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Benjamin Phillips
Benjamin Phillips
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Verificeret mail på astrazeneca.com
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TDP-43 gains function due to perturbed autoregulation in a Tardbp knock-in mouse model of ALS-FTD
MA White, E Kim, A Duffy, R Adalbert, BU Phillips, OM Peters, ...
Nature neuroscience 21 (4), 552-563, 2018
2602018
Basal forebrain and brainstem cholinergic neurons differentially impact amygdala circuits and learning-related behavior
T Aitta-Aho, YA Hay, BU Phillips, LM Saksida, TJ Bussey, O Paulsen, ...
Current Biology 28 (16), 2557-2569. e4, 2018
792018
Measuring motivation and reward‐related decision making in the rodent operant touchscreen system
CJ Heath, BU Phillips, TJ Bussey, LM Saksida
Current protocols in neuroscience 74 (1), 8.34. 1-8.34. 20, 2016
502016
Dopamine D2-like receptor stimulation blocks negative feedback in visual and spatial reversal learning in the rat: behavioural and computational evidence
J Alsiö, BU Phillips, J Sala-Bayo, SRO Nilsson, TC Calafat-Pla, ...
Psychopharmacology 236, 2307-2323, 2019
422019
Optimisation of cognitive performance in rodent operant (touchscreen) testing: evaluation and effects of reinforcer strength
BU Phillips, CJ Heath, Z Ossowska, TJ Bussey, LM Saksida
Learning & Behavior 45, 252-262, 2017
382017
A touchscreen motivation assessment evaluated in Huntington's disease patients and R6/1 model mice
CJ Heath, C O'Callaghan, SL Mason, BU Phillips, LM Saksida, ...
Frontiers in Neurology 10, 858, 2019
362019
Selective effects of 5-HT2C receptor modulation on performance of a novel valence-probe visual discrimination task and probabilistic reversal learning in mice
BU Phillips, S Dewan, SRO Nilsson, TW Robbins, CJ Heath, LM Saksida, ...
Psychopharmacology 235, 2101-2111, 2018
362018
Optimizing reproducibility of operant testing through reinforcer standardization: identification of key nutritional constituents determining reward strength in touchscreens
EW Kim, BU Phillips, CJ Heath, SY Cho, H Kim, J Sreedharan, HT Song, ...
Molecular brain 10, 1-10, 2017
332017
Accumbal cholinergic interneurons differentially influence motivation related to satiety signaling
T Aitta-Aho, BU Phillips, E Pappa, YA Hay, F Harnischfeger, CJ Heath, ...
Eneuro 4 (2), 2017
282017
Assessment of mGluR5 KO mice under conditions of low stress using a rodent touchscreen apparatus reveals impaired behavioural flexibility driven by perseverative responses
J Lim, E Kim, HJ Noh, S Kang, BU Phillips, DG Kim, TJ Bussey, L Saksida, ...
Molecular brain 12, 1-13, 2019
272019
Blockade of muscarinic acetylcholine receptors facilitates motivated behaviour and rescues a model of antipsychotic-induced amotivation
JM Hailwood, CJ Heath, BU Phillips, TW Robbins, LM Saksida, TJ Bussey
Neuropsychopharmacology 44 (6), 1068-1075, 2019
212019
Relaxin/insulin-like family peptide receptor 4 (Rxfp4) expressing hypothalamic neurons modulate food intake and preference in mice
JE Lewis, ORM Woodward, D Nuzzaci, CA Smith, AE Adriaenssens, ...
Molecular metabolism 66, 101604, 2022
182022
Translational approaches to evaluating motivation in laboratory rodents: conventional and touchscreen-based procedures
BU Phillips, L Lopez-Cruz, J Hailwood, CJ Heath, LM Saksida, TJ Bussey
Current Opinion in Behavioral Sciences 22, 21-27, 2018
172018
Reconsidering repurposing: long-term metformin treatment impairs cognition in Alzheimer’s model mice
SY Cho, EW Kim, SJ Park, BU Phillips, J Jeong, H Kim, CJ Heath, D Kim, ...
Translational psychiatry 14 (1), 34, 2024
152024
Statistical simulations show that scientists need not increase overall sample size by default when including both sexes in in vivo studies
B Phillips, TN Haschler, NA Karp
PLoS Biology 21 (6), e3002129, 2023
132023
Retrospective analysis of the potential use of virtual control groups in preclinical toxicity assessment using the eTOX database
PSR Wright, GF Smith, KA Briggs, R Thomas, G Maglennon, P Mikulskis, ...
Regulatory Toxicology and Pharmacology 138, 105309, 2023
132023
The ATR inhibitor ceralasertib potentiates cancer checkpoint immunotherapy by regulating the tumor microenvironment
EL Hardaker, E Sanseviero, A Karmokar, D Taylor, M Milo, C Michaloglou, ...
Nature Communications 15 (1), 1700, 2024
122024
Comparable roles for serotonin in rats and humans for computations underlying flexible decision-making
Q Luo, JW Kanen, A Bari, N Skandali, C Langley, GM Knudsen, J Alsiö, ...
Neuropsychopharmacology 49 (3), 600-608, 2024
122024
Coexistence of perseveration and apathy in the TDP-43Q331K knock-in mouse model of ALS–FTD
E Kim, MA White, BU Phillips, L Lopez-Cruz, H Kim, CJ Heath, JE Lee, ...
Translational psychiatry 10 (1), 377, 2020
122020
Translational tests involving non-reward: methodological considerations
BU Phillips, L Lopez-Cruz, LM Saksida, TJ Bussey
Psychopharmacology 236 (1), 449-461, 2019
122019
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