| Preclinical development of an oral anti-Wolbachia macrolide drug for the treatment of lymphatic filariasis and onchocerciasis MJ Taylor, TW von Geldern, L Ford, MP Hübner, K Marsh, KL Johnston, ... Science translational medicine 11 (483), eaau2086, 2019 | 80 | 2019 |
| AWZ1066S, a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis WD Hong, F Benayoud, GL Nixon, L Ford, KL Johnston, RH Clare, ... Proceedings of the National Academy of Sciences 116 (4), 1414-1419, 2019 | 72 | 2019 |
| Microfilariae trigger eosinophil extracellular DNA traps in a dectin-1-dependent manner A Ehrens, B Lenz, AL Neumann, S Giarrizzo, JJ Reichwald, ... Cell reports 34 (2), 2021 | 47 | 2021 |
| Boron-Pleuromutilins as Anti-Wolbachia Agents with Potential for Treatment of Onchocerciasis and Lymphatic Filariasis RT Jacobs, CS Lunde, YR Freund, V Hernandez, X Li, Y Xia, DS Carter, ... Journal of medicinal chemistry 62 (5), 2521-2540, 2019 | 44 | 2019 |
| Discovery of short-course antiwolbachial quinazolines for elimination of filarial worm infections MA Bakowski, RK Shiroodi, R Liu, J Olejniczak, B Yang, K Gagaring, ... Science translational medicine 11 (491), eaav3523, 2019 | 43 | 2019 |
| Discovery of ABBV-4083, a novel analog of Tylosin A that has potent anti-Wolbachia and anti-filarial activity TW von Geldern, HE Morton, RF Clark, BS Brown, KL Johnston, L Ford, ... PLoS Neglected Tropical Diseases 13 (2), e0007159, 2019 | 40 | 2019 |
| Corallopyronin A for short-course anti-wolbachial, macrofilaricidal treatment of filarial infections A Schiefer, MP Hübner, A Krome, C Lämmer, A Ehrens, T Aden, ... PLoS neglected tropical diseases 14 (12), e0008930, 2020 | 37 | 2020 |
| Susceptibility to L. sigmodontis infection is highest in animals lacking IL-4R/IL-5 compared to single knockouts of IL-4R, IL-5 or eosinophils SJ Frohberger, J Ajendra, J Surendar, W Stamminger, A Ehrens, ... Parasites & vectors 12, 1-16, 2019 | 37 | 2019 |
| In vivo kinetics of Wolbachia depletion by ABBV-4083 in L. sigmodontis adult worms and microfilariae MP Hübner, M Koschel, D Struever, V Nikolov, SJ Frohberger, A Ehrens, ... PLoS neglected tropical diseases 13 (8), e0007636, 2019 | 35 | 2019 |
| Oxfendazole mediates macrofilaricidal efficacy against the filarial nematode Litomosoides sigmodontis in vivo and inhibits Onchocerca spec. motility in vitro MP Hübner, C Martin, S Specht, M Koschel, B Dubben, SJ Frohberger, ... PLoS Neglected Tropical Diseases 14 (7), e0008427, 2020 | 33 | 2020 |
| Macrofilaricidal efficacy of single and repeated oral and subcutaneous doses of flubendazole in Litomosoides sigmodontis infected jirds MP Hübner, A Ehrens, M Koschel, B Dubben, F Lenz, SJ Frohberger, ... PLoS Neglected Tropical Diseases 13 (1), e0006320, 2019 | 28 | 2019 |
| Eosinophils and Neutrophils Eliminate Migrating Strongyloides ratti Larvae at the Site of Infection in the Context of Extracellular DNA Trap Formation A Ehrens, N Rüdiger, L Heepmann, L Linnemann, W Hartmann, ... Frontiers in Immunology 12, 715766, 2021 | 26 | 2021 |
| Current perspective of new anti-Wolbachial and direct-acting macrofilaricidal drugs as treatment strategies for human filariasis A Ehrens, A Hoerauf, MP Hübner GMS Infectious Diseases 10, Doc02, 2022 | 24 | 2022 |
| Eosinophils in filarial infections: Inducers of protection or pathology? A Ehrens, A Hoerauf, MP Hübner Frontiers in Immunology 13, 983812, 2022 | 22 | 2022 |
| Corallopyronin A: antimicrobial discovery to preclinical development AK Krome, T Becker, S Kehraus, A Schiefer, M Gütschow, ... Natural product reports 39 (9), 1705-1720, 2022 | 22 | 2022 |
| Apparent activation energies of protein–protein complex dissociation in the gas–phase determined by electrospray mass spectrometry Y Yefremova, FTI Melder, BD Danquah, KFM Opuni, C Koy, A Ehrens, ... Analytical and Bioanalytical Chemistry 409, 6549-6558, 2017 | 21 | 2017 |
| S100A8/S100A9 deficiency increases neutrophil activation and protective immune responses against invading infective L3 larvae of the filarial nematode Litomosoides sigmodontis SJ Frohberger, F Fercoq, AL Neumann, J Surendar, W Stamminger, ... PLoS neglected tropical diseases 14 (2), e0008119, 2020 | 19 | 2020 |
| Pharmacokinetics and Pharmacodynamics (PK/PD) of Corallopyronin A against Methicillin-Resistant Staphylococcus aureus K Rox, T Becker, A Schiefer, M Grosse, A Ehrens, R Jansen, T Aden, ... Pharmaceutics 15 (1), 131, 2022 | 15 | 2022 |
| In vivo efficacy of the boron-pleuromutilin AN11251 against Wolbachia of the rodent filarial nematode Litomosoides sigmodontis A Ehrens, CS Lunde, RT Jacobs, D Struever, M Koschel, SJ Frohberger, ... PLoS Neglected Tropical Diseases 14 (1), e0007957, 2020 | 14 | 2020 |
| Short-course quinazoline drug treatments are effective in the Litomosoides sigmodontis and Brugia pahangi jird models MP Hübner, E Gunderson, I Vogel, CA Bulman, KC Lim, M Koschel, ... International Journal for Parasitology: Drugs and Drug Resistance 12, 18-27, 2020 | 13 | 2020 |
Marc P HübnerInstitute for Medical Microbiology, Immunology and Parasitology. University Hospital BonnVerificeret mail på uni-bonn.de