| A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression KC Wang, YW Yang, B Liu, A Sanyal, R Corces-Zimmerman, Y Chen, ... Nature 472 (7341), 120-124, 2011 | 2213 | 2011 |
| Crystal structure of human histone lysine-specific demethylase 1 (LSD1) Y Chen, Y Yang, F Wang, K Wan, K Yamane, Y Zhang, M Lei Proceedings of the National Academy of Sciences 103 (38), 13956-13961, 2006 | 376 | 2006 |
| Targeting MLL1 H3K4 methyltransferase activity in mixed-lineage leukemia F Cao, EC Townsend, H Karatas, J Xu, L Li, S Lee, L Liu, Y Chen, ... Molecular cell 53 (2), 247-261, 2014 | 346 | 2014 |
| A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins Y Chen, Y Yang, M Van Overbeek, JR Donigian, P Baciu, T de Lange, ... Science 319 (5866), 1092-1096, 2008 | 334 | 2008 |
| Structural basis for activity regulation of MLL family methyltransferases Y Li, J Han, Y Zhang, F Cao, Z Liu, S Li, J Wu, C Hu, Y Wang, J Shuai, ... Nature 530 (7591), 447-452, 2016 | 248 | 2016 |
| Essential role of lncRNA binding for WDR5 maintenance of active chromatin and embryonic stem cell pluripotency YW Yang, RA Flynn, Y Chen, K Qu, B Wan, KC Wang, M Lei, HY Chang elife 3, e02046, 2014 | 233 | 2014 |
| High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein–protein interaction H Karatas, EC Townsend, F Cao, Y Chen, D Bernard, L Liu, M Lei, Y Dou, ... Journal of the American Chemical Society 135 (2), 669-682, 2013 | 206 | 2013 |
| Developmental ROS individualizes organismal stress resistance and lifespan D Bazopoulou, D Knoefler, Y Zheng, K Ulrich, BJ Oleson, L Xie, M Kim, ... Nature 576 (7786), 301-305, 2019 | 203 | 2019 |
| Activation of DegP chaperone-protease via formation of large cage-like oligomers upon binding to substrate proteins J Jiang, X Zhang, Y Chen, Y Wu, ZH Zhou, Z Chang, SF Sui Proceedings of the National Academy of Sciences 105 (33), 11939, 2008 | 181 | 2008 |
| A conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organisms Y Chen, R Rai, ZR Zhou, J Kanoh, C Ribeyre, Y Yang, H Zheng, P Damay, ... Nature structural & molecular biology 18 (2), 213-221, 2011 | 175 | 2011 |
| Structural basis of nucleosome recognition and modification by MLL methyltransferases H Xue, T Yao, M Cao, G Zhu, Y Li, G Yuan, Y Chen, M Lei, J Huang Nature 573 (7774), 445-449, 2019 | 171 | 2019 |
| TRF2-RAP1 is required to protect telomeres from engaging in homologous recombination-mediated deletions and fusions R Rai, Y Chen, M Lei, S Chang Nature communications 7 (1), 10881, 2016 | 167 | 2016 |
| Structural basis of ligand recognition and self-activation of orphan GPR52 X Lin, M Li, N Wang, Y Wu, Z Luo, S Guo, GW Han, S Li, Y Yue, X Wei, ... Nature 579 (7797), 152-157, 2020 | 138 | 2020 |
| An Ash2L/RbBP5 heterodimer stimulates the MLL1 methyltransferase activity through coordinated substrate interactions with the MLL1 SET domain F Cao, Y Chen, T Cierpicki, Y Liu, V Basrur, M Lei, Y Dou PloS one 5 (11), e14102, 2010 | 138 | 2010 |
| SLX4 assembles a telomere maintenance toolkit by bridging multiple endonucleases with telomeres B Wan, J Yin, K Horvath, J Sarkar, Y Chen, J Wu, K Wan, J Lu, P Gu, ... Cell reports 4 (5), 861-869, 2013 | 132 | 2013 |
| DnaK and DnaJ facilitated the folding process and reduced inclusion body formation of magnesium transporter CorA overexpressed in Escherichia coli Y Chen, J Song, S Sui, DN Wang Protein expression and purification 32 (2), 221-231, 2003 | 121 | 2003 |
| Practical aspects of overexpressing bacterial secondary membrane transporters for structural studies DN Wang, M Safferling, MJ Lemieux, H Griffith, Y Chen, XD Li Biochimica et Biophysica Acta (BBA)-Biomembranes 1610 (1), 23-36, 2003 | 111 | 2003 |
| Structural and functional analyses of the mammalian TIN2-TPP1-TRF2 telomeric complex C Hu, R Rai, C Huang, C Broton, J Long, Y Xu, J Xue, M Lei, S Chang, ... Cell research 27 (12), 1485-1502, 2017 | 107 | 2017 |
| Ring-like pore structures of SecA: Implication for bacterial protein-conducting channels HW Wang, Y Chen, H Yang, X Chen, MX Duan, PC Tai, SF Sui Proceedings of the National Academy of Sciences 100 (7), 4221, 2003 | 99 | 2003 |
| Discovery of a highly potent, cell-permeable macrocyclic peptidomimetic (MM-589) targeting the WD repeat domain 5 protein (WDR5)–mixed lineage leukemia (MLL) protein–protein … H Karatas, Y Li, L Liu, J Ji, S Lee, Y Chen, J Yang, L Huang, D Bernard, ... Journal of medicinal chemistry 60 (12), 4818-4839, 2017 | 97 | 2017 |
Howard Y. ChangChief Scientific Officer, AmgenVerificeret mail på stanford.edu
