| Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease A Douangamath, D Fearon, P Gehrtz, T Krojer, P Lukacik, CD Owen, ... Nature communications 11 (1), 5047, 2020 | 512 | 2020 |
| Structural insight into the biogenesis of β-barrel membrane proteins N Noinaj, AJ Kuszak, JC Gumbart, P Lukacik, H Chang, NC Easley, ... Nature 501 (7467), 385-390, 2013 | 489 | 2013 |
| Structure and function of human 17β-hydroxysteroid dehydrogenases P Lukacik, KL Kavanagh, U Oppermann Molecular and cellular endocrinology 248 (1-2), 61-71, 2006 | 242 | 2006 |
| SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids J Jansen, KC Reimer, JS Nagai, FS Varghese, GJ Overheul, M de Beer, ... Cell stem cell 29 (2), 217-231. e8, 2022 | 215 | 2022 |
| Autotransporter structure reveals intra-barrel cleavage followed by conformational changes TJ Barnard, N Dautin, P Lukacik, HD Bernstein, SK Buchanan Nature structural & molecular biology 14 (12), 1214-1220, 2007 | 204 | 2007 |
| Structural engineering of a phage lysin that targets Gram-negative pathogens P Lukacik, TJ Barnard, PW Keller, KS Chaturvedi, N Seddiki, JW Fairman, ... Proceedings of the National Academy of Sciences 109 (25), 9857-9862, 2012 | 181 | 2012 |
| Complement regulation at the molecular level: the structure of decay-accelerating factor P Lukacik, P Roversi, J White, D Esser, GP Smith, J Billington, ... Proceedings of the National Academy of Sciences 101 (5), 1279-1284, 2004 | 156 | 2004 |
| Structure of colicin I receptor bound to the R‐domain of colicin Ia: implications for protein import SK Buchanan, P Lukacik, S Grizot, R Ghirlando, MMU Ali, TJ Barnard, ... The EMBO journal 26 (10), 2594-2604, 2007 | 133 | 2007 |
| Structural insights into Ail-mediated adhesion in Yersinia pestis S Yamashita, P Lukacik, TJ Barnard, N Noinaj, S Felek, TM Tsang, ... Structure 19 (11), 1672-1682, 2011 | 112 | 2011 |
| Structural and biochemical characterization of human orphan DHRS10 reveals a novel cytosolic enzyme with steroid dehydrogenase activity P Lukacik, B Keller, G Bunkoczi, K Kavanagh, W Hwa Lee, J Adamski, ... Biochemical Journal 402 (3), 419-427, 2007 | 111 | 2007 |
| Characterization of human DHRS6, an orphan short chain dehydrogenase/reductase enzyme: a novel, cytosolic type 2 R-β-hydroxybutyrate dehydrogenase K Guo, P Lukacik, E Papagrigoriou, M Meier, WH Lee, J Adamski, ... Journal of biological chemistry 281 (15), 10291-10297, 2006 | 91 | 2006 |
| SDR-type human hydroxysteroid dehydrogenases involved in steroid hormone activation X Wu, P Lukacik, KL Kavanagh, U Oppermann Molecular and cellular endocrinology 265, 71-76, 2007 | 75 | 2007 |
| Discovery of SARS-CoV-2 M pro peptide inhibitors from modelling substrate and ligand binding HTH Chan, MA Moesser, RK Walters, TR Malla, RM Twidale, T John, ... Chemical science 12 (41), 13686-13703, 2021 | 73 | 2021 |
| Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors ML Boby, D Fearon, M Ferla, M Filep, L Koekemoer, MC Robinson, ... Science 382 (6671), eabo7201, 2023 | 72 | 2023 |
| An automatic pipeline for the design of irreversible derivatives identifies a potent SARS-CoV-2 Mpro inhibitor D Zaidman, P Gehrtz, M Filep, D Fearon, R Gabizon, A Douangamath, ... Cell chemical biology 28 (12), 1795-1806. e5, 2021 | 70 | 2021 |
| Streptococcus pneumoniae NanC: structural insights into the specificity and mechanism of a sialidase that produces a sialidase inhibitor CD Owen, P Lukacik, JA Potter, O Sleator, GL Taylor, MA Walsh Journal of Biological Chemistry 290 (46), 27736-27748, 2015 | 62 | 2015 |
| Interdomain conformational flexibility underpins the activity of UGGT, the eukaryotic glycoprotein secretion checkpoint P Roversi, L Marti, AT Caputo, DS Alonzi, JC Hill, KC Dent, A Kumar, ... Proceedings of the National Academy of Sciences 114 (32), 8544-8549, 2017 | 57 | 2017 |
| COVID moonshot: open science discovery of SARS-CoV-2 main protease inhibitors by combining crowdsourcing, high-throughput experiments, computational simulations, and machine … H Achdout, A Aimon, E Bar-David, GM Morris BioRxiv, 2020 | 55 | 2020 |
| Biological activity, membrane‐targeting modification, and crystallization of soluble human decay accelerating factor expressed in E. coli J White, P Lukacik, D Esser, M Steward, N Giddings, JR Bright, ... Protein science 13 (9), 2406-2415, 2004 | 50 | 2004 |
| Alkyne derivatives of SARS-CoV-2 main protease inhibitors including nirmatrelvir inhibit by reacting covalently with the Nucleophilic Cysteine L Brewitz, L Dumjahn, Y Zhao, CD Owen, SM Laidlaw, TR Malla, ... Journal of Medicinal Chemistry 66 (4), 2663-2680, 2023 | 48 | 2023 |
Pietro RoversiItalian National Research Council (CNR) Institute of agricultural biology and biotechnology (IBBA)Verificeret mail på ibba.cnr.it