| The fatty acid biosynthesis enzyme FabI plays a key role in the development of liver-stage malarial parasites M Yu, TRS Kumar, LJ Nkrumah, A Coppi, S Retzlaff, CD Li, BJ Kelly, ... Cell host & microbe 4 (6), 567-578, 2008 | 342 | 2008 |
| In silico repositioning of approved drugs for rare and neglected diseases S Ekins, AJ Williams, MD Krasowski, JS Freundlich Drug discovery today 16 (7-8), 298-310, 2011 | 334 | 2011 |
| Drugs versus bugs: in pursuit of the persistent predator Mycobacterium tuberculosis JC Sacchettini, EJ Rubin, JS Freundlich Nature Reviews Microbiology 6 (1), 41-52, 2008 | 327 | 2008 |
| Discovery of MRSA active antibiotics using primary sequence from the human microbiome J Chu, X Vila-Farres, D Inoyama, M Ternei, LJ Cohen, EA Gordon, ... Nature Chemical Biology 12 (12), 1004-1006, 2016 | 216 | 2016 |
| Enhanced respiration prevents drug tolerance and drug resistance in Mycobacterium tuberculosis C Vilchèze, T Hartman, B Weinrick, P Jain, TR Weisbrod, LW Leung, ... Proceedings of the National Academy of Sciences 114 (17), 4495-4500, 2017 | 192 | 2017 |
| Triclosan Derivatives: Towards Potent Inhibitors of Drug‐Sensitive and Drug‐Resistant Mycobacterium tuberculosis JS Freundlich, F Wang, C Vilchèze, G Gulten, R Langley, GA Schiehser, ... ChemMedChem: Chemistry Enabling Drug Discovery 4 (2), 241-248, 2009 | 187 | 2009 |
| Antituberculosis thiophenes define a requirement for Pks13 in mycolic acid biosynthesis R Wilson, P Kumar, V Parashar, C Vilchèze, R Veyron-Churlet, ... Nature chemical biology 9 (8), 499-506, 2013 | 164 | 2013 |
| Synthetic and Mechanistic Investigations of Trimethylsilyl-Substituted Triamidoamine Complexes of Tantalum That Contain Metal− Ligand Multiple Bonds JS Freundlich, RR Schrock, WM Davis Journal of the American Chemical Society 118 (15), 3643-3655, 1996 | 160 | 1996 |
| Non-classical transpeptidases yield insight into new antibacterials P Kumar, A Kaushik, EP Lloyd, SG Li, R Mattoo, NC Ammerman, DT Bell, ... Nature chemical biology 13 (1), 54-61, 2017 | 142 | 2017 |
| Open source Bayesian models. 1. Application to ADME/Tox and drug discovery datasets AM Clark, K Dole, A Coulon-Spektor, A McNutt, G Grass, JS Freundlich, ... Journal of chemical information and modeling 55 (6), 1231-1245, 2015 | 131 | 2015 |
| Structure-guided discovery of phenyl-diketo acids as potent inhibitors of M. tuberculosis malate synthase IV Krieger, JS Freundlich, VB Gawandi, JP Roberts, VB Gawandi, Q Sun, ... Chemistry & biology 19 (12), 1556-1567, 2012 | 131 | 2012 |
| The Natural Product Eugenol Is an Inhibitor of the Ebola Virus In Vitro T Lane, M Anantpadma, JS Freundlich, RA Davey, PB Madrid, S Ekins Pharmaceutical research 36, 1-6, 2019 | 114 | 2019 |
| Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 1: 4′-substituted … JS Freundlich, JW Anderson, D Sarantakis, HM Shieh, M Yu, ... Bioorganic & medicinal chemistry letters 15 (23), 5247-5252, 2005 | 110 | 2005 |
| Bayesian models leveraging bioactivity and cytotoxicity information for drug discovery S Ekins, RC Reynolds, H Kim, MS Koo, M Ekonomidis, M Talaue, ... Chemistry & biology 20 (3), 370-378, 2013 | 108 | 2013 |
| Comparing and Validating Machine Learning Models for Mycobacterium tuberculosis Drug Discovery T Lane, DP Russo, KM Zorn, AM Clark, A Korotcov, V Tkachenko, ... Molecular pharmaceutics 15 (10), 4346-4360, 2018 | 106 | 2018 |
| Computational databases, pathway and cheminformatics tools for tuberculosis drug discovery S Ekins, JS Freundlich, I Choi, M Sarker, C Talcott Trends in microbiology 19 (2), 65-74, 2011 | 100 | 2011 |
| Machine learning models identify molecules active against the Ebola virus in vitro S Ekins, JS Freundlich, AM Clark, M Anantpadma, RA Davey, P Madrid F1000Research 4, 1091, 2017 | 98 | 2017 |
| Organometallic complexes of tantalum that contain the triamidoamine ligand,[(Me3SiNCH2CH2) 3N] 3-, including an ethylidene complex formed via a phosphine-catalyzed … JS Freundlich, RR Schrock, CC Cummins, WM Davis Journal of the American Chemical Society 116 (14), 6476-6477, 1994 | 86 | 1994 |
| Novel Inhibitors of InhA Efficiently Kill Mycobacterium tuberculosis under Aerobic and Anaerobic Conditions C Vilcheze, AD Baughn, JA Tufariello, LW Leung, M Kuo, CF Basler, ... Antimicrobial agents and chemotherapy 55 (8), 3889-3898, 2011 | 85 | 2011 |
| A Novel Small-Molecule Inhibitor of the Mycobacterium tuberculosis Demethylmenaquinone Methyltransferase MenG Is Bactericidal to Both Growing and … P Sukheja, P Kumar, N Mittal, SG Li, E Singleton, R Russo, AL Perryman, ... MBio 8 (1), 10.1128/mbio. 02022-16, 2017 | 83 | 2017 |
