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Tom Wennekes
Tom Wennekes
Utrecht University, Department of Chemical Biology and Drug Discovery
Bestätigte E-Mail-Adresse bei uu.nl - Startseite
Titel
Zitiert von
Zitiert von
Jahr
Multivalent glycoconjugates as anti-pathogenic agents
A Bernardi, J Jiménez-Barbero, A Casnati, C De Castro, T Darbre, ...
Chemical Society Reviews 42 (11), 4709-4727, 2013
5932013
Glycosphingolipids—nature, function, and pharmacological modulation
T Wennekes, RJ van den Berg, RG Boot, GA van der Marel, HS Overkleeft, ...
Angewandte Chemie International Edition 48 (47), 8848-8869, 2009
3682009
Pharmacological inhibition of glucosylceramide synthase enhances insulin sensitivity
JM Aerts, R Ottenhoff, AS Powlson, A Grefhorst, M Van Eijk, ...
Diabetes 56 (5), 1341-1349, 2007
3452007
Identification of the non-lysosomal glucosylceramidase as β-glucosidase 2
RG Boot, M Verhoek, W Donker-Koopman, A Strijland, J van Marle, ...
Journal of Biological Chemistry 282 (2), 1305-1312, 2007
2442007
Mechanism-based covalent neuraminidase inhibitors with broad-spectrum influenza antiviral activity
JH Kim, R Resende, T Wennekes, HM Chen, N Bance, S Buchini, ...
Science 340 (6128), 71-75, 2013
2222013
Development of adamantan-1-yl-methoxy-functionalized 1-deoxynojirimycin derivatives as selective inhibitors of glucosylceramide metabolism in man
T Wennekes, RJ van den Berg, W Donker, GA van der Marel, A Strijland, ...
The Journal of organic chemistry 72 (4), 1088-1097, 2007
1722007
Hydrolytic and thermal stability of organic monolayers on various inorganic substrates
NS Bhairamadgi, SP Pujari, FG Trovela, A Debrassi, AA Khamis, ...
Langmuir 30 (20), 5829-5839, 2014
1202014
Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation
T Wennekes, AJ Meijer, AK Groen, RG Boot, JE Groener, M van Eijk, ...
Journal of medicinal chemistry 53 (2), 689-698, 2010
1162010
N-glycolylneuraminic acid as a receptor for influenza A viruses
F Broszeit, N Tzarum, X Zhu, N Nemanichvili, D Eggink, T Leenders, Z Li, ...
Cell reports 27 (11), 3284-3294. e6, 2019
1002019
A protein‐based pentavalent inhibitor of the cholera toxin B‐subunit
TR Branson, TE McAllister, J Garcia‐Hartjes, MA Fascione, JF Ross, ...
Angewandte Chemie 126 (32), 8463-8467, 2014
992014
Structural and mechanistic insight into N-glycan processing by endo-α-mannosidase
AJ Thompson, RJ Williams, Z Hakki, DS Alonzi, T Wennekes, TM Gloster, ...
Proceedings of the National Academy of Sciences 109 (3), 781-786, 2012
902012
A fluorescence polarization activity-based protein profiling assay in the discovery of potent, selective inhibitors for human nonlysosomal glucosylceramidase
D Lahav, B Liu, RJ van den Berg, AMCH van den Nieuwendijk, ...
Journal of the American Chemical Society 139 (40), 14192-14197, 2017
762017
The cytosolic β-glucosidase GBA3 does not influence type 1 Gaucher disease manifestation
N Dekker, T Voorn-Brouwer, M Verhoek, T Wennekes, RS Narayan, ...
Blood Cells, Molecules, and Diseases 46 (1), 19-26, 2011
752011
Glycosphingolipids and insulin resistance
JM Aerts, RG Boot, M van Eijk, J Groener, N Bijl, E Lombardo, FM Bietrix, ...
Sphingolipids and metabolic disease, 99-119, 2011
712011
Getting a grip on glycans: a current overview of the metabolic oligosaccharide engineering toolbox
TJ Sminia, H Zuilhof, T Wennekes
Carbohydrate research 435, 121-141, 2016
662016
Identification and development of biphenyl substituted iminosugars as improved dual glucosylceramide synthase/neutral glucosylceramidase inhibitors
AT Ghisaidoobe, RJ van den Berg, SS Butt, A Strijland, ...
Journal of medicinal chemistry 57 (21), 9096-9104, 2014
652014
Picomolar inhibition of cholera toxin by a pentavalent ganglioside GM1os-calix [5] arene
J Garcia-Hartjes, S Bernardi, CAGM Weijers, T Wennekes, M Gilbert, ...
Organic & biomolecular chemistry 11 (26), 4340-4349, 2013
642013
Synthesis and evaluation of dimeric lipophilic iminosugars as inhibitors of glucosylceramide metabolism
T Wennekes, RJ van den Berg, KM Bonger, WE Donker-Koopman, ...
Tetrahedron: Asymmetry 20 (6-8), 836-846, 2009
572009
Large-Scale Synthesis of the Glucosylceramide Synthase Inhibitor N-[5-(Adamantan-1-yl-methoxy)-pentyl]-1-deoxynojirimycin
T Wennekes, B Lang, M Leeman, GA Marel, E Smits, M Weber, ...
Organic Process Research & Development 12 (3), 414-423, 2008
552008
Mechanism-based inhibitors of glycosidases: design and applications
WW Kallemeijn, MD Witte, T Wennekes, JMFG Aerts
Advances in carbohydrate chemistry and biochemistry 71, 297-338, 2014
532014
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