| Selection on noise constrains variation in a eukaryotic promoter BPH Metzger, DC Yuan, JD Gruber, F Duveau, PJ Wittkopp Nature 521 (7552), 344-347, 2015 | 168 | 2015 |
| A hydrophobic ratchet entrenches molecular complexes GKA Hochberg, Y Liu, EG Marklund, BPH Metzger, A Laganowsky, ... Nature 588 (7838), 503-508, 2020 | 113 | 2020 |
| Contrasting Frequencies and Effects of cis- and trans-Regulatory Mutations Affecting Gene Expression BPH Metzger, F Duveau, DC Yuan, S Tryban, B Yang, PJ Wittkopp Molecular biology and evolution 33 (5), 1131-1146, 2016 | 106 | 2016 |
| Evolutionary dynamics of regulatory changes underlying gene expression divergence among Saccharomyces species BPH Metzger, PJ Wittkopp, J Coolon Genome Biology and Evolution 9 (4), 843-854, 2017 | 84 | 2017 |
| Fitness effects of altering gene expression noise in Saccharomyces cerevisiae F Duveau, A Hodgins-Davis, BPH Metzger, B Yang, S Tryban, EA Walker, ... Elife 7, e37272, 2018 | 71 | 2018 |
| Epistatic drift causes gradual decay of predictability in protein evolution Y Park, BPH Metzger, JW Thornton Science 376 (6595), 823-830, 2022 | 68 | 2022 |
| Contingency and chance erase necessity in the experimental evolution of ancestral proteins VC Xie, J Pu, BPH Metzger, JW Thornton, BC Dickinson Elife 10, e67336, 2021 | 55 | 2021 |
| Deciphering the genic basis of yeast fitness variation by simultaneous forward and reverse genetics CJ Maclean, BPH Metzger, JR Yang, WC Ho, B Moyers, J Zhang Molecular biology and evolution 34 (10), 2486-2502, 2017 | 49 | 2017 |
| Effects of mutation and selection on plasticity of a promoter activity in Saccharomyces cerevisiae F Duveau, DC Yuan, BPH Metzger, A Hodgins-Davis, PJ Wittkopp Proceedings of the National Academy of Sciences 114 (52), E11218-E11227, 2017 | 28 | 2017 |
| Mapping Small Effect Mutations in Saccharomyces cerevisiae: Impacts of Experimental Design and Mutational Properties F Duveau, BPH Metzger, JD Gruber, K Mack, N Sood, TE Brooks, ... G3: Genes, Genomes, Genetics 4 (7), 1205-1216, 2014 | 28 | 2014 |
| Compensatory trans-regulatory alleles minimizing variation in TDH3 expression are common within Saccharomyces cerevisiae BPH Metzger, PJ Wittkopp Evolution letters 3 (5), 448-461, 2019 | 25 | 2019 |
| The simplicity of protein sequence-function relationships Y Park, BPH Metzger, JW Thornton Nature Communications 15 (1), 7953, 2024 | 23 | 2024 |
| Mutational sources of trans-regulatory variation affecting gene expression in Saccharomyces cerevisiae F Duveau, PV Zande, BPH Metzger, CJ Diaz, EA Walker, S Tryban, ... Elife 10, e67806, 2021 | 13 | 2021 |
| Epistasis facilitates functional evolution in an ancient transcription factor BPH Metzger, Y Park, TN Starr, JW Thornton Elife 12, RP88737, 2024 | 12 | 2024 |
| Frequent transitions in self-assembly across the evolution of a central metabolic enzyme FL Sendker, T Schlotthauer, CN Mais, YK Lo, M Girbig, S Bohn, T Heimerl, ... Nature Communications 15 (1), 1-13, 2024 | 1 | 2024 |
| Direct sequencing of haplotypes from diploid individuals through a modified emulsion PCR‐based single‐molecule sequencing approach BPH Metzger, GW Gelembiuk, CE Lee Molecular ecology resources 13 (1), 135-143, 2013 | 1 | 2013 |
| On the Analysis of Protein Genetic Architecture: Response to “Protein sequence landscapes are not so simple” Y Park, BPH Metzger, JW Thornton bioRxiv, 2024.09. 17.613512, 2024 | | 2024 |
| Genetic code robustness and protein evolvability are correlated and protein-specific BPH Metzger Plos Biology 22 (5), e3002627, 2024 | | 2024 |
| Disentangling the effects of mutation and selection on the evolution of gene expression BPH Metzger University of Michigan, 2015 | | 2015 |
| Response to" Protein sequence landscapes are not so simple: on reference-free versus reference-based inference" Y Park, BPH Metzger, JW Thornton Cold Spring Harbor Laboratory, 0 | | |
Patricia J WittkoppProfessor, University of MichiganBestätigte E-Mail-Adresse bei umich.edu
