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Patrick Sexton
Patrick Sexton
Bestätigte E-Mail-Adresse bei monash.edu
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Zitiert von
Zitiert von
Jahr
Functional selectivity and classical concepts of quantitative pharmacology
JD Urban, WP Clarke, M Von Zastrow, DE Nichols, B Kobilka, H Weinstein, ...
Journal of Pharmacology and Experimental Therapeutics 320 (1), 1-13, 2007
13422007
Activation and allosteric modulation of a muscarinic acetylcholine receptor
AC Kruse, AM Ring, A Manglik, J Hu, K Hu, K Eitel, H Hübner, E Pardon, ...
Nature 504 (7478), 101-106, 2013
10052013
International Union of Pharmacology. XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors
DR Poyner, PM Sexton, I Marshall, DM Smith, R Quirion, W Born, R Muff, ...
Pharmacological reviews 54 (2), 233-246, 2002
9982002
Allosteric modulation of G protein–coupled receptors
LT May, K Leach, PM Sexton, A Christopoulos
Annu. Rev. Pharmacol. Toxicol. 47 (1), 1-51, 2007
8322007
Mechanisms of signalling and biased agonism in G protein-coupled receptors
D Wootten, A Christopoulos, M Marti-Solano, MM Babu, PM Sexton
Nature reviews Molecular cell biology 19 (10), 638-653, 2018
6842018
Abundant calcitonin receptors in isolated rat osteoclasts. Biochemical and autoradiographic characterization.
GC Nicholson, JM Moseley, PM Sexton, FA Mendelsohn, TJ Martin
The Journal of clinical investigation 78 (2), 355-360, 1986
5901986
Multiple amylin receptors arise from receptor activity-modifying protein interaction with the calcitonin receptor gene product
G Christopoulos, KJ Perry, M Morfis, N Tilakaratne, Y Gao, NJ Fraser, ...
Molecular pharmacology 56 (1), 235-242, 1999
5671999
G-protein–coupled receptor Mas is a physiological antagonist of the angiotensin II type 1 receptor
E Kostenis, G Milligan, A Christopoulos, CF Sanchez-Ferrer, ...
Circulation 111 (14), 1806-1813, 2005
5532005
Emerging paradigms in GPCR allostery: implications for drug discovery
D Wootten, A Christopoulos, PM Sexton
Nature reviews Drug discovery 12 (8), 630-644, 2013
5462013
Phase-plate cryo-EM structure of a class B GPCR–G-protein complex
YL Liang, M Khoshouei, M Radjainia, Y Zhang, A Glukhova, J Tarrasch, ...
Nature 546 (7656), 118-123, 2017
5122017
Muscarinic acetylcholine receptors: novel opportunities for drug development
AC Kruse, BK Kobilka, D Gautam, PM Sexton, A Christopoulos, J Wess
Nature reviews Drug discovery 13 (7), 549-560, 2014
4752014
Structural basis for modulation of a G-protein-coupled receptor by allosteric drugs
RO Dror, HF Green, C Valant, DW Borhani, JR Valcourt, AC Pan, ...
Nature 503 (7475), 295-299, 2013
4602013
Allosteric GPCR modulators: taking advantage of permissive receptor pharmacology
K Leach, PM Sexton, A Christopoulos
Trends in pharmacological sciences 28 (8), 382-389, 2007
4022007
Crystal structures of the M1 and M4 muscarinic acetylcholine receptors
DM Thal, B Sun, D Feng, V Nawaratne, K Leach, CC Felder, MG Bures, ...
Nature 531 (7594), 335, 2016
3672016
Glucagon-like peptide-1 and its class BG protein–coupled receptors: a long march to therapeutic successes
C De Graaf, D Donnelly, D Wootten, J Lau, PM Sexton, LJ Miller, JM Ahn, ...
Pharmacological reviews 68 (4), 954-1013, 2016
3572016
Novel receptor partners and function of receptor activity-modifying proteins
A Christopoulos, G Christopoulos, M Morfis, M Udawela, M Laburthe, ...
Journal of Biological Chemistry 278 (5), 3293-3297, 2003
3572003
The role of kinetic context in apparent biased agonism at GPCRs
C Klein Herenbrink, DA Sykes, P Donthamsetti, M Canals, T Coudrat, ...
Nature communications 7 (1), 10842, 2016
3542016
Structure of the adenosine-bound human adenosine A1 receptor–Gi complex
CJ Draper-Joyce, M Khoshouei, DM Thal, YL Liang, ATN Nguyen, ...
Nature 558 (7711), 559-563, 2018
3442018
Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor–Gs complex
YL Liang, M Khoshouei, A Glukhova, SGB Furness, P Zhao, L Clydesdale, ...
Nature 555 (7694), 121-125, 2018
3232018
In vitro autoradiographic localization of amylin binding sites in rat brain
PM Sexton, G Paxinos, MA Kenney, PJ Wookey, K Beaumont
Neuroscience 62 (2), 553-567, 1994
3191994
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