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Charlie Lees
Charlie Lees
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Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease
L Jostins, S Ripke, RK Weersma, RH Duerr, DP McGovern, KY Hui, ...
Nature 491 (7422), 119-124, 2012
54472012
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
A Franke, DPB McGovern, JC Barrett, K Wang, GL Radford-Smith, ...
Nature genetics 42 (12), 1118-1125, 2010
32042010
Guidelines for the management of inflammatory bowel disease in adults
C Mowat, A Cole, AL Windsor, T Ahmad, I Arnott, R Driscoll, S Mitton, ...
Gut 60 (5), 571-607, 2011
18072011
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
CA Anderson, G Boucher, CW Lees, A Franke, M D'Amato, KD Taylor, ...
Nature genetics 43 (3), 246-252, 2011
17712011
Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants
1958 Birth Cohort Controls: Jones Richard W 18 McArdle Wendy L 18 Ring Susan ...
Nature genetics 39 (11), 1329-1337, 2007
14742007
Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility
M Parkes, JC Barrett, NJ Prescott, M Tremelling, CA Anderson, SA Fisher, ...
Nature genetics 39 (7), 830-832, 2007
14452007
Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease
KM De Lange, L Moutsianas, JC Lee, CA Lamb, Y Luo, NA Kennedy, ...
Nature genetics 49 (2), 256-261, 2017
14192017
Second European evidence-based consensus on the prevention, diagnosis and management of opportunistic infections in inflammatory bowel disease
JF Rahier, F Magro, C Abreu, A Armuzzi, S Ben-Horin, Y Chowers, ...
Journal of Crohn's and Colitis 8 (6), 443-468, 2014
10542014
Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls
Nature 464 (7289), 713-720, 2010
9412010
Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study
I Cleynen, G Boucher, L Jostins, LP Schumm, S Zeissig, T Ahmad, ...
The Lancet 387 (10014), 156-167, 2016
8862016
New IBD genetics: common pathways with other diseases
CW Lees, JC Barrett, M Parkes, J Satsangi
Gut 60 (12), 1739-1753, 2011
8152011
Predictors of anti-TNF treatment failure in anti-TNF-naive patients with active luminal Crohn's disease: a prospective, multicentre, cohort study
NA Kennedy, GA Heap, HD Green, B Hamilton, C Bewshea, GJ Walker, ...
The lancet Gastroenterology & hepatology 4 (5), 341-353, 2019
6682019
Fine-mapping inflammatory bowel disease loci to single-variant resolution
H Huang, M Fang, L Jostins, M Umićević Mirkov, G Boucher, ...
Nature 547 (7662), 173-178, 2017
6662017
International IBD Genetics Consortium (IIBDGC). Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease
L Jostins, S Ripke, RK Weersma, RH Duerr, DP McGovern, KY Hui, ...
Nature 491 (7422), 119-124, 2012
6472012
Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region
Data and Analysis Group: Spencer Chris CA chris. spencer@ well. ox. ac. uk 5 ...
Nature genetics 41 (12), 1330-1334, 2009
6462009
Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease
SA Fisher, M Tremelling, CA Anderson, R Gwilliam, S Bumpstead, ...
Nature genetics 40 (6), 710-712, 2008
5622008
HLA-DQA1* 05 carriage associated with development of anti-drug antibodies to infliximab and adalimumab in patients with Crohn’s disease
A Sazonovs, NA Kennedy, L Moutsianas, GA Heap, DL Rice, M Reppell, ...
Gastroenterology 158 (1), 189-199, 2020
3682020
High-density mapping of the MHC identifies a shared role for HLA-DRB1* 01: 03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis
P Goyette, G Boucher, D Mallon, E Ellinghaus, L Jostins, H Huang, ...
Nature genetics 47 (2), 172-179, 2015
3602015
The impact of different DNA extraction kits and laboratories upon the assessment of human gut microbiota composition by 16S rRNA gene sequencing
NA Kennedy, AW Walker, SH Berry, SH Duncan, FM Farquarson, P Louis, ...
PloS one 9 (2), e88982, 2014
3552014
European Crohn’s and Colitis Organisation (ECCO)
JF Rahier, F Magro, C Abreu, A Armuzzi, S Ben-Horin, Y Chowers, ...
Second European evidence-based consensus on the prevention, diagnosis and …, 2014
3102014
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