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King L Hung
King L Hung
Bestätigte E-Mail-Adresse bei scripps.edu - Startseite
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Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing
JK Nuñez, J Chen, GC Pommier, JZ Cogan, JM Replogle, C Adriaens, ...
Cell 184 (9), 2503-2519. e17, 2021
5332021
ecDNA hubs drive cooperative intermolecular oncogene expression
KL Hung, KE Yost, L Xie, Q Shi, K Helmsauer, J Luebeck, R Schöpflin, ...
Nature 600 (7890), 731-736, 2021
2212021
Engineering protein-secreting plasma cells by homology-directed repair in primary human B cells
KL Hung, I Meitlis, M Hale, CY Chen, S Singh, SW Jackson, CH Miao, ...
Molecular Therapy 26 (2), 456-467, 2018
1302018
The evolutionary dynamics of extrachromosomal DNA in human cancers
JT Lange, JC Rose, CY Chen, Y Pichugin, L Xie, J Tang, KL Hung, ...
Nature Genetics 54 (10), 1527-1533, 2022
118*2022
Targeted profiling of human extrachromosomal DNA by CRISPR-CATCH
KL Hung, J Luebeck, SR Dehkordi, CI Colón, R Li, ITL Wong, C Coruh, ...
Nature Genetics 54, 1746-1754, 2022
872022
Wnt signaling and tbx16 form a bistable switch to commit bipotential progenitors to mesoderm
CM Bouldin, AJ Manning, YH Peng, GH Farr III, KL Hung, A Dong, ...
Development 142 (14), 2499-2507, 2015
642015
A functional taxonomy of tumor suppression in oncogenic KRAS–driven lung cancer
H Cai, SK Chew, C Li, MK Tsai, L Andrejka, CW Murray, NW Hughes, ...
Cancer discovery 11 (7), 1754-1773, 2021
472021
Parallel sequencing of extrachromosomal circular DNAs and transcriptomes in single cancer cells
R Chamorro González, T Conrad, MC Stöber, R Xu, M Giurgiu, ...
Nature Genetics 55 (5), 880-890, 2023
442023
Gene regulation on extrachromosomal DNA
KL Hung, PS Mischel, HY Chang
Nature structural & molecular biology 29 (8), 736-744, 2022
332022
The AAV capsid can influence the epigenetic marking of rAAV delivered episomal genomes in a species dependent manner
A Gonzalez-Sandoval, K Pekrun, S Tsuji, F Zhang, KL Hung, HY Chang, ...
Nature Communications 14 (1), 2448, 2023
302023
Ex vivo engineered human plasma cells exhibit robust protein secretion and long-term engraftment in vivo
RYH Cheng, KL Hung, T Zhang, CM Stoffers, AR Ott, ER Suchland, ...
Nature Communications 13 (1), 6110, 2022
292022
Circular extrachromosomal DNA promotes tumor heterogeneity in high-risk medulloblastoma
OS Chapman, J Luebeck, S Sridhar, ITL Wong, D Dixit, S Wang, G Prasad, ...
Nature genetics 55 (12), 2189-2199, 2023
172023
Coordinated inheritance of extrachromosomal DNAs in cancer cells
KL Hung, MG Jones, ITL Wong, EJ Curtis, JT Lange, BJ He, J Luebeck, ...
Nature 635 (8037), 201-209, 2024
11*2024
Oncogene convergence in extrachromosomal DNA hubs
NE Weiser, KL Hung, HY Chang
Cancer discovery 12 (5), 1195-1198, 2022
82022
132. Targeting the BTK locus in primary human hematopoietic cells with TALENs and AAV donor template
C Clough, Y Wang, IF Khan, S Singh, K Hung, DJ Rawlings
Molecular Therapy 24, S54, 2016
72016
Origins and impact of extrachromosomal DNA
C Bailey, O Pich, K Thol, TBK Watkins, J Luebeck, A Rowan, G Stavrou, ...
Nature 635 (8037), 193-200, 2024
62024
CoRAL accurately resolves extrachromosomal DNA genome structures with long-read sequencing
K Zhu, MG Jones, J Luebeck, X Bu, H Yi, KL Hung, ITL Wong, S Zhang, ...
Genome Research 34 (9), 1344-1354, 2024
52024
Disparate pathways for extrachromosomal DNA biogenesis and genomic DNA repair
JC Rose, JA Belk, ITL Wong, J Luebeck, HT Horn, B Daniel, MG Jones, ...
Cancer Discovery 15 (1), 69-82, 2025
32025
A STAG2-PAXIP1/PAGR1 axis suppresses lung tumorigenesis
EL Ashkin, YJ Tang, H Xu, KL Hung, JA Belk, H Cai, SS Lopez, ...
Journal of Experimental Medicine 222 (1), e20240765, 2024
12024
569. Precision Editing of the WAS Locus via Homologous Recombination in Primary Human Hematopoietic Cells Mediated by Either TALEN or CRISPR/Cas Nucleases
IF Khan, Y Wang, C Clough, S Singh, K Hung, DJ Rawlings
Molecular Therapy 24, S227, 2016
12016
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