Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells ODK Maddocks, CR Berkers, SM Mason, L Zheng, K Blyth, E Gottlieb, ... Nature 493 (7433), 542-546, 2013 | 1031 | 2013 |
Serine is a natural ligand and allosteric activator of pyruvate kinase M2 B Chaneton, P Hillmann, L Zheng, ACL Martin, ODK Maddocks, ... Nature 491 (7424), 458-462, 2012 | 688 | 2012 |
A roadmap for interpreting 13C metabolite labeling patterns from cells JM Buescher, MR Antoniewicz, LG Boros, SC Burgess, H Brunengraber, ... Current opinion in biotechnology 34, 189-201, 2015 | 664 | 2015 |
Serine, but not glycine, supports one-carbon metabolism and proliferation of cancer cells CF Labuschagne, NJF Van Den Broek, GM Mackay, KH Vousden, ... Cell reports 7 (4), 1248-1258, 2014 | 604 | 2014 |
Modulating the therapeutic response of tumours to dietary serine and glycine starvation ODK Maddocks, D Athineos, EC Cheung, P Lee, T Zhang, ... Nature 544 (7650), 372-376, 2017 | 578 | 2017 |
Metabolic regulation by p53 family members CR Berkers, ODK Maddocks, EC Cheung, I Mor, KH Vousden Cell metabolism 18 (5), 617-633, 2013 | 506 | 2013 |
One-carbon metabolism in cancer AC Newman, ODK Maddocks British journal of cancer 116 (12), 1499-1504, 2017 | 471 | 2017 |
Serine metabolism supports the methionine cycle and DNA/RNA methylation through de novo ATP synthesis in cancer cells ODK Maddocks, CF Labuschagne, PD Adams, KH Vousden Molecular cell 61 (2), 210-221, 2016 | 445 | 2016 |
Metabolic regulation by p53 ODK Maddocks, KH Vousden Journal of molecular medicine 89, 237-245, 2011 | 398 | 2011 |
Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy M Tajan, M Hennequart, EC Cheung, F Zani, AK Hock, N Legrave, ... Nature communications 12 (1), 366, 2021 | 223 | 2021 |
Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity B Carroll, D Maetzel, ODK Maddocks, G Otten, M Ratcliff, GR Smith, ... Elife 5, e11058, 2016 | 219 | 2016 |
Attaching and effacing Escherichia coli downregulate DNA mismatch repair protein in vitro and are associated with colorectal adenocarcinomas in humans ODK Maddocks, AJ Short, MS Donnenberg, S Bader, DJ Harrison PloS one 4 (5), e5517, 2009 | 171 | 2009 |
Serine one-carbon catabolism with formate overflow J Meiser, S Tumanov, O Maddocks, CF Labuschagne, D Athineos, ... Science advances 2 (10), e1601273, 2016 | 168 | 2016 |
Serine and functional metabolites in cancer AC Newman, ODK Maddocks Trends in cell biology 27 (9), 645-657, 2017 | 165 | 2017 |
Persistent mTORC1 signaling in cell senescence results from defects in amino acid and growth factor sensing B Carroll, G Nelson, Y Rabanal-Ruiz, O Kucheryavenko, ... Journal of Cell Biology 216 (7), 1949-1957, 2017 | 158 | 2017 |
The creatine–phosphagen system is mechanoresponsive in pancreatic adenocarcinoma and fuels invasion and metastasis V Papalazarou, T Zhang, NR Paul, A Juin, M Cantini, ODK Maddocks, ... Nature metabolism 2 (1), 62-80, 2020 | 124 | 2020 |
Metabolic cross-feeding in imbalanced diets allows gut microbes to improve reproduction and alter host behaviour SF Henriques, DB Dhakan, L Serra, AP Francisco, Z Carvalho-Santos, ... Nature communications 11 (1), 4236, 2020 | 120 | 2020 |
A neuronal relay mediates a nutrient responsive gut/fat body axis regulating energy homeostasis in adult Drosophila A Scopelliti, C Bauer, Y Yu, T Zhang, B Kruspig, DJ Murphy, M Vidal, ... Cell metabolism 29 (2), 269-284. e10, 2019 | 98 | 2019 |
An Escherichia coli effector protein promotes host mutation via depletion of DNA mismatch repair proteins ODK Maddocks, KM Scanlon, MS Donnenberg MBio 4 (3), 10.1128/mbio. 00152-13, 2013 | 97 | 2013 |
Immune-regulated IDO1-dependent tryptophan metabolism is source of one-carbon units for pancreatic cancer and stellate cells AC Newman, M Falcone, AH Uribe, T Zhang, D Athineos, M Pietzke, ... Molecular Cell 81 (11), 2290-2302. e7, 2021 | 78 | 2021 |