| Repression of smoothened by patched-dependent (pro-) vitamin D3 secretion MF Bijlsma, CA Spek, D Zivkovic, S van de Water, F Rezaee, ... PLoS biology 4 (8), e232, 2006 | 407 | 2006 |
| Nuclear receptors Nur77, Nurr1, and NOR-1 expressed in atherosclerotic lesion macrophages reduce lipid loading and inflammatory responses PI Bonta, CM Van Tiel, M Vos, TWH Pols, JV Van Thienen, V Ferreira, ... Arteriosclerosis, thrombosis, and vascular biology 26 (10), 2288-2288, 2006 | 304 | 2006 |
| The in vivo kinetics of tissue factor messenger RNA expression during human endotoxemia: relationship with activation of coagulation RF Franco, E de Jonge, PEP Dekkers, JJ Timmerman, CA Spek, ... Blood, The Journal of the American Society of Hematology 96 (2), 554-559, 2000 | 295 | 2000 |
| Expression profiling via novel multiplex assay allows rapid assessment of gene regulation in defined signalling pathways E Eldering, CA Spek, HL Aberson, A Grummels, IA Derks, AF de Vos, ... Nucleic acids research 31 (23), e153-e153, 2003 | 256 | 2003 |
| Factor Xa: at the crossroads between coagulation and signaling in physiology and disease K Borensztajn, MP Peppelenbosch, CA Spek Trends in molecular medicine 14 (10), 429-440, 2008 | 233 | 2008 |
| Alternatively spliced tissue factor induces angiogenesis through integrin ligation YW van den Berg, LG van den Hengel, HR Myers, O Ayachi, E Jordanova, ... Proceedings of the National Academy of Sciences 106 (46), 19497-19502, 2009 | 192 | 2009 |
| Antiinflammatory effects of salmeterol after inhalation of lipopolysaccharide by healthy volunteers NA Maris, AF de Vos, MC Dessing, CA Spek, R Lutter, HM Jansen, ... American journal of respiratory and critical care medicine 172 (7), 878-884, 2005 | 172 | 2005 |
| Hedgehog signaling maintains chemoresistance in myeloid leukemic cells KCS Queiroz, RR Ruela-de-Sousa, GM Fuhler, HL Aberson, CV Ferreira, ... Oncogene 29 (48), 6314-6322, 2010 | 171 | 2010 |
| Factor Xa stimulates proinflammatory and profibrotic responses in fibroblasts via protease-activated receptor-2 activation K Borensztajn, J Stiekema, S Nijmeijer, PH Reitsma, MP Peppelenbosch, ... The American journal of pathology 172 (2), 309-320, 2008 | 156 | 2008 |
| Tissue factor and cancer metastasis: the role of intracellular and extracellular signaling pathways HH Versteeg, CA Spek, MP Peppelenbosch, DJ Richel Molecular medicine 10, 6-11, 2004 | 155 | 2004 |
| The pleiotropic effects of tissue factor: a possible role for factor VIIa-induced intracellular signalling? HH Versteeg, MP Peppelenbosch, AC Spek Thrombosis and haemostasis 86 (12), 1353-1359, 2001 | 146 | 2001 |
| Coagulation factors VIIa and Xa inhibit apoptosis and anoikis HH Versteeg, C Arnold Spek, DJ Richel, MP Peppelenbosch Oncogene 23 (2), 410-417, 2004 | 144 | 2004 |
| Genotypic variation in the promoter region of the protein C gene is associated with plasma protein C levels and thrombotic risk CA Spek, T Koster, FR Rosendaal, RM Bertina, PH Reitsma Arteriosclerosis, thrombosis, and vascular biology 15 (2), 214-218, 1995 | 141 | 1995 |
| Hedgehog: an unusual signal transducer MF Bijlsma, CA Spek, MP Peppelenbosch Bioessays 26 (4), 387-394, 2004 | 129 | 2004 |
| Sonic hedgehog induces transcription-independent cytoskeletal rearrangement and migration regulated by arachidonate metabolites MF Bijlsma, KS Borensztajn, H Roelink, MP Peppelenbosch, CA Spek Cellular signalling 19 (12), 2596-2604, 2007 | 123 | 2007 |
| Disseminated intravascular coagulation. SH Slofstra, CA Spek, H ten Cate The hematology journal: the official journal of the European Haematology …, 2003 | 118 | 2003 |
| Hypoxia induces a hedgehog response mediated by HIF‐1α MF Bijlsma, AP Groot, JP Oduro, RJ Franken, SHHF Schoenmakers, ... Journal of cellular and molecular medicine 13 (8b), 2053-2060, 2009 | 112 | 2009 |
| Activated protein C protects against myocardial ischemia/reperfusion injury via inhibition of apoptosis and inflammation STBG Loubele, CA Spek, P Leenders, R van Oerle, HL Aberson, ... Arteriosclerosis, thrombosis, and vascular biology 29 (7), 1087-1092, 2009 | 109 | 2009 |
| mTOR inhibitor treatment of pancreatic cancer in a patient with Peutz-Jeghers syndrome HJ Klümpen, KCS Queiroz, CA Spek, CJM Van Noesel, HC Brink, ... Journal of clinical oncology 29 (6), e150-e153, 2011 | 108 | 2011 |
| Additional value of procalcitonin for diagnosis of infection in patients with fever at the emergency department MD de Kruif, M Limper, H Gerritsen, CA Spek, DPM Brandjes, H ten Cate, ... Critical care medicine 38 (2), 457-463, 2010 | 106 | 2010 |