| N-(5-Chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5- (tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine, a Novel, Highly Selective, Orally … LF Hennequin, J Allen, J Breed, J Curwen, M Fennell, TP Green, ... Journal of medicinal chemistry 49 (22), 6465-6488, 2006 | 406 | 2006 |
| AZD9496: An Oral Estrogen Receptor Inhibitor That Blocks the Growth of ER-Positive and ESR1-Mutant Breast Tumors in Preclinical Models HM Weir, RH Bradbury, M Lawson, AA Rabow, D Buttar, RJ Callis, ... Cancer research 76 (11), 3307-3318, 2016 | 218 | 2016 |
| Computational approaches to therapeutic antibody design: established methods and emerging trends RA Norman, F Ambrosetti, AMJJ Bonvin, LJ Colwell, S Kelm, S Kumar, ... Briefings in bioinformatics 21 (5), 1549-1567, 2020 | 200 | 2020 |
| Optimization of a Novel Binding Motif to (E)-3-(3,5-Difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl … C De Savi, RH Bradbury, AA Rabow, RA Norman, C de Almeida, ... Journal of medicinal chemistry 58 (20), 8128-8140, 2015 | 192 | 2015 |
| Design and synthesis of novel lactate dehydrogenase A inhibitors by fragment-based lead generation RA Ward, C Brassington, AL Breeze, A Caputo, S Critchlow, G Davies, ... Journal of medicinal chemistry 55 (7), 3285-3306, 2012 | 187 | 2012 |
| Imidazo [1, 2-a] pyridines: a potent and selective class of cyclin-dependent kinase inhibitors identified through structure-based hybridisation M Anderson, JF Beattie, GA Breault, J Breed, KF Byth, JD Culshaw, ... Bioorganic & Medicinal Chemistry Letters 13 (18), 3021-3026, 2003 | 152 | 2003 |
| Landscape of activating cancer mutations in FGFR kinases and their differential responses to inhibitors in clinical use H Patani, TD Bunney, N Thiyagarajan, RA Norman, D Ogg, J Breed, ... Oncotarget 7 (17), 24252, 2016 | 125 | 2016 |
| Structural insights into FGFR kinase isoform selectivity: diverse binding modes of AZD4547 and ponatinib in complex with FGFR1 and FGFR4 JA Tucker, T Klein, J Breed, AL Breeze, R Overman, C Phillips, ... Structure 22 (12), 1764-1774, 2014 | 118 | 2014 |
| Crystal structure of human thymidine phosphorylase in complex with a small molecule inhibitor RA Norman, ST Barry, M Bate, J Breed, JG Colls, RJ Ernill, RWA Luke, ... Structure 12 (1), 75-84, 2004 | 114 | 2004 |
| The Mycobacterium tuberculosis ino1 gene is essential for growth and virulence F Movahedzadeh, DA Smith, RA Norman, P Dinadayala, J Murray‐Rust, ... Molecular microbiology 51 (4), 1003-1014, 2004 | 114 | 2004 |
| Prevention of MKK6-dependent activation by binding to p38α MAP kinase JE Sullivan, GA Holdgate, D Campbell, D Timms, S Gerhardt, J Breed, ... Biochemistry 44 (50), 16475-16490, 2005 | 112 | 2005 |
| Crystal structure and induction mechanism of AmiC–AmiR: a ligand‐regulated transcription antitermination complex BP O'Hara, RA Norman, PTC Wan, SM Roe, TE Barrett, RE Drew, ... The EMBO journal, 1999 | 110 | 1999 |
| Structural approaches to obtain kinase selectivity RA Norman, D Toader, AD Ferguson Trends in pharmacological sciences 33 (5), 273-278, 2012 | 104 | 2012 |
| Imidazo [1, 2-b] pyridazines: a potent and selective class of cyclin-dependent kinase inhibitors KF Byth, N Cooper, JD Culshaw, DW Heaton, SE Oakes, CA Minshull, ... Bioorganic & medicinal chemistry letters 14 (9), 2249-2252, 2004 | 94 | 2004 |
| Structural and dynamic insights into the energetics of activation loop rearrangement in FGFR1 kinase T Klein, N Vajpai, JJ Phillips, G Davies, GA Holdgate, C Phillips, ... Nature communications 6 (1), 7877, 2015 | 77 | 2015 |
| Crystal structure of inositol 1-phosphate synthase from Mycobacterium tuberculosis, a key enzyme in phosphatidylinositol synthesis RA Norman, MSB McAlister, J Murray-Rust, F Movahedzadeh, NG Stoker, ... Structure 10 (3), 393-402, 2002 | 77 | 2002 |
| Transcription antitermination regulation of the Pseudomonas aeruginosa amidase operon. SA Wilson, SJ Wachira, RA Norman, LH Pearl, RE Drew The EMBO Journal 15 (21), 5907-5916, 1996 | 64 | 1996 |
| Investigation of (E)-3-[4-(2-Oxo-3-aryl-chromen-4-yl)oxyphenyl]acrylic Acids as Oral Selective Estrogen Receptor Down-Regulators SL Degorce, A Bailey, R Callis, C De Savi, R Ducray, G Lamont, ... Journal of Medicinal Chemistry 58 (8), 3522-3533, 2015 | 53 | 2015 |
| Multi-objective design of a hybrid propulsion system for marine vessels EA Sciberras, RA Norman IET electrical systems in transportation 2 (3), 148-157, 2012 | 45 | 2012 |
| Protein–ligand crystal structures can guide the design of selective inhibitors of the FGFR tyrosine kinase RA Norman, AK Schott, DM Andrews, J Breed, KM Foote, AP Garner, ... Journal of medicinal chemistry 55 (11), 5003-5012, 2012 | 42 | 2012 |
