| Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis Z Chen, LC Trotman, D Shaffer, HK Lin, ZA Dotan, M Niki, JA Koutcher, ... Nature 436 (7051), 725-730, 2005 | 2497 | 2005 |
| From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells S Yeh, HK Lin, HY Kang, TH Thin, MF Lin, C Chang Proceedings of the National Academy of Sciences 96 (10), 5458-5463, 1999 | 737 | 1999 |
| The mechanisms of PML-nuclear body formation TH Shen, HK Lin, PP Scaglioni, TM Yung, PP Pandolfi Molecular cell 24 (3), 331-339, 2006 | 684 | 2006 |
| The E3 ligase TRAF6 regulates Akt ubiquitination and activation WL Yang, J Wang, CH Chan, SW Lee, AD Campos, B Lamothe, L Hur, ... Science 325 (5944), 1134-1138, 2009 | 679 | 2009 |
| Phosphorylation‐dependent ubiquitylation and degradation of androgen receptor by Akt require Mdm2 E3 ligase HK Lin, L Wang, YC Hu, S Altuwaijri, C Chang The EMBO journal, 2002 | 525 | 2002 |
| Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor HK Lin, S Yeh, HY Kang, C Chang Proceedings of the National Academy of Sciences 98 (13), 7200-7205, 2001 | 510 | 2001 |
| Circular RNAs in cancer: novel insights into origins, properties, functions and implications J Li, J Yang, P Zhou, Y Le, C Zhou, S Wang, D Xu, HK Lin, Z Gong American journal of cancer research 5 (2), 472, 2015 | 491 | 2015 |
| Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence HK Lin, Z Chen, G Wang, C Nardella, SW Lee, CH Chan, WL Yang, ... Nature 464 (7287), 374-379, 2010 | 481 | 2010 |
| Lactate is a natural suppressor of RLR signaling by targeting MAVS W Zhang, G Wang, ZG Xu, H Tu, F Hu, J Dai, Y Chang, Y Chen, Y Lu, ... Cell 178 (1), 176-189. e15, 2019 | 477 | 2019 |
| LIFR is a breast cancer metastasis suppressor upstream of the Hippo-YAP pathway and a prognostic marker D Chen, Y Sun, Y Wei, P Zhang, AH Rezaeian, J Teruya-Feldstein, ... Nature medicine 18 (10), 1511-1517, 2012 | 455 | 2012 |
| PML regulates apoptosis at endoplasmic reticulum by modulating calcium release C Giorgi, K Ito, HK Lin, C Santangelo, MR Wieckowski, M Lebiedzinska, ... Science 330 (6008), 1247-1251, 2010 | 453 | 2010 |
| The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis CH Chan, CF Li, WL Yang, Y Gao, SW Lee, Z Feng, HY Huang, KKC Tsai, ... Cell 149 (5), 1098-1111, 2012 | 443 | 2012 |
| Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression CH Chan, JK Morrow, CF Li, Y Gao, G Jin, A Moten, LJ Stagg, JE Ladbury, ... Cell 154 (3), 556-568, 2013 | 415 | 2013 |
| Cytoplasmic PML function in TGF-β signalling HK Lin, S Bergmann, PP Pandolfi Nature 431 (7005), 205-211, 2004 | 407 | 2004 |
| LncRNA NBR2 engages a metabolic checkpoint by regulating AMPK under energy stress X Liu, ZD Xiao, L Han, J Zhang, SW Lee, W Wang, H Lee, L Zhuang, ... Nature cell biology 18 (4), 431-442, 2016 | 291 | 2016 |
| Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB HK Lin, G Wang, Z Chen, J Teruya-Feldstein, Y Liu, CH Chan, WL Yang, ... Nature cell biology 11 (4), 420-432, 2009 | 282 | 2009 |
| UTX and MLL4 coordinately regulate transcriptional programs for cell proliferation and invasiveness in breast cancer cells JH Kim, A Sharma, SS Dhar, SH Lee, B Gu, CH Chan, HK Lin, MG Lee Cancer research 74 (6), 1705-1717, 2014 | 258 | 2014 |
| Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradation F Wang, CH Chan, K Chen, X Guan, HK Lin, Q Tong Oncogene 31 (12), 1546-1557, 2012 | 248 | 2012 |
| Suppression versus induction of androgen receptor functions by the phosphatidylinositol 3-kinase/Akt pathway in prostate cancer LNCaP cells with different passage numbers HK Lin, YC Hu, L Yang, S Altuwaijri, YT Chen, HY Kang, C Chang Journal of Biological Chemistry 278 (51), 50902-50907, 2003 | 243 | 2003 |
| Deciphering the transcriptional complex critical for RhoA gene expression and cancer metastasis CH Chan, SW Lee, CF Li, J Wang, WL Yang, CY Wu, J Wu, KI Nakayama, ... Nature cell biology 12 (5), 457-467, 2010 | 242 | 2010 |
