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James P. Garnett
James P. Garnett
Associate Lecturer, Institute of Cellular Medicine, Newcastle University, UK & Head of Respiratory Epithelial Barrier Research Lab, Boehringer Ingelheim, Germany
Bestätigte E-Mail-Adresse bei boehringer-ingelheim.com - Startseite
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Interleukin‐1 blockade inhibits the acute inflammatory response in patients with ST‐segment–elevation myocardial infarction
A Abbate, CR Trankle, LF Buckley, MJ Lipinski, D Appleton, D Kadariya, ...
Journal of the American Heart Association 9 (5), e014941, 2020
2272020
Airway surface liquid homeostasis in cystic fibrosis: pathophysiology and therapeutic targets
IJ Haq, MA Gray, JP Garnett, C Ward, M Brodlie
Thorax 71 (3), 284-287, 2016
1932016
Metformin reduces airway glucose permeability and hyperglycaemia-induced Staphylococcus aureus load independently of effects on blood glucose
JP Garnett, EH Baker, S Naik, JA Lindsay, GM Knight, S Gill, JS Tregoning, ...
Thorax 68 (9), 835-845, 2013
1202013
Novel role for pendrin in orchestrating bicarbonate secretion in cystic fibrosis transmembrane conductance regulator (CFTR)-expressing airway serous cells
JP Garnett, E Hickman, R Burrows, P Hegyi, L Tiszlavicz, AW Cuthbert, ...
Journal of Biological Chemistry 286 (47), 41069-41082, 2011
1162011
Increased airway glucose increases airway bacterial load in hyperglycaemia
SK Gill, K Hui, H Farne, JP Garnett, DL Baines, LSP Moore, AH Holmes, ...
Scientific reports 6 (1), 27636, 2016
1092016
Sweet talk: insights into the nature and importance of glucose transport in lung epithelium
JP Garnett, EH Baker, DL Baines
European Respiratory Journal 40 (5), 1269-1276, 2012
1092012
Delayed induction of type I and III interferons mediates nasal epithelial cell permissiveness to SARS-CoV-2
CF Hatton, RA Botting, ME Dueñas, IJ Haq, B Verdon, BJ Thompson, ...
Nature Communications 12 (1), 7092, 2021
1002021
Proinflammatory mediators disrupt glucose homeostasis in airway surface liquid
JP Garnett, TT Nguyen, JD Moffatt, ER Pelham, KK Kalsi, EH Baker, ...
The Journal of Immunology 189 (1), 373-380, 2012
782012
E-cigarette constituents propylene glycol and vegetable glycerin decrease glucose uptake and its metabolism in airway epithelial cells in vitro
M Woodall, J Jacob, KK Kalsi, V Schroeder, E Davis, B Kenyon, I Khan, ...
American Journal of Physiology-Lung Cellular and Molecular Physiology 319 (6 …, 2020
742020
Hyperglycaemia and Pseudomonas aeruginosa acidify cystic fibrosis airway surface liquid by elevating epithelial monocarboxylate transporter 2 dependent lactate-H+ secretion
JP Garnett, KK Kalsi, M Sobotta, J Bearham, G Carr, J Powell, M Brodlie, ...
Scientific reports 6 (1), 37955, 2016
712016
Elevated paracellular glucose flux across cystic fibrosis airway epithelial monolayers is an important factor for Pseudomonas aeruginosa growth
JP Garnett, MA Gray, R Tarran, M Brodlie, C Ward, EH Baker, DL Baines
PloS one 8 (10), e76283, 2013
702013
Metformin prevents the effects of Pseudomonas aeruginosa on airway epithelial tight junctions and restricts hyperglycaemia‐induced bacterial growth
WRA Patkee, G Carr, EH Baker, DL Baines, JP Garnett
Journal of cellular and molecular medicine 20 (4), 758-764, 2016
602016
Rationale and design of the Virginia Commonwealth University–Anakinra Remodeling Trial‐3 (VCU‐ART3): A randomized, placebo‐controlled, double‐blinded, multicenter study
BW Van Tassell, MJ Lipinski, D Appleton, CS Roberts, MC Kontos, ...
Clinical cardiology 41 (8), 1004-1008, 2018
562018
Development of a miniaturized 96-Transwell air–liquid interface human small airway epithelial model
T Bluhmki, S Bitzer, JA Gindele, E Schruf, T Kiechle, M Webster, ...
Scientific reports 10 (1), 13022, 2020
542020
Human lung fibroblast-to-myofibroblast transformation is not driven by an LDH5-dependent metabolic shift towards aerobic glycolysis
E Schruf, V Schroeder, CA Kuttruff, S Weigle, M Krell, M Benz, ...
Respiratory research 20, 1-10, 2019
452019
Recapitulating idiopathic pulmonary fibrosis related alveolar epithelial dysfunction in a human iPSC‐derived air‐liquid interface model
E Schruf, V Schroeder, HQ Le, T Schönberger, D Raedel, EL Stewart, ...
The FASEB Journal 34 (6), 7825-7846, 2020
442020
Dapagliflozin‐lowered blood glucose reduces respiratory Pseudomonas aeruginosa infection in diabetic mice
A Åstrand, C Wingren, A Benjamin, JS Tregoning, JP Garnett, H Groves, ...
British Journal of Pharmacology 174 (9), 836-847, 2017
392017
Fructose transport-deficient Staphylococcus aureus reveals important role of epithelial glucose transporters in limiting sugar-driven bacterial growth in airway …
JP Garnett, D Braun, AJ McCarthy, MR Farrant, EH Baker, JA Lindsay, ...
Cellular and Molecular Life Sciences 71, 4665-4673, 2014
372014
Effect of acute myocardial infarction on the utility of fractional flow reserve for the physiologic assessment of the severity of coronary artery narrowing
JC McClish, M Ragosta, ER Powers, KG Barringhaus, LW Gimple, ...
The American journal of cardiology 93 (9), 1102-1106, 2004
372004
Targeting uPA-uPAR interaction to improve intestinal epithelial barrier integrity in inflammatory bowel disease
Y Cheng, TR Hall, X Xu, I Yung, D Souza, J Zheng, F Schiele, M Hoffmann, ...
EBioMedicine 75, 2022
332022
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