| The X-ray crystal structure of full-length human plasminogen RHP Law, T Caradoc-Davies, N Cowieson, AJ Horvath, AJ Quek, ... Cell reports 1 (3), 185-190, 2012 | 260 | 2012 |
| Embryogenesis and adult life in the absence of intrinsic apoptosis effectors BAX, BAK, and BOK FFS Ke, HK Vanyai, AD Cowan, ARD Delbridge, L Whitehead, S Grabow, ... Cell 173 (5), 1217-1230. e17, 2018 | 207 | 2018 |
| Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis EJ Petrie, JJ Sandow, AV Jacobsen, BJ Smith, MDW Griffin, IS Lucet, ... Nature communications 9 (1), 2422, 2018 | 195 | 2018 |
| Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity S Imaide, KM Riching, N Makukhin, V Vetma, C Whitworth, SJ Hughes, ... Nature chemical biology 17 (11), 1157-1167, 2021 | 173 | 2021 |
| Driving E3 ligase substrate specificity for targeted protein degradation: lessons from nature and the laboratory AD Cowan, A Ciulli Annual review of biochemistry 91 (1), 295-319, 2022 | 78 | 2022 |
| Targeted protein degradation via intramolecular bivalent glues O Hsia, M Hinterndorfer, AD Cowan, K Iso, T Ishida, R Sundaramoorthy, ... Nature 627 (8002), 204-211, 2024 | 70 | 2024 |
| Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis Y Meng, KA Davies, C Fitzgibbon, SN Young, SE Garnish, CR Horne, ... Nature Communications 12 (1), 6783, 2021 | 68 | 2021 |
| Conversion of Bim-BH3 from activator to inhibitor of Bak through structure-based design JM Brouwer, P Lan, AD Cowan, JP Bernardini, RW Birkinshaw, ... Molecular cell 68 (4), 659-672. e9, 2017 | 66 | 2017 |
| BAK core dimers bind lipids and can be bridged by them AD Cowan, NA Smith, JJ Sandow, EA Kapp, YH Rustam, JM Murphy, ... Nature structural & molecular biology 27 (11), 1024-1031, 2020 | 62 | 2020 |
| Potent inhibition of necroptosis by simultaneously targeting multiple effectors of the pathway CL Pierotti, MC Tanzer, AV Jacobsen, JM Hildebrand, JM Garnier, ... ACS Chemical Biology 15 (10), 2702-2713, 2020 | 26 | 2020 |
| Sequence differences between BAX and BAK core domains manifest as differences in their interactions with lipids MS Miller, AD Cowan, JM Brouwer, ST Smyth, L Peng, AZ Wardak, ... The FEBS Journal 291 (11), 2335-2353, 2024 | 6 | 2024 |
| The Bak core dimer focuses triacylglycerides in the membrane NA Smith, AZ Wardak, AD Cowan, PM Colman, PE Czabotar, BJ Smith Biophysical Journal 121 (3), 347-360, 2022 | 3 | 2022 |
| Structures of bak with lipids: implications for pore formation P Czabotar, A Cowan, P Colman Acta Cryst A 73, C104, 2017 | 1 | 2017 |
| Dissecting the RIPK3/MLKL necroptotic molecular switch K Davies, Y Meng, C Fitzgibbon, S Young, S Garnish, C Horne, C Luo, ... ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES 79, C842-C842, 2023 | | 2023 |
| Sulphonamide compounds JMD Garnier, M Brzozowski, JT Feutrill, GL Lessene, C Gardner, ... US Patent App. 18/011,410, 2023 | | 2023 |
| Amido compounds JMD Garnier, M Brzozowski, JT Feutrill, GL Lessene, C Gardner, ... US Patent App. 18/011,408, 2023 | | 2023 |
| Structural and Functional Characterisation of Bok, a Pro-apoptotic Bcl-2 Effector Protein AD Cowan, PM Colman, PE Czabotar Acta Crystallographica Section A: Foundations and Advances 72, s237-s237, 2016 | | 2016 |
