| Differential compartmentalization and distinct functions of GABAB receptor variants R Vigot, S Barbieri, H Bräuner-Osborne, R Turecek, R Shigemoto, ... Neuron 50 (4), 589-601, 2006 | 383 | 2006 |
| Induction of cerebral β-amyloidosis: intracerebral versus systemic Aβ inoculation YS Eisele, T Bolmont, M Heikenwalder, F Langer, LH Jacobson, ZX Yan, ... Proceedings of the National Academy of Sciences 106 (31), 12926-12931, 2009 | 334 | 2009 |
| The second-generation active Aβ immunotherapy CAD106 reduces amyloid accumulation in APP transgenic mice while minimizing potential side effects C Wiessner, KH Wiederhold, AC Tissot, P Frey, S Danner, LH Jacobson, ... Journal of Neuroscience 31 (25), 9323-9331, 2011 | 233 | 2011 |
| Feeling strained? Influence of genetic background on depression-related behavior in mice: a review LH Jacobson, JF Cryan Behavior genetics 37, 171-213, 2007 | 227 | 2007 |
| The BACE‐1 inhibitor CNP 520 for prevention trials in Alzheimer's disease U Neumann, M Ufer, LH Jacobson, ML Rouzade‐Dominguez, G Huledal, ... EMBO molecular medicine 10 (11), e9316, 2018 | 180 | 2018 |
| An antagonist to vasoactive intestinal peptide affects cellular functions in the central nervous system. I Gozes, SK McCune, L Jacobson, D Warren, TW Moody, M Fridkin, ... The Journal of pharmacology and experimental therapeutics 257 (3), 959-966, 1991 | 172 | 1991 |
| mGluR7 facilitates extinction of aversive memories and controls amygdala plasticity M Fendt, S Schmid, DR Thakker, LH Jacobson, R Yamamoto, ... Molecular psychiatry 13 (10), 970-979, 2008 | 149 | 2008 |
| Selective NaV1. 1 activation rescues Dravet syndrome mice from seizures and premature death KL Richards, CJ Milligan, RJ Richardson, N Jancovski, M Grunnet, ... Proceedings of the National Academy of Sciences 115 (34), E8077-E8085, 2018 | 145 | 2018 |
| Default mode network modulation by psychedelics: a systematic review JJ Gattuso, D Perkins, S Ruffell, AJ Lawrence, D Hoyer, LH Jacobson, ... International Journal of Neuropsychopharmacology 26 (3), 155-188, 2023 | 142 | 2023 |
| A novel BACE inhibitor NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice U Neumann, H Rueeger, R Machauer, SJ Veenstra, RM Lueoend, ... Molecular neurodegeneration 10, 1-15, 2015 | 142 | 2015 |
| Orexin in sleep, addiction and more: is the perfect insomnia drug at hand? D Hoyer, LH Jacobson Neuropeptides 47 (6), 477-488, 2013 | 130 | 2013 |
| Discovery of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors: structure-based design and in vivo reduction of amyloid … H Rueeger, R Lueoend, O Rogel, JM Rondeau, H Möbitz, R Machauer, ... Journal of Medicinal Chemistry 55 (7), 3364-3386, 2012 | 121 | 2012 |
| Identification of a novel series of orexin receptor antagonists with a distinct effect on sleep architecture for the treatment of insomnia C Betschart, S Hintermann, D Behnke, S Cotesta, M Fendt, CE Gee, ... Journal of medicinal chemistry 56 (19), 7590-7607, 2013 | 103 | 2013 |
| Behavioral evaluation of mice deficient in GABAB (1) receptor isoforms in tests of unconditioned anxiety LH Jacobson, B Bettler, K Kaupmann, JF Cryan Psychopharmacology 190 (4), 541-553, 2007 | 96 | 2007 |
| BACE1 inhibition induces a specific cerebrospinal fluid β-amyloid pattern that identifies drug effects in the central nervous system N Mattsson, L Rajendran, H Zetterberg, M Gustavsson, U Andreasson, ... PloS one 7 (2), e31084, 2012 | 83 | 2012 |
| Evaluation of the anxiolytic-like profile of the GABAB receptor positive modulator CGP7930 in rodents LH Jacobson, JF Cryan Neuropharmacology 54 (5), 854-862, 2008 | 82 | 2008 |
| Pharmacological BACE1 and BACE2 inhibition induces hair depigmentation by inhibiting PMEL17 processing in mice DR Shimshek, LH Jacobson, C Kolly, N Zamurovic, KK Balavenkatraman, ... Scientific reports 6 (1), 21917, 2016 | 81 | 2016 |
| Enhanced proteolytic clearance of plasma Aβ by peripherally administered neprilysin does not result in reduced levels of brain Aβ in mice JR Walker, R Pacoma, J Watson, W Ou, J Alves, DE Mason, EC Peters, ... Journal of Neuroscience 33 (6), 2457-2464, 2013 | 77 | 2013 |
| GABAB (1) receptor isoforms differentially mediate the acquisition and extinction of aversive taste memories LH Jacobson, PH Kelly, B Bettler, K Kaupmann, JF Cryan Journal of Neuroscience 26 (34), 8800-8803, 2006 | 73 | 2006 |
| Hypocretins (orexins): The ultimate translational neuropeptides LH Jacobson, D Hoyer, L de Lecea Journal of Internal Medicine 291 (5), 533-556, 2022 | 71 | 2022 |
John CryanUniversity College Cork, IrelandBestätigte E-Mail-Adresse bei ucc.ie
