Synergistic polymorphism at two positions distal to the ligand-binding site makes KIR2DL2 a stronger receptor for HLA-C than KIR2DL3 AK Moesta, PJ Norman, M Yawata, N Yawata, M Gleimer, P Parham The Journal of Immunology 180 (6), 3969-3979, 2008 | 474 | 2008 |
Targeting CD39 in cancer AK Moesta, XY Li, MJ Smyth Nature Reviews Immunology 20 (12), 739-755, 2020 | 271 | 2020 |
KIR2DS4 is a product of gene conversion with KIR3DL2 that introduced specificity for HLA-A*11 while diminishing avidity for HLA-C T Graef, AK Moesta, PJ Norman, L Abi-Rached, L Vago, AM Older Aguilar, ... Journal of Experimental Medicine 206 (11), 2557-2572, 2009 | 268 | 2009 |
Targeting CD39 in cancer reveals an extracellular ATP-and inflammasome-driven tumor immunity XY Li, AK Moesta, C Xiao, K Nakamura, M Casey, H Zhang, J Madore, ... Cancer discovery 9 (12), 1754-1773, 2019 | 234 | 2019 |
Diverse functionality among human NK cell receptors for the C1 epitope of HLA-C: KIR2DS2, KIR2DL2, and KIR2DL3 AK Moesta, P Parham Frontiers in immunology 3, 336, 2012 | 141 | 2012 |
Co-evolution of KIR2DL3 with HLA-C in a human population retaining minimal essential diversity of KIR and HLA class I ligands K Gendzekhadze, PJ Norman, L Abi-Rached, T Graef, AK Moesta, ... Proceedings of the National Academy of Sciences 106 (44), 18692-18697, 2009 | 137 | 2009 |
Meiotic recombination generates rich diversity in NK cell receptor genes, alleles, and haplotypes PJ Norman, L Abi-Rached, K Gendzekhadze, JA Hammond, AK Moesta, ... Genome research 19 (5), 757-769, 2009 | 127 | 2009 |
Local Delivery of OncoVEXmGM-CSF Generates Systemic Antitumor Immune Responses Enhanced by Cytotoxic T-Lymphocyte–Associated Protein Blockade AK Moesta, K Cooke, J Piasecki, P Mitchell, JB Rottman, K Fitzgerald, ... Clinical Cancer Research 23 (20), 6190-6202, 2017 | 111 | 2017 |
Mutation at positively selected positions in the binding site for HLA-C shows that KIR2DL1 is a more refined but less adaptable NK cell receptor than KIR2DL3 HG Hilton, L Vago, AM Older Aguilar, AK Moesta, T Graef, L Abi-Rached, ... The Journal of Immunology 189 (3), 1418-1430, 2012 | 103 | 2012 |
Humans differ from other hominids in lacking an activating NK cell receptor that recognizes the C1 epitope of MHC class I AK Moesta, T Graef, L Abi-Rached, AM Older Aguilar, LA Guethlein, ... The Journal of Immunology 185 (7), 4233-4237, 2010 | 95 | 2010 |
Human-specific evolution and adaptation led to major qualitative differences in the variable receptors of human and chimpanzee natural killer cells L Abi-Rached, AK Moesta, R Rajalingam, LA Guethlein, P Parham PLoS genetics 6 (11), e1001192, 2010 | 92 | 2010 |
Coevolution of killer cell Ig-like receptors with HLA-C to become the major variable regulators of human NK cells AM Older Aguilar, LA Guethlein, EJ Adams, L Abi-Rached, AK Moesta, ... The Journal of Immunology 185 (7), 4238-4251, 2010 | 91 | 2010 |
Primate‐specific regulation of natural killer cells P Parham, L Abi‐Rached, L Matevosyan, AK Moesta, PJ Norman, ... Journal of Medical Primatology 39 (4), 194-212, 2010 | 87 | 2010 |
Peptide register shifting within the MHC groove: theory becomes reality AJ Bankovich, AT Girvin, AK Moesta, KC Garcia Molecular immunology 40 (14-15), 1033-1039, 2004 | 68 | 2004 |
Control of metastases via myeloid CD39 and NK cell effector function J Yan, XY Li, A Roman Aguilera, C Xiao, C Jacoberger-Foissac, B Nowlan, ... Cancer Immunology Research 8 (3), 356-367, 2020 | 67 | 2020 |
Evolution and survival of marine carnivores did not require a diversity of killer cell Ig-like receptors or Ly49 NK cell receptors JA Hammond, LA Guethlein, L Abi-Rached, AK Moesta, P Parham The Journal of Immunology 182 (6), 3618-3627, 2009 | 62 | 2009 |
Chimpanzees use more varied receptors and ligands than humans for inhibitory killer cell Ig-like receptor recognition of the MHC-C1 and MHC-C2 epitopes AK Moesta, L Abi-Rached, PJ Norman, P Parham The Journal of Immunology 182 (6), 3628-3637, 2009 | 58 | 2009 |
The production of KIR–Fc fusion proteins and their use in a multiplex HLA class I binding assay HG Hilton, AK Moesta, LA Guethlein, J Blokhuis, P Parham, PJ Norman Journal of immunological methods 425, 79-87, 2015 | 24 | 2015 |
T cell receptor β chain gene usage in endemic pemphigus foliaceus (Fogo Selvagem) AK Moesta, AA Sinha, MS Lin, LA Diaz Journal of investigative dermatology 119 (2), 377-383, 2002 | 10 | 2002 |
targeting CD39 with a first-in-class inhibitory antibody prevents ATP processing and increases T-cell activation AG Lerner, M Kovalenko, M Welch, T Cruz, J Jones, C Wong, B Spatola, ... Cancer Research 79 (13_Supplement), 5012-5012, 2019 | 7 | 2019 |