| Somatic coding mutations in human induced pluripotent stem cells A Gore, Z Li, HL Fung, JE Young, S Agarwal, J Antosiewicz-Bourget, ... Nature 471 (7336), 63-67, 2011 | 1488 | 2011 |
| Inhibition of calpain cleavage of huntingtin reduces toxicity: accumulation of calpain/caspase fragments in the nucleus J Gafni, E Hermel, JE Young, CL Wellington, MR Hayden, LM Ellerby Journal of Biological Chemistry 279 (19), 20211-20220, 2004 | 412 | 2004 |
| Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease E Hermel, J Gafni, SS Propp, BR Leavitt, CL Wellington, JE Young, ... Cell Death & Differentiation 11 (4), 424-438, 2004 | 312 | 2004 |
| The presenilin-1 ΔE9 mutation results in reduced γ-secretase activity, but not total loss of PS1 function, in isogenic human stem cells G Woodruff, JE Young, FJ Martinez, F Buen, A Gore, J Kinaga, Z Li, ... Cell reports 5 (4), 974-985, 2013 | 211 | 2013 |
| Polyglutamine-expanded androgen receptor interferes with TFEB to elicit autophagy defects in SBMA CJ Cortes, HC Miranda, H Frankowski, Y Batlevi, JE Young, A Le, ... Nature neuroscience 17 (9), 1180-1189, 2014 | 195 | 2014 |
| Elucidating molecular phenotypes caused by the SORL1 Alzheimer’s disease genetic risk factor using human induced pluripotent stem cells JE Young, J Boulanger-Weill, DA Williams, G Woodruff, F Buen, ... Cell stem cell 16 (4), 373-385, 2015 | 187 | 2015 |
| Akt blocks ligand binding and protects against expanded polyglutamine androgen receptor toxicity I Palazzolo, BG Burnett, JE Young, PL Brenne, AR La Spada, ... Human molecular genetics 16 (13), 1593-1603, 2007 | 163 | 2007 |
| Nutrient deprivation induces neuronal autophagy and implicates reduced insulin signaling in neuroprotective autophagy activation JE Young, RA Martinez, AR La Spada Journal of Biological Chemistry 284 (4), 2363-2373, 2009 | 148 | 2009 |
| Depletion of the AD risk gene SORL1 selectively impairs neuronal endosomal traffic independent of amyloidogenic APP processing A Knupp, S Mishra, R Martinez, JE Braggin, M Szabo, C Kinoshita, ... Cell reports 31 (9), 2020 | 140 | 2020 |
| Defective transcytosis of APP and lipoproteins in human iPSC-derived neurons with familial Alzheimer’s disease mutations G Woodruff, SM Reyna, M Dunlap, R Van Der Kant, JA Callender, ... Cell reports 17 (3), 759-773, 2016 | 115 | 2016 |
| Proteolytic cleavage of ataxin-7 by caspase-7 modulates cellular toxicity and transcriptional dysregulation JE Young, L Gouw, S Propp, BL Sopher, J Taylor, A Lin, E Hermel, ... Journal of Biological Chemistry 282 (41), 30150-30160, 2007 | 111 | 2007 |
| Stabilizing the retromer complex in a human stem cell model of Alzheimer’s disease reduces TAU phosphorylation independently of amyloid precursor protein JE Young, LK Fong, H Frankowski, GA Petsko, SA Small, LSB Goldstein Stem cell reports 10 (3), 1046-1058, 2018 | 97 | 2018 |
| The Alzheimer’s gene SORL1 is a regulator of endosomal traffic and recycling in human neurons S Mishra, A Knupp, MP Szabo, CA Williams, C Kinoshita, DW Hailey, ... Cellular and Molecular Life Sciences 79 (3), 162, 2022 | 90 | 2022 |
| Polyglutamine-expanded androgen receptor truncation fragments activate a Bax-dependent apoptotic cascade mediated by DP5/Hrk JE Young, GA Garden, RA Martinez, F Tanaka, CM Sandoval, AC Smith, ... Journal of Neuroscience 29 (7), 1987-1997, 2009 | 74 | 2009 |
| Human microglia show unique transcriptional changes in Alzheimer’s disease KE Prater, KJ Green, S Mamde, W Sun, A Cochoit, CL Smith, KL Chiou, ... Nature Aging 3 (7), 894-907, 2023 | 72 | 2023 |
| Alzheimer's disease in a dish: promises and challenges of human stem cell models JE Young, LSB Goldstein Human molecular genetics 21 (R1), R82-R89, 2012 | 71 | 2012 |
| Full-length amyloid precursor protein regulates lipoprotein metabolism and amyloid-β clearance in human astrocytes LK Fong, MM Yang, R dos Santos Chaves, SM Reyna, VF Langness, ... Journal of Biological Chemistry 293 (29), 11341-11357, 2018 | 63 | 2018 |
| The role of Alzheimer's disease risk genes in endolysosomal pathways MP Szabo, S Mishra, A Knupp, JE Young Neurobiology of disease 162, 105576, 2022 | 56 | 2022 |
| Advances and current challenges associated with the use of human induced pluripotent stem cells in modeling neurodegenerative disease BJ Berry, AST Smith, JE Young, DL Mack Cells Tissues Organs 205 (5-6), 331-349, 2019 | 51 | 2019 |
| Alternative splicing in a presenilin 2 variant associated with Alzheimer disease JE Braggin, SA Bucks, MM Course, CL Smith, B Sopher, L Osnis, ... Annals of clinical and translational neurology 6 (4), 762-777, 2019 | 48 | 2019 |
