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Nicole Maphis
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Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain
N Maphis, G Xu, ON Kokiko-Cochran, S Jiang, A Cardona, RM Ransohoff, ...
Brain 138 (6), 1738-1755, 2015
5532015
Microglial derived tumor necrosis factor-α drives Alzheimer's disease-related neuronal cell cycle events
K Bhaskar, N Maphis, G Xu, NH Varvel, ON Kokiko-Cochran, JP Weick, ...
Neurobiology of disease 62, 273-285, 2014
1772014
Pharmaceutical screen identifies novel target processes for activation of autophagy with a broad translational potential
S Chauhan, Z Ahmed, SB Bradfute, J Arko-Mensah, MA Mandell, ...
Nature communications 6 (1), 8620, 2015
1532015
Selective suppression of the α isoform of p38 MAPK rescues late-stage tau pathology
N Maphis, S Jiang, G Xu, ON Kokiko-Cochran, SM Roy, LJ Van Eldik, ...
Alzheimer's research & therapy 8, 1-15, 2016
1222016
Loss of tau rescues inflammation-mediated neurodegeneration
N Maphis, G Xu, ON Kokiko-Cochran, AE Cardona, RM Ransohoff, ...
Frontiers in neuroscience 9, 196, 2015
962015
Hypoxia promotes tau hyperphosphorylation with associated neuropathology in vascular dysfunction
L Raz, K Bhaskar, J Weaver, S Marini, Q Zhang, JF Thompson, ...
Neurobiology of disease 126, 124-136, 2019
892019
Proteopathic tau primes and activates interleukin-1β via myeloid-cell-specific MyD88-and NLRP3-ASC-inflammasome pathway
S Jiang, NM Maphis, J Binder, D Chisholm, L Weston, W Duran, ...
Cell reports 36 (12), 2021
662021
Machine learning prediction and tau-based screening identifies potential Alzheimer’s disease genes relevant to immunity
J Binder, O Ursu, C Bologa, S Jiang, N Maphis, S Dadras, D Chisholm, ...
Communications Biology 5 (1), 125, 2022
422022
Qß Virus-like particle-based vaccine induces robust immunity and protects against tauopathy
NM Maphis, J Peabody, E Crossey, S Jiang, FA Jamaleddin Ahmad, ...
npj Vaccines 4 (1), 26, 2019
422019
Whole genome expression analysis in a mouse model of tauopathy identifies MECP2 as a possible regulator of tau pathology
NM Maphis, S Jiang, J Binder, C Wright, B Gopalan, BT Lamb, K Bhaskar
Frontiers in molecular neuroscience 10, 69, 2017
322017
Photoreceptor degeneration, azoospermia, leukoencephalopathy, and abnormal RPE cell function in mice expressing an early stop mutation in CLCN2
MM Edwards, CM de Evsikova, GB Collin, E Gifford, J Wu, WL Hicks, ...
Investigative ophthalmology & visual science 51 (6), 3264-3272, 2010
312010
Genetically enhancing the expression of chemokine domain of CX3CL1 fails to prevent tau pathology in mouse models of tauopathy
SM Bemiller, NM Maphis, SV Formica, GN Wilson, CM Miller, G Xu, ...
Journal of Neuroinflammation 15, 1-11, 2018
212018
The development, but not expression, of alcohol front‐loading in C57BL/6J mice maintained on LabDiet 5001 is abolished by maintenance on Teklad 2920x rodent diet
NM Maphis, RT Huffman, DN Linsenbardt
Alcoholism: Clinical and Experimental Research 46 (7), 1321-1330, 2022
162022
Selective In Vitro and Ex Vivo Staining of Brain Neurofibrillary Tangles and Amyloid Plaques by Novel Ethylene Ethynylene-Based Optical Sensors
FA Monge, AM Fanni, PL Donabedian, J Hulse, NM Maphis, S Jiang, ...
Biosensors 13 (2), 151, 2023
22023
Binding-Activated Superradiant Probes for Amyloid in Solution and Tissue
P Donabedian, N Maphis, S Jiang, K Bhaskar, D Whitten, E Chi
Biophysical Journal 110 (3), 554a, 2016
12016
Tau vaccines differentially target tau pathologies in Alzheimer’s disease and primary tauopathies
JP Hulse, M Whelpley, NM Maphis, J Peabody, B Chackerian, K Bhaskar
Alzheimer's & Dementia 20, e095353, 2024
2024
Immunotherapy compositions and methods for treatment of tauopathy and transgenic mouse
K Bhaskar, N Maphis, DS Peabody, B Chackerian, J Peabody, E Crossey
US Patent App. 18/636,216, 2024
2024
Immunotherapy compositions and methods for treatment of tauopathy and transgenic mouse
K Bhaskar, N Maphis, DS Peabody, B Chackerian, J Peabody, E Crossey
US Patent App. 18/402,899, 2024
2024
Virus-like particle (VLP)-based vaccine targeting tau phosphorylated at Ser396/Ser404 (PHF1) site outperforms phosphorylated S199/S202 (AT8) site in reducing tau pathology and …
J Hulse, N Maphis, J Peabody, B Chackerian, K Bhaskar
Research Square, rs. 3. rs-4390998, 2024
2024
Alcohol Consumption During Early Adulthood in a Preclinical Mouse Model of Alzheimer’s Disease Leads to Gait Impairments, Dysregulated Circadian Rhythm, Alterations in …
NM Maphis, D Furlano, SA David, DN Linsebardt
2023
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