Mechanistic understanding of lanthipeptide biosynthetic enzymes LM Repka, JR Chekan, SK Nair, WA Van Der Donk Chemical reviews 117 (8), 5457-5520, 2017 | 502 | 2017 |
Xylan utilization in human gut commensal bacteria is orchestrated by unique modular organization of polysaccharide-degrading enzymes M Zhang, JR Chekan, D Dodd, PY Hong, L Radlinski, V Revindran, ... Proceedings of the National Academy of Sciences 111 (35), E3708-E3717, 2014 | 184 | 2014 |
Biosynthesis of the neurotoxin domoic acid in a bloom-forming diatom JK Brunson, SMK McKinnie, JR Chekan, JP McCrow, ZD Miles, ... Science 361 (6409), 1356-1358, 2018 | 167 | 2018 |
Genome mining methods to discover bioactive natural products KD Bauman, KS Butler, BS Moore, JR Chekan Natural Product Reports 38 (11), 2100-2129, 2021 | 121 | 2021 |
Discovery of a new ATP-binding motif involved in peptidic azoline biosynthesis KL Dunbar, JR Chekan, CL Cox, BJ Burkhart, SK Nair, DA Mitchell Nature chemical biology 10 (10), 823-829, 2014 | 103 | 2014 |
Guanitoxin, re-naming a cyanobacterial organophosphate toxin MF Fiore, ST de Lima, WW Carmichael, SMK McKinnie, JR Chekan, ... Harmful Algae 92, 101737, 2020 | 86 | 2020 |
Characterization of the macrocyclase involved in the biosynthesis of RiPP cyclic peptides in plants JR Chekan, P Estrada, PS Covello, SK Nair Proceedings of the National Academy of Sciences 114 (25), 6551-6556, 2017 | 67 | 2017 |
Scalable Biosynthesis of the Seaweed Neurochemical, Kainic Acid JR Chekan, SMK McKinnie, ML Moore, SG Poplawski, TP Michael, ... Angewandte Chemie 131 (25), 8542-8545, 2019 | 66 | 2019 |
Steric complementarity directs sequence promiscuous leader binding in RiPP biosynthesis JR Chekan, C Ongpipattanakul, SK Nair Proceedings of the National Academy of Sciences 116 (48), 24049-24055, 2019 | 51 | 2019 |
Biosynthesis of l‐4‐Chlorokynurenine, an Antidepressant Prodrug and a Non‐Proteinogenic Amino Acid Found in Lipopeptide Antibiotics H Luhavaya, R Sigrist, JR Chekan, SMK McKinnie, BS Moore Angewandte Chemie International Edition 58 (25), 8394-8399, 2019 | 44 | 2019 |
Molecular basis for resistance against phosphonate antibiotics and herbicides JR Chekan, DP Cogan, SK Nair MedChemComm 7 (1), 28-36, 2016 | 39 | 2016 |
Structure of the lasso peptide isopeptidase identifies a topology for processing threaded substrates JR Chekan, JD Koos, C Zong, MO Maksimov, AJ Link, SK Nair Journal of the American Chemical Society 138 (50), 16452-16458, 2016 | 37 | 2016 |
Biosynthesis of marine toxins JR Chekan, TR Fallon, BS Moore Current Opinion in Chemical Biology 59, 119-129, 2020 | 32 | 2020 |
Biosynthesis of guanitoxin enables global environmental detection in freshwater cyanobacteria ST Lima, TR Fallon, JL Cordoza, JR Chekan, E Delbaje, AR Hopiavuori, ... Journal of the American Chemical Society 144 (21), 9372-9379, 2022 | 27 | 2022 |
A common late-stage intermediate in catalysis by 2-hydroxyethyl-phosphonate dioxygenase and methylphosphonate synthase SC Peck, JR Chekan, EC Ulrich, SK Nair, WA Van Der Donk Journal of the American Chemical Society 137 (9), 3217-3220, 2015 | 27 | 2015 |
Domoic acid biosynthesis in the red alga Chondria armata suggests a complex evolutionary history for toxin production TS Steele, JK Brunson, Y Maeno, R Terada, AE Allen, M Yotsu-Yamashita, ... Proceedings of the National Academy of Sciences 119 (6), e2117407119, 2022 | 24 | 2022 |
Algal neurotoxin biosynthesis repurposes the terpene cyclase structural fold into an N-prenyltransferase JR Chekan, SMK McKinnie, JP Noel, BS Moore Proceedings of the National Academy of Sciences 117 (23), 12799-12805, 2020 | 23 | 2020 |
Structure and function of phosphonoacetaldehyde dehydrogenase: the missing link in phosphonoacetate formation V Agarwal, SC Peck, JH Chen, SA Borisova, JR Chekan, ... Chemistry & biology 21 (1), 125-135, 2014 | 23 | 2014 |
A widely distributed biosynthetic cassette is responsible for diverse plant side chain cross‐linked cyclopeptides ST Lima, BG Ampolini, EB Underwood, TN Graf, CE Earp, IC Khedi, ... Angewandte Chemie International Edition 62 (7), e202218082, 2023 | 22 | 2023 |
Molecular basis for enantioselective herbicide degradation imparted by aryloxyalkanoate dioxygenases in transgenic plants JR Chekan, C Ongpipattanakul, TR Wright, B Zhang, JM Bollinger Jr, ... Proceedings of the National Academy of Sciences 116 (27), 13299-13304, 2019 | 20 | 2019 |