| Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods C Wu, Y Liu, Y Yang, P Zhang, W Zhong, Y Wang, Q Wang, Y Xu, M Li, ... Acta Pharmaceutica Sinica B 10 (5), 766-788, 2020 | 2646 | 2020 |
| Structures of the Omicron spike trimer with ACE2 and an anti-Omicron antibody W Yin, Y Xu, P Xu, X Cao, C Wu, C Gu, X He, X Wang, S Huang, Q Yuan, ... Science 375 (6584), 1048-1053, 2022 | 267 | 2022 |
| Furin: a potential therapeutic target for COVID-19 C Wu, M Zheng, Y Yang, X Gu, K Yang, M Li, Y Liu, Q Zhang, P Zhang, ... Iscience 23 (10), 2020 | 177 | 2020 |
| Rational design and synthesis of novel dual PROTACs for simultaneous degradation of EGFR and PARP M Zheng, J Huo, X Gu, Y Wang, C Wu, Q Zhang, W Wang, Y Liu, Y Liu, ... Journal of Medicinal Chemistry 64 (11), 7839-7852, 2021 | 141 | 2021 |
| Structure genomics of SARS-CoV-2 and its Omicron variant: drug design templates for COVID-19 C Wu, W Yin, Y Jiang, HE Xu Acta Pharmacologica Sinica 43 (12), 3021-3033, 2022 | 120 | 2022 |
| Structural and biochemical mechanism for increased infectivity and immune evasion of Omicron BA. 2 variant compared to BA. 1 and their possible mouse origins Y Xu, C Wu, X Cao, C Gu, H Liu, M Jiang, X Wang, Q Yuan, K Wu, J Liu, ... Cell research 32 (7), 609-620, 2022 | 79 | 2022 |
| Novel selective hexokinase 2 inhibitor Benitrobenrazide blocks cancer cells growth by targeting glycolysis M Zheng, C Wu, K Yang, Y Yang, Y Liu, S Gao, Q Wang, C Li, L Chen, ... Pharmacological research 164, 105367, 2021 | 73 | 2021 |
| New natural inhibitors of hexokinase 2 (HK2): Steroids from Ganoderma sinense F Bao, K Yang, C Wu, S Gao, P Wang, L Chen, H Li Fitoterapia 125, 123-129, 2018 | 64 | 2018 |
| Novel PROTACs for degradation of SHP2 protein M Zheng, Y Liu, C Wu, K Yang, Q Wang, Y Zhou, L Chen, H Li Bioorganic Chemistry 110, 104788, 2021 | 59 | 2021 |
| Glutaminase inhibitors: a patent review CR Wu, LX Chen, S Jin, H Li Expert Opinion on Therapeutic Patents 28 (11), 823-835, 2018 | 42 | 2018 |
| Structure based discovery of novel hexokinase 2 inhibitors Y Liu, M Li, Y Zhang, C Wu, K Yang, S Gao, M Zheng, X Li, H Li, L Chen Bioorganic chemistry 96, 103609, 2020 | 31 | 2020 |
| Synthesis of novel andrographolide beckmann rearrangement derivatives and evaluation of their HK2-related anti-inflammatory activities W Wang, Y Wu, K Yang, C Wu, R Tang, H Li, L Chen European Journal of Medicinal Chemistry 173, 282-293, 2019 | 31 | 2019 |
| Physapubescin, a natural withanolide as a kidney-type glutaminase (KGA) inhibitor L Cheng, CR Wu, LH Zhu, H Li, LX Chen Bioorganic & Medicinal Chemistry Letters 27 (5), 1243-1246, 2017 | 28 | 2017 |
| 3-Phosphoglycerate dehydrogenase: a potential target for cancer treatment M Li, C Wu, Y Yang, M Zheng, S Yu, J Wang, L Chen, H Li Cellular Oncology 44, 541-556, 2021 | 27 | 2021 |
| Discovery of an orally active small-molecule tumor necrosis factor-α inhibitor W Sun, Y Wu, M Zheng, Y Yang, Y Liu, C Wu, Y Zhou, Y Zhang, L Chen, ... Journal of medicinal chemistry 63 (15), 8146-8156, 2020 | 23 | 2020 |
| A natural inhibitor of kidney-type glutaminase: a withanolide from Physalis pubescens with potent anti-tumor activity C Wu, M Zheng, S Gao, S Luan, L Cheng, L Wang, J Li, L Chen, H Li Oncotarget 8 (69), 113516, 2017 | 22 | 2017 |
| Physapubescin I from husk tomato suppresses SW1990 cancer cell growth by targeting kidney-type glutaminase KY Yang, CR Wu, MZ Zheng, RT Tang, XZ Li, LX Chen, H Li Bioorganic Chemistry 92, 103186, 2019 | 20 | 2019 |
| In silico analysis of intermediate hosts and susceptible animals of SARS-CoV-2 C Wu, M Zheng, Y Yang, M Li, Y Liu, P Zhang, Y Wang, Q Wang, Y Xu, ... | 17 | 2020 |
| Ligand-induced activation and G protein coupling of prostaglandin F2α receptor C Wu, Y Xu, Q He, D Li, J Duan, C Li, C You, H Chen, W Fan, Y Jiang, ... Nature Communications 14 (1), 2668, 2023 | 13 | 2023 |
| Structures of the Omicron spike trimer with ACE2 and an anti-Omicron antibody: mechanisms for the high infectivity, immune evasion and antibody drug discovery W Yin, Y Xu, P Xu, X Cao, C Wu, C Gu, X He, X Wang, S Huang, Q Yuan, ... bioRxiv, 2021.12. 27.474273, 2021 | 13 | 2021 |
