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Ben Kleinstiver
Ben Kleinstiver
Associate Professor, Mass General Hospital; Harvard Medical School; Kayden-Lambert MGH Scholar
Bestätigte E-Mail-Adresse bei mgh.harvard.edu - Startseite
Titel
Zitiert von
Zitiert von
Jahr
High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects
BP Kleinstiver, V Pattanayak, MS Prew, SQ Tsai, NT Nguyen, Z Zheng, ...
Nature 529 (7587), 490-495, 2016
30172016
Engineered CRISPR-Cas9 nucleases with altered PAM specificities
BP Kleinstiver, MS Prew, SQ Tsai, VV Topkar, NT Nguyen, Z Zheng, ...
Nature 523 (7561), 481-485, 2015
19842015
Enhanced proofreading governs CRISPR–Cas9 targeting accuracy
JS Chen, YS Dagdas, BP Kleinstiver, MM Welch, AA Sousa, ...
Nature 550 (7676), 407-410, 2017
12222017
Unconstrained genome targeting with near-PAMless engineered CRISPR-Cas9 variants
RT Walton, KA Christie, MN Whittaker, BP Kleinstiver
Science 368 (6488), 290-296, 2020
10602020
Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition
BP Kleinstiver, MS Prew, SQ Tsai, NT Nguyen, VV Topkar, Z Zheng, ...
Nature Biotechnology, 2015
7552015
Genome-wide specificities of CRISPR-Cas Cpf1 nucleases in human cells
BP Kleinstiver, SQ Tsai, MS Prew, NT Nguyen, MM Welch, JM Lopez, ...
Nature Biotechnology 34 (8), 869-874, 2016
7512016
Engineered CRISPR–Cas12a variants with increased activities and improved targeting ranges for gene, epigenetic and base editing
BP Kleinstiver, AA Sousa, RT Walton, YE Tak, JY Hsu, K Clement, ...
Nature biotechnology 37 (3), 276-282, 2019
6432019
High levels of AAV vector integration into CRISPR-induced DNA breaks
KS Hanlon, BP Kleinstiver, SP Garcia, MP Zaborowski, A Volak, SE Spirig, ...
Nature communications 10 (1), 4439, 2019
3912019
Prediction of off-target activities for the end-to-end design of CRISPR guide RNAs
J Listgarten, M Weinstein, BP Kleinstiver, AA Sousa, JK Joung, J Crawford, ...
Nature biomedical engineering 2 (1), 38-47, 2018
3132018
Astrocytic interleukin-3 programs microglia and limits Alzheimer’s disease
CS McAlpine, J Park, A Griciuc, E Kim, SH Choi, Y Iwamoto, MG Kiss, ...
Nature 595 (7869), 701-706, 2021
2572021
Discovery of widespread type I and type V CRISPR-Cas inhibitors
ND Marino, JY Zhang, AL Borges, AA Sousa, LM Leon, BJ Rauch, ...
Science 362 (6411), 240-242, 2018
2572018
Activities and specificities of CRISPR/Cas9 and Cas12a nucleases for targeted mutagenesis in maize
K Lee, Y Zhang, BP Kleinstiver, JA Guo, MJ Aryee, J Miller, A Malzahn, ...
Plant biotechnology journal 17 (2), 362-372, 2019
2402019
Inducible and multiplex gene regulation using CRISPR–Cpf1-based transcription factors
YE Tak, BP Kleinstiver, JK Nuñez, JY Hsu, JE Horng, J Gong, ...
Nature methods 14 (12), 1163-1166, 2017
2212017
Allele-specific gene editing prevents deafness in a model of dominant progressive hearing loss
B György, C Nist-Lund, B Pan, Y Asai, KD Karavitaki, BP Kleinstiver, ...
Nature medicine 25 (7), 1123-1130, 2019
2032019
CRISPR/Cas9 Mediated Disruption of the SwedishAPP Allele as a Therapeutic Approach for Early-Onset Alzheimer’s Disease
B György, C Lööv, MP Zaborowski, S Takeda, BP Kleinstiver, C Commins, ...
Molecular Therapy-Nucleic Acids 11, 429-440, 2018
1882018
Isocitrate dehydrogenase mutations confer dasatinib hypersensitivity and SRC dependence in intrahepatic cholangiocarcinoma
SK Saha, JD Gordan, BP Kleinstiver, P Vu, MS Najem, JC Yeo, L Shi, ...
Cancer discovery 6 (7), 727-739, 2016
1682016
Optimization of AsCas12a for combinatorial genetic screens in human cells
PC DeWeirdt, KR Sanson, AK Sangree, M Hegde, RE Hanna, MN Feeley, ...
Nature biotechnology 39 (1), 94-104, 2021
1532021
Allele-Specific CRISPR-Cas9 Genome Editing of the Single-Base P23H Mutation for Rhodopsin-Associated Dominant Retinitis Pigmentosa
P Li, BP Kleinstiver, MY Leon, MS Prew, D Navarro-Gomez, ...
The CRISPR Journal 1 (1), 55-64, 2018
1322018
Hypoxia drives transient site-specific copy gain and drug-resistant gene expression
JC Black, E Atabakhsh, J Kim, KM Biette, C Van Rechem, B Ladd, ...
Genes & development 29 (10), 1018-1031, 2015
1082015
Engineered CRISPR-Cas9 nucleases
JK Joung, B Kleinstiver, V Pattanayak
US Patent 9,512,446, 2016
1062016
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