| Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1 EL Mills, DG Ryan, HA Prag, D Dikovskaya, D Menon, Z Zaslona, ... Nature 556 (7699), 113-117, 2018 | 1526 | 2018 |
| Coupling Krebs cycle metabolites to signalling in immunity and cancer DG Ryan, MP Murphy, C Frezza, HA Prag, ET Chouchani, LA O’Neill, ... Nature metabolism 1 (1), 16-33, 2019 | 359 | 2019 |
| Cardiac metabolism as a driver and therapeutic target of myocardial infarction CJ Zuurbier, L Bertrand, CR Beauloye, I Andreadou, M Ruiz‐Meana, ... Journal of cellular and molecular medicine 24 (11), 5937-5954, 2020 | 155 | 2020 |
| Succinate accumulation drives ischaemia-reperfusion injury during organ transplantation JL Martin, ASH Costa, AV Gruszczyk, TE Beach, FM Allen, HA Prag, ... Nature metabolism 1 (10), 966-974, 2019 | 134 | 2019 |
| Macrophage fumarate hydratase restrains mtRNA-mediated interferon production A Hooftman, CG Peace, DG Ryan, EA Day, M Yang, AF McGettrick, M Yin, ... Nature 615 (7952), 490-498, 2023 | 119 | 2023 |
| Structural basis for a complex I mutation that blocks pathological ROS production Z Yin, N Burger, D Kula-Alwar, D Aksentijević, HR Bridges, HA Prag, ... Nature communications 12 (1), 707, 2021 | 101 | 2021 |
| Tumor necrosis factor induces pathogenic mitochondrial ROS in tuberculosis through reverse electron transport FJ Roca, LJ Whitworth, HA Prag, MP Murphy, L Ramakrishnan Science 376 (6600), eabh2841, 2022 | 93 | 2022 |
| MitoNeoD: a mitochondria-targeted superoxide probe MM Shchepinova, AG Cairns, TA Prime, A Logan, AM James, AR Hall, ... Cell chemical biology 24 (10), 1285-1298. e12, 2017 | 91 | 2017 |
| Disruption of the TCA cycle reveals an ATF4-dependent integration of redox and amino acid metabolism DG Ryan, M Yang, HA Prag, GR Blanco, E Nikitopoulou, ... Elife 10, e72593, 2021 | 89 | 2021 |
| Mechanism of succinate efflux upon reperfusion of the ischaemic heart HA Prag, AV Gruszczyk, MM Huang, TE Beach, T Young, L Tronci, ... Cardiovascular research 117 (4), 1188-1201, 2021 | 88 | 2021 |
| Targeting succinate metabolism in ischemia/reperfusion injury D Kula-Alwar, HA Prag, T Krieg Circulation 140 (24), 1968-1970, 2019 | 71 | 2019 |
| Ischemia-selective cardioprotection by malonate for ischemia/reperfusion injury HA Prag, D Aksentijevic, A Dannhorn, AV Giles, JF Mulvey, O Sauchanka, ... Circulation research 131 (6), 528-541, 2022 | 63 | 2022 |
| Mitochondrial complex I activity in microglia sustains neuroinflammation L Peruzzotti-Jametti, CM Willis, G Krzak, R Hamel, L Pirvan, RB Ionescu, ... Nature 628 (8006), 195-203, 2024 | 59 | 2024 |
| Targeting succinate dehydrogenase with malonate ester prodrugs decreases renal ischemia reperfusion injury TE Beach, HA Prag, L Pala, A Logan, MM Huang, AV Gruszczyk, ... Redox biology 36, 101640, 2020 | 56 | 2020 |
| Ester prodrugs of malonate with enhanced intracellular delivery protect against cardiac ischemia-reperfusion injury in vivo HA Prag, L Pala, D Kula-Alwar, JF Mulvey, D Luping, TE Beach, LM Booty, ... Cardiovascular Drugs and Therapy, 1-13, 2022 | 50 | 2022 |
| Mitochondrial redox and TCA cycle metabolite signaling in the heart A Vujic, ANM Koo, HA Prag, T Krieg Free Radical Biology and Medicine 166, 287-296, 2021 | 48 | 2021 |
| Selective disruption of mitochondrial thiol redox state in cells and in vivo LM Booty, JM Gawel, F Cvetko, ST Caldwell, AR Hall, JF Mulvey, ... Cell chemical biology 26 (3), 449-461. e8, 2019 | 46 | 2019 |
| Nrf2 is activated by disruption of mitochondrial thiol homeostasis but not by enhanced mitochondrial superoxide production F Cvetko, ST Caldwell, M Higgins, T Suzuki, M Yamamoto, HA Prag, ... Journal of Biological Chemistry 296, 2021 | 39 | 2021 |
| Selective delivery of dicarboxylates to mitochondria by conjugation to a lipophilic cation via a cleavable linker HA Prag, D Kula-Alwar, L Pala, ST Caldwell, TE Beach, AM James, ... Molecular pharmaceutics 17 (9), 3526-3540, 2020 | 25 | 2020 |
| Targeting succinate metabolism to decrease brain injury upon mechanical thrombectomy treatment of ischemic stroke A Mottahedin, HA Prag, A Dannhorn, R Mair, C Schmidt, M Yang, ... Redox Biology 59, 102600, 2023 | 24 | 2023 |
