-377, 2017 | 11227 | 2017 |
| Assessment of clinical criteria for sepsis: for the third international consensus definitions for sepsis and septic shock (Sepsis-3) CW Seymour, VX Liu, TJ Iwashyna, FM Brunkhorst, TD Rea, A Scherag, ... Jama 315 (8), 762-774, 2016 | 4578 | 2016 |
| Hydrocortisone therapy for patients with septic shock CL Sprung, D Annane, D Keh, R Moreno, M Singer, K Freivogel, ... New England Journal of Medicine 358 (2), 111-124, 2008 | 2756 | 2008 |
| Developing a new definition and assessing new clinical criteria for septic shock: for the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) M Shankar-Hari, GS Phillips, ML Levy, CW Seymour, VX Liu, ... Jama 315 (8), 775-787, 2016 | 2704* | 2016 |
| Trial of early, goal-directed resuscitation for septic shock PR Mouncey, TM Osborn, GS Power, DA Harrison, MZ Sadique, ... New England Journal of Medicine 372 (14), 1301-1311, 2015 | 1885 | 2015 |
| Association between mitochondrial dysfunction and severity and outcome of septic shock D Brealey, M Brand, I Hargreaves, S Heales, J Land, R Smolenski, ... The Lancet 360 (9328), 219-223, 2002 | 1797 | 2002 |
| Executive summary of the guidelines on the diagnosis and treatment of acute heart failure: the Task Force on Acute Heart Failure of the European Society of Cardiology Endorsed by the European Society of Intensive Care Medicine (ESICM), ... European heart journal 26 (4), 384-416, 2005 | 1649 | 2005 |
| Assessment of the clinical effectiveness of pulmonary artery catheters in management of patients in intensive care (PAC-Man): a randomised controlled trial S Harvey, DA Harrison, M Singer, J Ashcroft, CM Jones, D Elbourne, ... The Lancet 366 (9484), 472-477, 2005 | 1187 | 2005 |
| Recommendations for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients: consensus statements from an international task force by the … PE Marik, SM Pastores, D Annane, GU Meduri, CL Sprung, W Arlt, D Keh, ... Critical care medicine 36 (6), 1937-1949, 2008 | 1163 | 2008 |
| Intraoperative intravascular volume optimisation and length of hospital stay after repair of proximal femoral fracture: randomised controlled trial S Sinclair, S James, M Singer Bmj 315 (7113), 909-912, 1997 | 948 | 1997 |
| Mechanisms of sepsis-induced cardiac dysfunction A Rudiger, M Singer Critical care medicine 35 (6), 1599-1608, 2007 | 879 | 2007 |
| Preliminary UK experience of dexmedetomidine, a novel agent for postoperative sedation in the intensive care unit RM Venn, CJ Bradshaw, R Spencer, D Brealey, E Caudwell, C Naughton, ... Anaesthesia 54 (12), 1136-1142, 1999 | 811 | 1999 |
| Effect of heart rate control with esmolol on hemodynamic and clinical outcomes in patients with septic shock: a randomized clinical trial A Morelli, C Ertmer, M Westphal, S Rehberg, T Kampmeier, S Ligges, ... Jama 310 (16), 1683-1691, 2013 | 801 | 2013 |
| Effect of conservative vs conventional oxygen therapy on mortality among patients in an intensive care unit: the oxygen-ICU randomized clinical trial M Girardis, S Busani, E Damiani, A Donati, L Rinaldi, A Marudi, A Morelli, ... Jama 316 (15), 1583-1589, 2016 | 775 | 2016 |
| Prevalence and outcomes of infection among patients in intensive care units in 2017 JL Vincent, Y Sakr, M Singer, I Martin-Loeches, FR Machado, JC Marshall, ... Jama 323 (15), 1478-1487, 2020 | 768 | 2020 |
| Multiorgan failure is an adaptive, endocrine-mediated, metabolic response to overwhelming systemic inflammation M Singer, V De Santis, D Vitale, W Jeffcoate The Lancet 364 (9433), 545-548, 2004 | 731 | 2004 |
| The role of mitochondrial dysfunction in sepsis-induced multi-organ failure M Singer Virulence 5 (1), 66-72, 2014 | 651 | 2014 |
| Mechanisms of sepsis-induced organ dysfunction E Abraham, M Singer Critical care medicine 35 (10), 2408-2416, 2007 | 642 | 2007 |
| Mitochondrial dysfunction in a long-term rodent model of sepsis and organ failure D Brealey, S Karyampudi, TS Jacques, M Novelli, R Stidwill, V Taylor, ... American Journal of Physiology-Regulatory, Integrative and Comparative …, 2004 | 592 | 2004 |
