Lewis Cantley

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John AsaraAssociate Professor Medicine, Harvard Medical School; Director, Beth Israel Deaconess Medical CenterVerificeret mail på bidmc.harvard.edu
Costas LyssiotisProfessor of Physiology, University of MichiganVerificeret mail på lyssiotis.com
Ji LuoNational Cancer InstituteVerificeret mail på nih.gov
David FrumanProfessor of Molecular Biology & Biochemistry, UC IrvineVerificeret mail på uci.edu
John BlenisProfessor of Pharmacology, Weill Cornell MedicineVerificeret mail på med.cornell.edu
Alex TokerVerificeret mail på bidmc.harvard.edu
Jason LocasaleDuke UniversityVerificeret mail på alum.mit.edu
Brendan D. ManningHarvard UniversityVerificeret mail på hsph.harvard.edu
Lucia Rameh PlantVanderbilt UniversityVerificeret mail på vanderbilt.edu
C. Ronald KahnJoslin Diabetes Center and Harvard Medical SchoolVerificeret mail på joslin.harvard.edu
Reuben ShawThe Salk Institute of Biological StudiesVerificeret mail på salk.edu
Pier Paolo PandolfiDirector, Cancer Center and Cancer Research Institute, Beth Israel Deaconess Medical CenterVerificeret mail på bidmc.harvard.edu
Ronald A. DePinhoMD AndersonVerificeret mail på mdanderson.org
David R. KaplanHospital for Sick ChildrenVerificeret mail på sickkids.ca
Steven ShoelsonHarvard Medical SchoolVerificeret mail på joslin.harvard.edu
Gerburg WulfAssociate Professor in Medicine, Harvard Medical SchoolVerificeret mail på bidmc.harvard.edu
Kurt AugerGSKVerificeret mail på gsk.com
Pasi JanneDana Farber Cancer InstituteVerificeret mail på dfci.harvard.edu
Marcus D GoncalvesWeill Cornell New York Presbyterian HospitalVerificeret mail på med.cornell.edu
Malcolm WhitmanHarvardVerificeret mail på hms.harvard.edu

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Lewis Cantley

Dana Farber Cancer Center and Harvard Medical School

Verificeret mail på med.cornell.edu

cancer metabolism signal transduction PI 3-Kinase Protein kinases


Titel Sortér efter henvisninger Sortér efter årstal Sortér efter titel	Citeret af Citeret af	År
Understanding the Warburg effect: the metabolic requirements of cell proliferation MG Vander Heiden, LC Cantley, CB Thompson science 324 (5930), 1029-1033, 2009	17535	2009
AKT/PKB signaling: navigating downstream BD Manning, LC Cantley Cell 129 (7), 1261-1274, 2007	7573	2007
The phosphoinositide 3-kinase pathway LC Cantley Science 296 (5573), 1655-1657, 2002	7448	2002
MET Amplification Leads to Gefitinib Resistance in Lung Cancer by Activating ERBB3 Signaling JA Engelman, K Zejnullahu, T Mitsudomi, Y Song, C Hyland, JO Park, ... science 316 (5827), 1039-1043, 2007	5558	2007
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate L Dang, DW White, S Gross, BD Bennett, MA Bittinger, EM Driggers, ... Nature 462 (7274), 739-744, 2009	4865	2009
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism JA Engelman, J Luo, LC Cantley Nature Reviews Genetics 7 (8), 606-619, 2006	4084	2006
Oncogenes and signal transduction LC Cantley, KR Auger, C Carpenter, B Duckworth, A Graziani, R Kapeller, ... Cell 64 (2), 281-302, 1991	3598	1991
SH2 domains recognize specific phosphopeptide sequences S Zhou, SE Shoelson, M Chaudhuri, G Gish, T Pawson, WG Haser, F King, ... Cell 72 (5), 767-778, 1993	3591	1993
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth HR Christofk, MG Vander Heiden, MH Harris, A Ramanathan, ... Nature 452 (7184), 230-233, 2008	3282	2008
Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis GM DeNicola, FA Karreth, TJ Humpton, A Gopinathan, C Wei, K Frese, ... Nature 475 (7354), 106-109, 2011	2948*	2011
New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway LC Cantley, BG Neel Proceedings of the National Academy of Sciences 96 (8), 4240-4245, 1999	2774	1999
Ras, PI (3) K and mTOR signalling controls tumour cell growth RJ Shaw, LC Cantley Nature 441 (7092), 424-430, 2006	2672	2006
The PI3K pathway in human disease DA Fruman, H Chiu, BD Hopkins, S Bagrodia, LC Cantley, RT Abraham Cell 170 (4), 605-635, 2017	2459	2017
PI3K pathway alterations in cancer: variations on a theme TL Yuan, LC Cantley Oncogene 27 (41), 5497-5510, 2008	2448	2008
The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin RJ Shaw, KA Lamia, D Vasquez, SH Koo, N Bardeesy, RA DePinho, ... Science 310 (5754), 1642-1646, 2005	2422	2005
PI3K: downstream AKTion blocks apoptosis TF Franke, DR Kaplan, LC Cantley Cell 88 (4), 435-437, 1997	2215	1997
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress RJ Shaw, M Kosmatka, N Bardeesy, RL Hurley, LA Witters, RA DePinho, ... Proceedings of the National Academy of Sciences 101 (10), 3329-3335, 2004	2190	2004
Phosphoinositide kinases DA Fruman, RE Meyers, LC Cantley Annual review of biochemistry 67 (1), 481-507, 1998	2154	1998
Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism H Ying, AC Kimmelman, CA Lyssiotis, S Hua, GC Chu, ... Cell 149 (3), 656-670, 2012	2139	2012
Bidirectional transport of amino acids regulates mTOR and autophagy P Nicklin, P Bergman, B Zhang, E Triantafellow, H Wang, B Nyfeler, ... Cell 136 (3), 521-534, 2009	2045	2009

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