| New azepino [4, 3-b] indole derivatives as nanomolar selective inhibitors of human butyrylcholinesterase showing protective effects against NMDA-induced neurotoxicity M De Candia, G Zaetta, N Denora, D Tricarico, M Majellaro, S Cellamare, ... European journal of medicinal chemistry 125, 288-298, 2017 | 55 | 2017 |
| Structure-based design of potent and selective ligands at the four adenosine receptors W Jespers, A Oliveira, R Prieto-Díaz, M Majellaro, J Åqvist, E Sotelo, ... Molecules 22 (11), 1945, 2017 | 42 | 2017 |
| X‐Ray Crystallography and Free Energy Calculations Reveal the Binding Mechanism of A2A Adenosine Receptor Antagonists W Jespers, G Verdon, J Azuaje, M Majellaro, H Keränen, X García‐Mera, ... Angewandte Chemie International Edition 59 (38), 16536-16543, 2020 | 31 | 2020 |
| 3,4-Dihydropyrimidin-2(1H)-ones as Antagonists of the Human A2B Adenosine Receptor: Optimization, Structure–Activity Relationship Studies, and … M Majellaro, W Jespers, A Crespo, MJ Núñez, S Novio, J Azuaje, ... Journal of Medicinal Chemistry 64 (1), 458-480, 2020 | 30 | 2020 |
| Nitrogen-Walk Approach to Explore Bioisosteric Replacements in a Series of Potent A2B Adenosine Receptor Antagonists A Mallo-Abreu, R Prieto-Díaz, W Jespers, J Azuaje, M Majellaro, ... Journal of Medicinal Chemistry 63 (14), 7721-7739, 2020 | 27 | 2020 |
| Similarities and differences upon binding of naturally occurring Δ9-tetrahydrocannabinol-derivatives to cannabinoid CB1 and CB2 receptors I Raïch, R Rivas-Santisteban, A Lillo, J Lillo, I Reyes-Resina, X Nadal, ... Pharmacological Research 174, 105970, 2021 | 24 | 2021 |
| Trifluorinated Pyrimidine-Based A2B Antagonists: Optimization and Evidence of Stereospecific Recognition A Mallo-Abreu, M Majellaro, W Jespers, J Azuaje, O Caamano, ... Journal of Medicinal Chemistry 62 (20), 9315-9330, 2019 | 18 | 2019 |
| Effect of Nitrogen Atom Substitution in A3 Adenosine Receptor Binding: N-(4,6-Diarylpyridin-2-yl)acetamides as Potent and Selective Antagonists J Azuaje, W Jespers, V Yaziji, A Mallo, M Majellaro, O Caamano, MI Loza, ... Journal of Medicinal Chemistry 60 (17), 7502-7511, 2017 | 18 | 2017 |
| A2B adenosine receptor antagonists rescue lymphocyte activity in adenosine-producing patient-derived cancer models AHM Tay, R Prieto-Díaz, S Neo, L Tong, X Chen, V Carannante, B Önfelt, ... Journal for Immunotherapy of Cancer 10 (5), 2022 | 16 | 2022 |
| Identification of V6.51L as a selectivity hotspot in stereoselective A2B adenosine receptor antagonist recognition X Wang, W Jespers, R Prieto-Díaz, M Majellaro, AP IJzerman, ... Scientific Reports 11 (1), 14171, 2021 | 16 | 2021 |
| Novel antiproliferative biphenyl nicotinamide: NMR metabolomic study of its effect on the MCF-7 cell in comparison with cisplatin and vinblastine L Del Coco, M Majellaro, A Boccarelli, S Cellamare, CD Altomare, ... Molecules 25 (15), 3502, 2020 | 15 | 2020 |
| Catalytic performance of a metal-free graphene oxide-Al2O3 composite assembled by 3D printing J Azuaje, A Rama, A Mallo-Abreu, MG Boado, M Majellaro, CR Tubío, ... Journal of the European Ceramic Society 41 (2), 1399-1406, 2021 | 14 | 2021 |
| Exploring the Effect of Halogenation in a Series of Potent and Selective A2B Adenosine Receptor Antagonists R Prieto-Díaz, M González-Gómez, H Fojo-Carballo, J Azuaje, ... Journal of Medicinal Chemistry 66 (1), 890-912, 2022 | 13 | 2022 |
| Exploring the influence of the substituent at position 4 in a series of 3,4-dihydropyrimidin-2(1H)-one A2B adenosine receptor antagonists A Crespo, A El Maatougui, J Azuaje, L Escalante, M Majellaro, MI Loza, ... Chemistry of Heterocyclic Compounds 53, 316-321, 2017 | 9 | 2017 |
| Optimization of 2-Amino-4,6-diarylpyrimidine-5-carbonitriles as Potent and Selective A1 Antagonists C Val, C Rodríguez-García, R Prieto-Díaz, A Crespo, J Azuaje, ... Journal of Medicinal Chemistry 65 (3), 2091-2106, 2022 | 7 | 2022 |
| Investigating structural requirements for the antiproliferative activity of biphenyl nicotinamides M Majellaro, A Stefanachi, P Tardia, C Vicenti, A Boccarelli, A Pannunzio, ... ChemMedChem 12 (16), 1380-1389, 2017 | 7 | 2017 |
| Identification of A2BAR as a potential target in colorectal cancer using novel fluorescent GPCR ligands J Barbazán, M Majellaro, AL Martínez, JM Brea, E Sotelo, M Abal Biomedicine & Pharmacotherapy 153, 113408, 2022 | 6 | 2022 |
| Potent and Subtype-Selective Dopamine D2 Receptor Biased Partial Agonists Discovered via an Ugi-Based Approach A Mallo-Abreu, I Reyes-Resina, J Azuaje, R Franco, A García-Rey, ... Journal of Medicinal Chemistry 64 (12), 8710-8726, 2021 | 6 | 2021 |
| Pharmacological insights emerging from the characterization of a large collection of synthetic cannabinoid receptor agonists designer drugs C Gioé-Gallo, S Ortigueira, J Brea, I Raïch, J Azuaje, MR Paleo, ... Biomedicine & Pharmacotherapy 164, 114934, 2023 | 5 | 2023 |
| Development of Fluorescent 4-[4-(3H-Spiro[isobenzofuran-1,4′-piperidin]-1′-yl)butyl]indolyl Derivatives as High-Affinity Probes to Enable the Study of σ … FS Abatematteo, M Majellaro, B Montsch, R Prieto-Díaz, M Niso, ... Journal of Medicinal Chemistry 66 (6), 3798-3817, 2023 | 4 | 2023 |