John R. Engen

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Thomas E. WalesResearch Professor, Northeastern UniversityBestätigte E-Mail-Adresse bei neu.edu
Roxana IacobResearch Associate Professor, Northeastern UniversityBestätigte E-Mail-Adresse bei neu.edu
Thomas E. SmithgallUniversity of PittsburghBestätigte E-Mail-Adresse bei pitt.edu
Loren D. WalenskyProfessor of Pediatrics, Dana-Farber Cancer Institute and Harvard Medical SchoolBestätigte E-Mail-Adresse bei dfci.harvard.edu
Nathanael S. GrayProfessor of Chemical and Systems BiologyBestätigte E-Mail-Adresse bei stanford.edu
Jamie A. MorocoPrincipal Scientist, Photys TherapeuticsBestätigte E-Mail-Adresse bei photys.com
Amy AndreottiBestätigte E-Mail-Adresse bei iastate.edu
Timothy SpringerHarvard Medical School, Childrens Hospital BostonBestätigte E-Mail-Adresse bei crystal.harvard.edu
Jarrod A. MartoDana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical SchoolBestätigte E-Mail-Adresse bei dfci.harvard.edu
Pasi JanneDana Farber Cancer InstituteBestätigte E-Mail-Adresse bei dfci.harvard.edu
Ken WestoverAssociate Professor of Biochemistry and Radiation Oncology, UT SouthwesternBestätigte E-Mail-Adresse bei utsouthwestern.edu
Miklos GuttmanUniversity of Washington, SeattleBestätigte E-Mail-Adresse bei uw.edu
Daniele PeterlePeptoneBestätigte E-Mail-Adresse bei peptone.io
Ulrich HartlDirector, Max Planck Institute of BiochemistryBestätigte E-Mail-Adresse bei biochem.mpg.de
olga gurskyProfessor of Physiology and Biophysics, Boston University School of MedicineBestätigte E-Mail-Adresse bei bu.edu
Stephen BlacklowHarvard Medical SchoolBestätigte E-Mail-Adresse bei hms.harvard.edu
M. Hayer-Hartl; M.K. Hayer; M.K. Haye...Max Planck Institute of BiochemistryBestätigte E-Mail-Adresse bei biochem.mpg.de
Giulio Superti-FurgaScientific Director, CeMM Research Center for Molecular Medicine of the Austrian Academy ofBestätigte E-Mail-Adresse bei cemm.oeaw.ac.at
Stephen RagsdaleUniversity of MichiganBestätigte E-Mail-Adresse bei umich.edu
James BradnerAmgen | EVP R&D and CSO

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John R. Engen

James L. Waters Chair & Distinguished Professor of Chemistry, Northeastern University

Bestätigte E-Mail-Adresse bei neu.edu - Startseite

Protein conformation mass spectrometry hydrogen exchange HDX-MS


Titel Nach Zitationen sortieren Nach Jahr sortieren Nach Titel sortieren	Zitiert von Zitiert von	Jahr
Novel mutant-selective EGFR kinase inhibitors against EGFR T790M W Zhou, D Ercan, L Chen, CH Yun, D Li, M Capelletti, AB Cortot, ... Nature 462 (7276), 1070-1074, 2009	1212	2009
Hydrogen exchange mass spectrometry for the analysis of protein dynamics TE Wales, JR Engen Mass spectrometry reviews 25 (1), 158-170, 2006	1010	2006
Targeting Bcr–Abl by combining allosteric with ATP-binding-site inhibitors J Zhang, FJ Adrián, W Jahnke, SW Cowan-Jacob, AG Li, RE Iacob, T Sim, ... Nature 463 (7280), 501-506, 2010	716	2010
Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments GR Masson, JE Burke, NG Ahn, GS Anand, C Borchers, S Brier, ... Nature Methods 16 (7), 595-602, 2019	642	2019
Analytical tools for characterizing biopharmaceuticals and the implications for biosimilars SA Berkowitz, JR Engen, JR Mazzeo, GB Jones Nature Reviews Drug Discovery 11 (7), 527-540, 2012	635	2012
Post-translational modifications differentially affect IgG1 conformation and receptor binding D Houde, Y Peng, SA Berkowitz, JR Engen Molecular & Cellular Proteomics 9 (8), 1716-1728, 2010	480	2010
Analysis of protein conformation and dynamics by hydrogen/deuterium exchange MS JR Engen Analytical chemistry 81 (19), 7870-7875, 2009	458	2009
The utility of hydrogen/deuterium exchange mass spectrometry in biopharmaceutical comparability studies D Houde, SA Berkowitz, JR Engen Journal of pharmaceutical sciences 100 (6), 2071-2086, 2011	403	2011
High-speed and high-resolution UPLC separation at zero degrees Celsius TE Wales, KE Fadgen, GC Gerhardt, JR Engen Analytical chemistry 80 (17), 6815-6820, 2008	393	2008
Therapeutic Targeting of Oncogenic K‐Ras by a Covalent Catalytic Site Inhibitor SM Lim, KD Westover, SB Ficarro, RA Harrison, HG Choi, ME Pacold, ... Angewandte Chemie International Edition 53 (1), 199-204, 2014	364	2014
Rpn1 provides adjacent receptor sites for substrate binding and deubiquitination by the proteasome Y Shi, X Chen, S Elsasser, BB Stocks, G Tian, BH Lee, Y Shi, N Zhang, ... Science 351 (6275), aad9421, 2016	323	2016
Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors W Yu, EJ Chory, AK Wernimont, W Tempel, A Scopton, A Federation, ... Nature Communications 3, 1288, 2012	305	2012
Semi-automated data processing of hydrogen exchange mass spectra using HX-Express DD Weis, JR Engen, IJ Kass Journal of the American Society for Mass Spectrometry 17, 1700-1703, 2006	302	2006
Investigating Protein Structure and Dynamics by Hydrogen Exchange MS JR Engen, DL Smith Analytical chemistry 73 (9), 256-265, 2001	300	2001
Substrate processing by the Cdc48 ATPase complex is initiated by ubiquitin unfolding EC Twomey, Z Ji, TE Wales, NO Bodnar, SB Ficarro, JA Marto, JR Engen, ... Science 365 (6452), eaax1033, 2019	286	2019
Force interacts with macromolecular structure in activation of TGF-β X Dong, B Zhao, RE Iacob, J Zhu, AC Koksal, C Lu, JR Engen, ... Nature 542 (7639), 55-59, 2017	285	2017
Characterization of IgG1 conformation and conformational dynamics by hydrogen/deuterium exchange mass spectrometry D Houde, J Arndt, W Domeier, S Berkowitz, JR Engen Analytical chemistry 81 (7), 2644-2651, 2009	283	2009
Identification and characterization of EX1 kinetics in H/D exchange mass spectrometry by peak width analysis DD Weis, TE Wales, JR Engen, M Hotchko, LF Ten Eyck Journal of the American Society for Mass Spectrometry 17, 1498-1509, 2006	263	2006
Design of stapled antimicrobial peptides that are stable, nontoxic and kill antibiotic-resistant bacteria in mice R Mourtada, HD Herce, DJ Yin, JA Moroco, TE Wales, JR Engen, ... Nature Biotechnology 37 (10), 1186-1197, 2019	244	2019
Hydrogen/deuterium exchange mass spectrometry for probing higher order structure of protein therapeutics: methodology and applications H Wei, J Mo, L Tao, RJ Russell, AA Tymiak, G Chen, RE Iacob, JR Engen Drug discovery today 19 (1), 95-102, 2014	241	2014

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