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sannula kesavardhana
sannula kesavardhana
Department of Biochemistry, Indian Institute of Science, Bangalore, India.
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Caspases in cell death, inflammation, and pyroptosis
S Kesavardhana, RKS Malireddi, TD Kanneganti
Annual review of immunology 38 (1), 567-595, 2020
7512020
ZBP1/DAI is an innate sensor of influenza virus triggering the NLRP3 inflammasome and programmed cell death pathways
T Kuriakose, SM Man, RK Subbarao Malireddi, R Karki, S Kesavardhana, ...
Science immunology 1 (2), aag2045-aag2045, 2016
6732016
ZBP1 and TAK1: master regulators of NLRP3 inflammasome/pyroptosis, apoptosis, and necroptosis (PAN-optosis)
RKS Malireddi, S Kesavardhana, TD Kanneganti
Frontiers in cellular and infection microbiology 9, 406, 2019
4302019
Identification of the PANoptosome: a molecular platform triggering pyroptosis, apoptosis, and necroptosis (PANoptosis)
S Christgen, M Zheng, S Kesavardhana, R Karki, RKS Malireddi, ...
Frontiers in cellular and infection microbiology 10, 237, 2020
3752020
DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome
P Samir, S Kesavardhana, DM Patmore, S Gingras, RKS Malireddi, ...
Nature 573 (7775), 590-594, 2019
3582019
IRGB10 liberates bacterial ligands for sensing by the AIM2 and caspase-11-NLRP3 inflammasomes
SM Man, R Karki, M Sasai, DE Place, S Kesavardhana, J Temirov, ...
Cell 167 (2), 382-396. e17, 2016
3062016
Innate immune priming in the absence of TAK1 drives RIPK1 kinase activity–independent pyroptosis, apoptosis, necroptosis, and inflammatory disease
RKS Malireddi, P Gurung, S Kesavardhana, P Samir, A Burton, ...
Journal of Experimental Medicine 217 (3), e20191644, 2019
2732019
Mechanisms governing inflammasome activation, assembly and pyroptosis induction
S Kesavardhana, TD Kanneganti
International Immunology 29 (5), 201-210, 2017
2422017
NLRC3 is an inhibitory sensor of PI3K–mTOR pathways in cancer
R Karki, SM Man, RKS Malireddi, S Kesavardhana, Q Zhu, AR Burton, ...
Nature 540 (7634), 583-587, 2016
1912016
ZBP1/DAI ubiquitination and sensing of influenza vRNPs activate programmed cell death
S Kesavardhana, T Kuriakose, CS Guy, P Samir, RK Malireddi, A Mishra, ...
Journal of Experimental Medicine 214 (8), 2217-2229, 2017
1662017
ZBP1 promotes fungi-induced inflammasome activation and pyroptosis, apoptosis, and necroptosis (PANoptosis)
B Banoth, S Tuladhar, R Karki, BR Sharma, B Briard, S Kesavardhana, ...
Journal of Biological Chemistry 295 (52), 18276-18283, 2020
1432020
The Zα2 domain of ZBP1 is a molecular switch regulating influenza-induced PANoptosis and perinatal lethality during development
S Kesavardhana, RKS Malireddi, AR Burton, SN Porter, P Vogel, ...
Journal of Biological Chemistry 295 (24), 8325-8330, 2020
1332020
RIPK1 distinctly regulates yersinia-induced inflammatory cell death, PANoptosis
RK Malireddi, S Kesavardhana, R Karki, B Kancharana, AR Burton, ...
Immunohorizons 4 (12), 789-796, 2020
1242020
Stabilizing the native trimer of HIV-1 Env by destabilizing the heterodimeric interface of the gp41 postfusion six-helix bundle
S Kesavardhana, R Varadarajan
Journal of Virology 88 (17), 9590-9604, 2014
522014
DDX3X coordinates host defense against influenza virus by activating the NLRP3 inflammasome and type I interferon response
S Kesavardhana, P Samir, M Zheng, RKS Malireddi, R Karki, BR Sharma, ...
Journal of Biological Chemistry 296, 2021
462021
Glycosylation of the core of the HIV-1 envelope subunit protein gp120 is not required for native trimer formation or viral infectivity
U Rathore, P Saha, S Kesavardhana, AA Kumar, R Datta, ...
Journal of Biological Chemistry 292 (24), 10197-10219, 2017
392017
Emerging role of ZBP1 in Z-RNA sensing, influenza virus-induced cell death, and pulmonary inflammation
S Basavaraju, S Mishra, R Jindal, S Kesavardhana
MBio 13 (3), e00401-22, 2022
332022
A trimeric HIV-1 envelope gp120 immunogen induces potent and broad anti-V1V2 loop antibodies against HIV-1 in rabbits and rhesus macaques
AT Jones, V Chamcha, S Kesavardhana, X Shen, D Beaumont, R Das, ...
Journal of Virology 92 (5), 10.1128/jvi. 01796-17, 2018
332018
Immunogen design for HIV-1 and influenza
U Rathore, S Kesavardhana, VVA Mallajosyula, R Varadarajan
Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1844 (11), 1891-1906, 2014
312014
ZBP1: A STARGᐰTE to decode the biology of Z-nucleic acids in disease
S Kesavardhana, TD Kanneganti
The Journal of experimental medicine 217 (7), e20200885, 2020
292020
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