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Yu Zhang
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Angiopoietin-Tie signaling pathway in endothelial cells: a computational model
Y Zhang, CD Kontos, BH Annex, AS Popel
Iscience 20, 497-511, 2019
442019
Computer simulation of TSP1 inhibition of VEGF–akt–eNOS: an angiogenesis triple threat
H Bazzazi, Y Zhang, M Jafarnejad, JS Isenberg, BH Annex, AS Popel
Frontiers in physiology 9, 644, 2018
412018
Systems biology of angiogenesis signaling: Computational models and omics
Y Zhang, H Wang, RHM Oliveira, C Zhao, AS Popel
WIREs mechanisms of disease 14 (4), e1550, 2022
332022
Three-dimensional transport model for intravitreal and suprachoroidal drug injection
Y Zhang, H Bazzazi, RL e Silva, NB Pandey, JJ Green, PA Campochiaro, ...
Investigative Ophthalmology & Visual Science 59 (12), 5266-5276, 2018
302018
Mechanistic computational models of microRNA-mediated signaling networks in human diseases
C Zhao, Y Zhang, AS Popel
International journal of molecular sciences 20 (2), 421, 2019
262019
Mechanistically detailed systems biology modeling of the HGF/Met pathway in hepatocellular carcinoma
M Jafarnejad, RJ Sové, L Danilova, AC Mirando, Y Zhang, M Yarchoan, ...
NPJ systems biology and applications 5 (1), 29, 2019
252019
Computational modeling of synergistic interaction between αVβ3 integrin and VEGFR2 in endothelial cells: Implications for the mechanism of action of angiogenesis-modulating …
H Bazzazi, Y Zhang, M Jafarnejad, AS Popel
Journal of theoretical biology 455, 212-221, 2018
232018
Using quantitative systems pharmacology modeling to optimize combination therapy of anti-PD-L1 checkpoint inhibitor and T cell engager
S Anbari, H Wang, Y Zhang, J Wang, M Pilvankar, M Nickaeen, S Hansel, ...
Frontiers in Pharmacology 14, 1163432, 2023
122023
A systems biology model of junctional localization and downstream signaling of the Ang–Tie signaling pathway
Y Zhang, CD Kontos, BH Annex, AS Popel
npj Systems Biology and Applications 7 (1), 34, 2021
112021
Dynamic multiscale regulation of perfusion recovery in experimental peripheral arterial disease: a mechanistic computational model
C Zhao, JL Heuslein, Y Zhang, BH Annex, AS Popel
Basic to Translational Science 7 (1), 28-50, 2022
92022
Eliciting the antitumor immune response with a conditionally activated PD‐L1 targeting antibody analyzed with a quantitative systems pharmacology model
A Ippolito, H Wang, Y Zhang, V Vakil, H Bazzazi, AS Popel
CPT: Pharmacometrics & Systems Pharmacology 13 (1), 93-105, 2024
72024
Combining multikinase tyrosine kinase inhibitors targeting the vascular endothelial growth factor and cluster of differentiation 47 signaling pathways is predicted to increase …
Y Zhang, AS Popel, H Bazzazi
ACS Pharmacology & Translational Science 6 (5), 710-726, 2023
62023
Signaling-biophysical modeling unravels mechanistic control of red blood cell phagocytosis by macrophages in sickle cell disease
Y Zhang, Y Qiang, H Li, G Li, L Lu, M Dao, GE Karniadakis, AS Popel, ...
PNAS nexus 3 (2), pgae031, 2024
52024
Virtual clinical trials via a QSP immuno-oncology model to simulate the response to a conditionally activated PD-L1 targeting antibody in NSCLC
A Ippolito, H Wang, Y Zhang, V Vakil, AS Popel
Journal of Pharmacokinetics and Pharmacodynamics, 1-11, 2024
12024
Systems Biology Modeling of Complex Cellular Signaling Networks in Human Diseases
Y Zhang
Johns Hopkins University, 2024
12024
Systems biology modeling of endothelial cell and macrophage signaling in angiogenesis in human diseases
Y Zhang, C Zhao, AS Popel
The Vasculome, 163-172, 2022
12022
A mechanistic systems biology model of brain microvascular endothelial cell signaling reveals dynamic pathway-based therapeutic targets for brain ischemia
G Li, Y Ma, S Zhang, W Lin, X Yao, Y Zhou, Y Zhao, Q Rao, Y Qu, Y Gao, ...
Redox Biology 78, 103415, 2024
2024
Endothelial Regulation of Microvascular Growth and Stability by Ang‐Tie and VEGF Signaling Pathways: A Mechanistic Computational Systems Biology Model
Y Zhang, CD Kontos, BH Annex, AS Popel
The FASEB Journal 36, 2022
2022
Computational Systems Biology Modeling of the Angiopoietin‐Tie Signaling Pathway and its Crosstalk with α5β1 Integrin in Endothelial Cells
Y Zhang, C Kontos, B Annex, A Popel
The FASEB Journal 35, 2021
2021
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