| The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism JM Murphy, PE Czabotar, JM Hildebrand, IS Lucet, JG Zhang, ... Immunity 39 (3), 443-453, 2013 | 1257 | 2013 |
| Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death JM Hildebrand, MC Tanzer, IS Lucet, SN Young, SK Spall, P Sharma, ... Proceedings of the National Academy of Sciences 111 (42), 15072-15077, 2014 | 602 | 2014 |
| The molecular basis of JAK/STAT inhibition by SOCS1 NPD Liau, A Laktyushin, IS Lucet, JM Murphy, S Yao, E Whitlock, ... Nature communications 9 (1), 1558, 2018 | 435 | 2018 |
| The molecular regulation of Janus kinase (JAK) activation JJ Babon, IS Lucet, JM Murphy, NA Nicola, LN Varghese Biochemical Journal 462 (1), 1-13, 2014 | 397 | 2014 |
| The structural basis of Janus kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor IS Lucet, E Fantino, M Styles, R Bamert, O Patel, SE Broughton, M Walter, ... Blood 107 (1), 176-183, 2006 | 338 | 2006 |
| Suppression of cytokine signaling by SOCS3: characterization of the mode of inhibition and the basis of its specificity JJ Babon, NJ Kershaw, JM Murphy, LN Varghese, A Laktyushin, ... Immunity 36 (2), 239-250, 2012 | 335 | 2012 |
| SOCS3 binds specific receptor–JAK complexes to control cytokine signaling by direct kinase inhibition NJ Kershaw, JM Murphy, NPD Liau, LN Varghese, A Laktyushin, ... Nature structural & molecular biology 20 (4), 469-476, 2013 | 328 | 2013 |
| Open source drug discovery with the malaria box compound collection for neglected diseases and beyond WC Van Voorhis, JH Adams, R Adelfio, V Ahyong, MH Akabas, P Alano, ... PLoS pathogens 12 (7), e1005763, 2016 | 316 | 2016 |
| A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties JM Murphy, Q Zhang, SN Young, ML Reese, FP Bailey, PA Eyers, ... Biochemical Journal 457 (2), 323-334, 2014 | 290 | 2014 |
| Dissecting specificity in the Janus kinases: the structures of JAK-specific inhibitors complexed to the JAK1 and JAK2 protein tyrosine kinase domains NK Williams, RS Bamert, O Patel, C Wang, PM Walden, AF Wilks, ... Journal of molecular biology 387 (1), 219-232, 2009 | 278 | 2009 |
| Differential recognition of CD1d-α-galactosyl ceramide by the Vβ8. 2 and Vβ7 semi-invariant NKT T cell receptors DG Pellicci, O Patel, L Kjer-Nielsen, SS Pang, LC Sullivan, ... Immunity 31 (1), 47-59, 2009 | 270 | 2009 |
| Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis EJ Petrie, JJ Sandow, AV Jacobsen, BJ Smith, MDW Griffin, IS Lucet, ... Nature communications 9 (1), 2422, 2018 | 195 | 2018 |
| Cytological and biochemical characterization of the FtsA cell division protein of Bacillus subtilis A Feucht, I Lucet, MD Yudkin, J Errington Molecular microbiology 40 (1), 115-125, 2001 | 188 | 2001 |
| HSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death AV Jacobsen, KN Lowes, MC Tanzer, IS Lucet, JM Hildebrand, EJ Petrie, ... Cell death & disease 7 (1), e2051-e2051, 2016 | 168 | 2016 |
| Eph receptor signalling: from catalytic to non-catalytic functions LY Liang, O Patel, PW Janes, JM Murphy, IS Lucet Oncogene 38 (39), 6567-6584, 2019 | 133 | 2019 |
| Molecular mechanism of CCAAT-enhancer binding protein recruitment by the TRIB1 pseudokinase JM Murphy, Y Nakatani, SA Jamieson, W Dai, IS Lucet, PD Mace Structure 23 (11), 2111-2121, 2015 | 129 | 2015 |
| Insights into the evolution of divergent nucleotide-binding mechanisms among pseudokinases revealed by crystal structures of human and mouse MLKL JM Murphy, IS Lucet, JM Hildebrand, MC Tanzer, SN Young, P Sharma, ... Biochemical Journal 457 (3), 369-377, 2014 | 115 | 2014 |
| Genome-wide binding and mechanistic analyses of Smchd1-mediated epigenetic regulation K Chen, J Hu, DL Moore, R Liu, SA Kessans, K Breslin, IS Lucet, A Keniry, ... Proceedings of the National Academy of Sciences 112 (27), E3535-E3544, 2015 | 114 | 2015 |
| Plasmodium Kinases As Targets For New-Generation Antimalarials IS Lucet, A Tobin, D Drewry, AF Wilks, C Doerig Future medicinal chemistry 4 (18), 2295-2310, 2012 | 103 | 2012 |
| Viral MLKL homologs subvert necroptotic cell death by sequestering cellular RIPK3 EJ Petrie, JJ Sandow, WIL Lehmann, LY Liang, D Coursier, SN Young, ... Cell reports 28 (13), 3309-3319. e5, 2019 | 98 | 2019 |
