| Penetration of dexamethasone into brain glucocorticoid targets is enhanced in mdr1A P-glycoprotein knockout mice OC Meijer, ECM De Lange, DD Breimer, AG De Boer, JO Workel, ... Endocrinology 139 (4), 1789-1793, 1998 | 465 | 1998 |
| Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier J Wijnholds, ECM de Lange, GL Scheffer, DJ van den Berg, CAAM Mol, ... The Journal of clinical investigation 105 (3), 279-285, 2000 | 464 | 2000 |
| Age-associated physiological and pathological changes at the blood–brain barrier: A review F Erdő, L Denes, E de Lange Journal of Cerebral Blood Flow & Metabolism 37 (1), 4-24, 2017 | 453 | 2017 |
| Multidrug resistance P-glycoprotein hampers the access of cortisol but not of corticosterone to mouse and human brain AM Karssen, OC Meijer, ICJ Van Der Sandt, PJ Lucassen, ECM De Lange, ... Endocrinology 142 (6), 2686-2694, 2001 | 345 | 2001 |
| Mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) modeling in translational drug research M Danhof, ECM De Lange, OE Della Pasqua, BA Ploeger, RA Voskuyl Trends in pharmacological sciences 29 (4), 186-191, 2008 | 337 | 2008 |
| Methodological issues in microdialysis sampling for pharmacokinetic studies ECM de Lange, AG De Boer, DD Breimer Advanced drug delivery reviews 45 (2-3), 125-148, 2000 | 328 | 2000 |
| Mechanism-based pharmacokinetic-pharmacodynamic modeling: biophase distribution, receptor theory, and dynamical systems analysis M Danhof, J de Jongh, ECM De Lange, O Della Pasqua, BA Ploeger, ... Annu. Rev. Pharmacol. Toxicol. 47 (1), 357-400, 2007 | 309 | 2007 |
| Methodological considerations of intracerebral microdialysis in pharmacokinetic studies on drug transport across the blood–brain barrier ECM de Lange, M Danhof, AG de Boer, DD Breimer Brain research reviews 25 (1), 27-49, 1997 | 280 | 1997 |
| Considerations in the use of cerebrospinal fluid pharmacokinetics to predict brain target concentrations in the clinical setting: implications of the barriers between blood and … ECM de Lange, M Danhof Clinical pharmacokinetics 41, 691-703, 2002 | 278 | 2002 |
| The role of P‐glycoprotein in blood‐brain barrier transport of morphine: transcortical microdialysis studies in mdr1a (−/−) and mdr1a (+/+) mice R Xie, M Hammarlund‐Udenaes, AG De Boer, ECM De Lange British journal of pharmacology 128 (3), 563-568, 1999 | 250 | 1999 |
| Potential role of ABC transporters as a detoxification system at the blood–CSF barrier ECM de Lange Advanced drug delivery reviews 56 (12), 1793-1809, 2004 | 224 | 2004 |
| Imaging techniques in Alzheimer’s disease: a review of applications in early diagnosis and longitudinal monitoring WM van Oostveen, ECM de Lange International journal of molecular sciences 22 (4), 2110, 2021 | 219 | 2021 |
| Drug Equilibration Across the Blood—Brain Barrier-Pharmacokinetic Considerations Based on the Microdialysis Method M Hammarlund-Udenaes, LK Paalzow, ECM de Lange Pharmaceutical research 14, 128-134, 1997 | 207 | 1997 |
| Kinetics for Drug Discovery: an industry-driven effort to target drug residence time DA Schuetz, WEA de Witte, YC Wong, B Knasmueller, L Richter, DB Kokh, ... Drug discovery today 22 (6), 896-911, 2017 | 204 | 2017 |
| Glutathione PEGylated liposomes: pharmacokinetics and delivery of cargo across the blood–brain barrier in rats J Rip, L Chen, R Hartman, A van den Heuvel, A Reijerkerk, J van Kregten, ... Journal of drug targeting 22 (5), 460-467, 2014 | 193 | 2014 |
| P-glycoprotein-mediated efflux of antiepileptic drugs: preliminary studies in mdr1a knockout mice GJ Sills, P Kwan, E Butler, ECM de Lange, DJ van den Berg, MJ Brodie Epilepsy & Behavior 3 (5), 427-432, 2002 | 145 | 2002 |
| Physiologically based pharmacokinetic modeling to investigate regional brain distribution kinetics in rats J Westerhout, B Ploeger, J Smeets, M Danhof, ECM de Lange The AAPS journal 14, 543-553, 2012 | 144 | 2012 |
| Critical factors of intracerebral microdialysis as a technique to determined the pharmacokinetics of drugs in rat brain ECM de Lange, M Danhof, AG de Boer, DD Breimer Brain research 666 (1), 1-8, 1994 | 138 | 1994 |
| Utility of CSF in translational neuroscience ECM de Lange Journal of pharmacokinetics and pharmacodynamics 40, 315-326, 2013 | 133 | 2013 |
| The mastermind approach to CNS drug therapy: translational prediction of human brain distribution, target site kinetics, and therapeutic effects ECM de Lange Fluids and Barriers of the CNS 10, 1-16, 2013 | 130 | 2013 |
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