| ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysis P Towler, B Staker, SG Prasad, S Menon, J Tang, T Parsons, D Ryan, ... Journal of Biological Chemistry 279 (17), 17996-18007, 2004 | 798 | 2004 |
| Phosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T-cell receptor function JB Wardenburg, C Fu, JK Jackman, H Flotow, SE Wilkinson, DH Williams, ... Journal of Biological Chemistry 271 (33), 19641-19644, 1996 | 496 | 1996 |
| Iminosugars past, present and future: medicines for tomorrow G Horne, FX Wilson, J Tinsley, DH Williams, R Storer Drug discovery today 16 (3-4), 107-118, 2011 | 394 | 2011 |
| Structure of the catalytic domain of human fibroblast collagenase complexed with an inhibitor N Borkakoti, FK Winkler, DH Williams, A D'arcy, MJ Broadhurst, RA Brown, ... Nature Structural Biology 1 (2), 106-110, 1994 | 270 | 1994 |
| Structure of the protein tyrosine kinase domain of C-terminal Src kinase (CSK) in complex with staurosporine MBAC Lamers, AA Antson, RE Hubbard, RK Scott, DH Williams Journal of molecular biology 285 (2), 713-725, 1999 | 182 | 1999 |
| Recent kinase and kinase inhibitor X-ray structures: mechanisms of inhibition and selectivity insights M Cherry, DH Williams Current medicinal chemistry 11 (6), 663-673, 2004 | 158 | 2004 |
| Drug-resistant aurora A mutants for cellular target validation of the small molecule kinase inhibitors MLN8054 and MLN8237 DA Sloane, MZ Trikic, MLH Chu, MBAC Lamers, CS Mason, I Mueller, ... ACS chemical biology 5 (6), 563-576, 2010 | 124 | 2010 |
| The preclinical pharmacology and therapeutic activity of the novel CHK1 inhibitor SAR-020106 MI Walton, PD Eve, A Hayes, M Valenti, A De Haven Brandon, G Box, ... Molecular cancer therapeutics 9 (1), 89-100, 2010 | 102 | 2010 |
| Discovery and exploitation of inhibitor-resistant aurora and polo kinase mutants for the analysis of mitotic networks PJ Scutt, MLH Chu, DA Sloane, M Cherry, CR Bignell, DH Williams, ... Journal of Biological Chemistry 284 (23), 15880-15893, 2009 | 80 | 2009 |
| Structure-guided evolution of potent and selective CHK1 inhibitors through scaffold morphing JC Reader, TP Matthews, S Klair, KMJ Cheung, J Scanlon, N Proisy, ... Journal of medicinal chemistry 54 (24), 8328-8342, 2011 | 76 | 2011 |
| Ro 09-2210 exhibits potent anti-proliferative effects on activated T cells by selectively blocking MKK activity DH Williams, SE Wilkinson, T Purton, A Lamont, H Flotow, EJ Murray Biochemistry 37 (26), 9579-9585, 1998 | 73 | 1998 |
| Identification of inhibitors of checkpoint kinase 1 through template screening TP Matthews, S Klair, S Burns, K Boxall, M Cherry, M Fisher, IM Westwood, ... Journal of medicinal chemistry 52 (15), 4810-4819, 2009 | 53 | 2009 |
| Structure of a Cys25→ Ser mutant of human cathepsin S JP Turkenburg, MBAC Lamers, AM Brzozowski, LM Wright, RE Hubbard, ... Acta Crystallographica Section D: Biological Crystallography 58 (3), 451-455, 2002 | 52 | 2002 |
| The role of protein kinase C in the regulation of extracellular signal‐regulated kinase by the T cell antigen receptor M Izquierdo, SJ Leevers, DH Williams, CJ Marshall, A Weiss, D Cantrell European journal of immunology 24 (10), 2462-2468, 1994 | 48 | 1994 |
| Protein kinase C is not a downstream effector of p21ras in activated T cells DH Williams, M Woodrow, DA Cantrell, EJ Murray European journal of immunology 25 (1), 42-47, 1995 | 41 | 1995 |
| Latest developments in crystallography and structure-based design of protein kinase inhibitors as drug candidates DH Williams, T Mitchell Current opinion in pharmacology 2 (5), 567-573, 2002 | 40 | 2002 |
| Biophysical and X-ray Crystallographic Analysis of Mps1 Kinase Inhibitor Complexes, MLH Chu, Z Lang, LMG Chavas, J Neres, OS Fedorova, L Tabernero, ... Biochemistry 49 (8), 1689-1701, 2010 | 37 | 2010 |
| Aurothioglucose inhibits induced NF-kB and AP-1 activity by acting as an IL-1 functional antagonist DH Williams, LJ Jeffery, EJ Murray Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1180 (1), 9-14, 1992 | 36 | 1992 |
| A new regulatory switch in a JAK protein kinase V Tsui, P Gibbons, M Ultsch, K Mortara, C Chang, W Blair, R Pulk, ... Proteins: Structure, Function, and Bioinformatics 79 (2), 393-401, 2011 | 33 | 2011 |
| Human MAFA has alternatively spliced variants MBAC Lamers, AG Lamont, DH Williams Biochimica et Biophysica Acta (BBA)-Gene Structure and Expression 1399 (2-3 …, 1998 | 21 | 1998 |
Roderick HubbardUniversity of York and Vernalis (R&D) LtdBestätigte E-Mail-Adresse bei york.ac.uk
