Luhua Lai

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Jianfeng PeiPeking UniversityVerificeret mail på pku.edu.cn
Renxiao WangFudan UniversityVerificeret mail på fudan.edu.cn
Ping “Andy” Wei - 魏平Shenzhen Institute of Advanced TechnologyVerificeret mail på siat.ac.cn
Chao TangProfessor of Physics, Peking UniversityVerificeret mail på pku.edu.cn
Ziwei DaiAssistant Professor, Southern University of Science and TechnologyVerificeret mail på sustech.edu.cn
Yaxia YuanUniversity of Texas Health Science Center at San AntonioVerificeret mail på uthscsa.edu
Xiaobing DengPeking UinversityVerificeret mail på pku.edu.cn
Kun YangJohns Hopkins School of MedicineVerificeret mail på jhu.edu
Hu MengUniversity of PennsylvaniaVerificeret mail på pennmedicine.upenn.edu
Shuaishi (Sophia) GaoPh.D. student at Center for Quantitative Biology, Peking UniversityVerificeret mail på pku.edu.cn
ZHIJIE LIUJanssen Research & Development, Allergan LLC, Vitae Pharmaceuticals, University of Georgia, Harvard University, Peking UniversityVerificeret mail på its.jnj.com
Shiyong LiuAssociate Professor, Department of Physics, Huazhong University of Science and TechnologyVerificeret mail på mail.hust.edu.cn
Chong HePostdoctoral Research Fellow at Buck Institute for Research on AgingVerificeret mail på buckinstitute.org
Yifei QiFudan UniversityVerificeret mail på fudan.edu.cn
Weizhong LiJ Craig Venter InstituteVerificeret mail på sdsc.edu
Lin JiangAssociate Professor of Neurology, University of California, Los AngelesVerificeret mail på ucla.edu
Hongjun BaiMHRP|HJFVerificeret mail på hivresearch.org
Li-Jia QuPeking UniversityVerificeret mail på pku.edu.cn
Xiaofeng HanWayne State UniversityVerificeret mail på med.wayne.edu
Qingliang LiNational institutes of healthVerificeret mail på ncbi.nlm.nih.gov

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Luhua Lai

Professor of Chemistry, Peking University

Verificeret mail på pku.edu.cn - Startside

biophysical chemistry computational chemical biology protein design drug design


Titel Sortér efter henvisninger Sortér efter årstal Sortér efter titel	Citeret af Citeret af	År
Further development and validation of empirical scoring functions for structure-based binding affinity prediction R Wang, L Lai, S Wang Journal of computer-aided molecular design 16, 11-26, 2002	1527	2002
PharmMapper 2017 update: a web server for potential drug target identification with a comprehensive target pharmacophore database X Wang, Y Shen, S Wang, S Li, W Zhang, X Liu, L Lai, J Pei, H Li Nucleic acids research 45 (W1), W356-W360, 2017	1128	2017
Computation of octanol− water partition coefficients by guiding an additive model with knowledge T Cheng, Y Zhao, X Li, F Lin, Y Xu, X Zhang, Y Li, R Wang, L Lai Journal of chemical information and modeling 47 (6), 2140-2148, 2007	891	2007
A new atom-additive method for calculating partition coefficients R Wang, Y Fu, L Lai Journal of chemical information and computer sciences 37 (3), 615-621, 1997	576	1997
LigBuilder: a multi-purpose program for structure-based drug design R Wang, Y Gao, L Lai Molecular modeling annual 6, 498-516, 2000	430	2000
Sequence-based prediction of protein protein interaction using a deep-learning algorithm T Sun, B Zhou, L Lai, J Pei BMC bioinformatics 18, 1-8, 2017	418	2017
SCORE: A new empirical method for estimating the binding affinity of a protein-ligand complex R Wang, L Liu, L Lai, Y Tang Molecular modeling annual 4, 379-394, 1998	412	1998
Arabidopsis pollen tube integrity and sperm release are regulated by RALF-mediated signaling Z Ge, T Bergonci, Y Zhao, Y Zou, S Du, MC Liu, X Luo, H Ruan, ... Science 358 (6370), 1596-1600, 2017	400	2017
Biosynthesis, purification, and substrate specificity of severe acute respiratory syndrome coronavirus 3C-like proteinase K Fan, P Wei, Q Feng, S Chen, C Huang, L Ma, B Lai, J Pei, Y Liu, J Chen, ... Journal of Biological Chemistry 279 (3), 1637-1642, 2004	391	2004
Deep learning for drug-induced liver injury Y Xu, Z Dai, F Chen, S Gao, J Pei, L Lai Journal of chemical information and modeling 55 (10), 2085-2093, 2015	381	2015
Synthesis, fungicidal activity, and 3D-QSAR of pyridazinone-substituted 1, 3, 4-oxadiazoles and 1, 3, 4-thiadiazoles XJ Zou, LH Lai, GY Jin, ZX Zhang Journal of agricultural and food chemistry 50 (13), 3757-3760, 2002	376	2002
Scutellaria baicalensis extract and baicalein inhibit replication of SARS-CoV-2 and its 3C-like protease in vitro H Liu, F Ye, Q Sun, H Liang, C Li, S Li, R Lu, B Huang, W Tan, L Lai Journal of enzyme inhibition and medicinal chemistry 36 (1), 497-503, 2021	337	2021
A protein engineered to bind uranyl selectively and with femtomolar affinity L Zhou, M Bosscher, C Zhang, S Özçubukçu, L Zhang, W Zhang, CJ Li, ... Nature chemistry 6 (3), 236-241, 2014	321	2014
Transfer learning for drug discovery C Cai, S Wang, Y Xu, W Zhang, K Tang, Q Ouyang, L Lai, J Pei Journal of Medicinal Chemistry 63 (16), 8683-8694, 2020	305	2020
CavityPlus: a web server for protein cavity detection with pharmacophore modelling, allosteric site identification and covalent ligand binding ability prediction Y Xu, S Wang, Q Hu, S Gao, X Ma, W Zhang, Y Shen, F Chen, L Lai, J Pei Nucleic acids research 46 (W1), W374-W379, 2018	302	2018
CH··· O Hydrogen Bonds at Protein-Protein Interfaces* 210 L Jiang, L Lai Journal of Biological Chemistry 277 (40), 37732-37740, 2002	277	2002
Calculating partition coefficient by atom-additive method R Wang, Y Gao, L Lai Perspectives in Drug Discovery and Design 19, 47-66, 2000	274	2000
Deep learning based regression and multiclass models for acute oral toxicity prediction with automatic chemical feature extraction Y Xu, J Pei, L Lai Journal of chemical information and modeling 57 (11), 2672-2685, 2017	249	2017
3C-like proteinase from SARS coronavirus catalyzes substrate hydrolysis by a general base mechanism C Huang, P Wei, K Fan, Y Liu, L Lai Biochemistry 43 (15), 4568-4574, 2004	239	2004
LigBuilder 2: A Practical de Novo Drug Design Approach Y Yuan, J Pei, L Lai Journal of chemical information and modeling 51 (5), 1083-1091, 2011	227	2011

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