| Direct conversion of fibroblasts into functional astrocytes by defined transcription factors M Caiazzo, S Giannelli, P Valente, G Lignani, A Carissimo, A Sessa, ... Stem cell reports 4 (1), 25-36, 2015 | 258 | 2015 |
| dCas9-based Scn1a gene activation restores inhibitory interneuron excitability and attenuates seizures in Dravet syndrome mice G Colasante, G Lignani, S Brusco, C Di Berardino, J Carpenter, ... Molecular Therapy 28 (1), 235-253, 2020 | 213 | 2020 |
| Pharmacological inhibition of necroptosis protects from dopaminergic neuronal cell death in Parkinson’s disease models A Iannielli, S Bido, L Folladori, A Segnali, C Cancellieri, A Maresca, ... Cell reports 22 (8), 2066-2079, 2018 | 209 | 2018 |
| Rapid conversion of fibroblasts into functional forebrain GABAergic interneurons by direct genetic reprogramming G Colasante, G Lignani, A Rubio, L Medrihan, L Yekhlef, A Sessa, ... Cell stem cell 17 (6), 719-734, 2015 | 187 | 2015 |
| Cas9/sgRNA selective targeting of the P23H Rhodopsin mutant allele for treating retinitis pigmentosa by intravitreal AAV9.PHP.B-based delivery SG Giannelli, M Luoni, V Castoldi, L Massimino, T Cabassi, D Angeloni, ... Human molecular genetics 27 (5), 761-779, 2018 | 141 | 2018 |
| Microglia-specific overexpression of α-synuclein leads to severe dopaminergic neurodegeneration by phagocytic exhaustion and oxidative toxicity S Bido, S Muggeo, L Massimino, MJ Marzi, SG Giannelli, E Melacini, ... Nature communications 12 (1), 6237, 2021 | 138 | 2021 |
| In vivo CRISPRa decreases seizures and rescues cognitive deficits in a rodent model of epilepsy G Colasante, Y Qiu, L Massimino, C Di Berardino, JH Cornford, ... Brain 143 (3), 891-905, 2020 | 117 | 2020 |
| SETD5 regulates chromatin methylation state and preserves global transcriptional fidelity during brain development and neuronal wiring A Sessa, L Fagnocchi, G Mastrototaro, L Massimino, M Zaghi, M Indrigo, ... Neuron 104 (2), 271-289. e13, 2019 | 108 | 2019 |
| Lorlatinib treatment elicits multiple on-and off-target mechanisms of resistance in ALK-driven cancer S Redaelli, M Ceccon, M Zappa, GG Sharma, C Mastini, M Mauri, ... Cancer research 78 (24), 6866-6880, 2018 | 97 | 2018 |
| SETBP1 induces transcription of a network of development genes by acting as an epigenetic hub R Piazza, V Magistroni, S Redaelli, M Mauri, L Massimino, A Sessa, ... Nature communications 9 (1), 2192, 2018 | 97 | 2018 |
| Metagenomic analysis of intestinal mucosa revealed a specific eukaryotic gut virome signature in early-diagnosed inflammatory bowel disease F Ungaro, L Massimino, F Furfaro, V Rimoldi, L Peyrin-Biroulet, ... Gut Microbes 10 (2), 149-158, 2019 | 91 | 2019 |
| Activation of the VEGFC/VEGFR3 pathway induces tumor immune escape in colorectal cancer C Tacconi, F Ungaro, C Correale, V Arena, L Massimino, M Detmar, ... Cancer research 79 (16), 4196-4210, 2019 | 85 | 2019 |
| The gut virome in inflammatory bowel disease pathogenesis: From metagenomics to novel therapeutic approaches F Ungaro, L Massimino, S D’Alessio, S Danese United European gastroenterology journal 7 (8), 999-1007, 2019 | 72 | 2019 |
| Local insulin-like growth factor I expression is essential for Purkinje neuron survival at birth L Croci, V Barili, D Chia, L Massimino, R van Vugt, G Masserdotti, ... Cell Death & Differentiation 18 (1), 48-59, 2011 | 72 | 2011 |
| Frataxin gene editing rescues Friedreich’s ataxia pathology in dorsal root ganglia organoid-derived sensory neurons PG Mazzara, S Muggeo, M Luoni, L Massimino, M Zaghi, PTT Valverde, ... Nature Communications 11 (1), 4178, 2020 | 71 | 2020 |
| The Inflammatory Bowel Disease Transcriptome and Metatranscriptome Meta-Analysis (IBD TaMMA) framework L Massimino, LA Lamparelli, Y Houshyar, S D’Alessio, L Peyrin-Biroulet, ... Nature Computational Science 1 (10), 703-703, 2021 | 70 | 2021 |
| MFSD2A promotes endothelial generation of inflammation-resolving lipid mediators and reduces colitis in mice F Ungaro, C Tacconi, L Massimino, PA Corsetto, C Correale, P Fonteyne, ... Gastroenterology 153 (5), 1363-1377. e6, 2017 | 67 | 2017 |
| The Tbr2 molecular network controls cortical neuronal differentiation through complementary genetic and epigenetic pathways A Sessa, E Ciabatti, D Drechsel, L Massimino, G Colasante, S Giannelli, ... Cerebral cortex 27 (6), 3378-3396, 2017 | 64 | 2017 |
| Whole brain delivery of an instability-prone Mecp2 transgene improves behavioral and molecular pathological defects in mouse models of Rett syndrome M Luoni, S Giannelli, MT Indrigo, A Niro, L Massimino, A Iannielli, ... Elife 9, e52629, 2020 | 60 | 2020 |
| Scn1a gene reactivation after symptom onset rescues pathological phenotypes in a mouse model of Dravet syndrome N Valassina, S Brusco, A Salamone, L Serra, M Luoni, S Giannelli, S Bido, ... Nature communications 13 (1), 161, 2022 | 53 | 2022 |
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