| Tissue-specific oncogenic activity of KRASA146T EJ Poulin, AK Bera, J Lu, YJ Lin, SD Strasser, JA Paulo, TQ Huang, ... Cancer discovery 9 (6), 738-755, 2019 | 165* | 2019 |
| Translating preclinical models to humans DK Brubaker, DA Lauffenburger Science 367 (6479), 742-743, 2020 | 102 | 2020 |
| Proteogenomic network analysis of context-specific KRAS signaling in mouse-to-human cross-species translation DK Brubaker, JA Paulo, S Sheth, EJ Poulin, O Popow, BA Joughin, ... Cell systems 9 (3), 258-270. e6, 2019 | 51 | 2019 |
| Computational translation of genomic responses from experimental model systems to humans DK Brubaker, EA Proctor, KM Haigis, DA Lauffenburger PLoS computational biology 15 (1), e1006286, 2019 | 44 | 2019 |
| Integrated in vivo multiomics analysis identifies p21-activated kinase signaling as a driver of colitis J Lyons, DK Brubaker, PC Ghazi, KR Baldwin, A Edwards, M Boukhali, ... Science signaling 11 (519), eaan3580, 2018 | 37 | 2018 |
| Coagulopathy signature precedes and predicts severity of end‐organ heat stroke pathology in a mouse model EA Proctor, SM Dineen, SC Van Nostrand, MK Kuhn, CD Barrett, ... Journal of thrombosis and haemostasis 18 (8), 1900-1910, 2020 | 36 | 2020 |
| An interspecies translation model implicates integrin signaling in infliximab-resistant inflammatory bowel disease DK Brubaker, MP Kumar, EL Chiswick, C Gregg, A Starchenko, PN Vega, ... Science Signaling 13 (643), eaay3258, 2020 | 35 | 2020 |
| Substrate-based kinase activity inference identifies MK2 as driver of colitis SD Strasser, PC Ghazi, A Starchenko, M Boukhali, A Edwards, ... Integrative Biology 11 (7), 301-314, 2019 | 22 | 2019 |
| Drug intervention response predictions with PARADIGM (DIRPP) identifies drug resistant cancer cell lines and pathway mechanisms of resistance D Brubaker, A Difeo, Y Chen, T Pearl, K Zhai, G Bebek, M Chance, ... Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing, 125, 2014 | 22 | 2014 |
| Vaginal epithelial dysfunction is mediated by the microbiome, metabolome, and mTOR signaling AR Berard, DK Brubaker, K Birse, A Lamont, RD Mackelprang, ... Cell Reports 42 (5), 2023 | 19 | 2023 |
| Integrated microRNA and mRNA network analysis of the human myometrial transcriptome in the transition from quiescence to labor WE Ackerman IV, IA Buhimschi, D Brubaker, S Maxwell, KM Rood, ... Biology of Reproduction 98 (6), 834-845, 2018 | 19 | 2018 |
| Finding lost genes in GWAS via integrative—omics analysis reveals novel sub-networks associated with preterm birth D Brubaker, Y Liu, J Wang, H Tan, G Zhang, B Jacobsson, L Muglia, ... Human Molecular Genetics 25 (23), 5254-5264, 2016 | 18 | 2016 |
| A dynamical systems model of progesterone receptor interactions with inflammation in human parturition D Brubaker, A Barbaro, M R. Chance, S Mesiano BMC systems biology 10, 1-14, 2016 | 18 | 2016 |
| Computational interspecies translation between Alzheimer’s disease mouse models and human subjects identifies innate immune complement, TYROBP, and TAM receptor agonist … MJ Lee, C Wang, MJ Carroll, DK Brubaker, BT Hyman, DA Lauffenburger Frontiers in Neuroscience 15, 727784, 2021 | 12 | 2021 |
| Clostridioides difficile-Associated Antibiotics Alter Human Mucosal Barrier Functions by Microbiome-Independent Mechanisms JC Kester, DK Brubaker, J Velazquez, C Wright, DA Lauffenburger, ... Antimicrobial agents and chemotherapy 64 (4), 10.1128/aac. 01404-19, 2020 | 12 | 2020 |
| Engineering logical inflammation sensing circuit for gut modulation LN Merk, AS Shur, A Pandey, RM Murray, LN Green bioRxiv 10 (2020.11), 10.377085, 2020 | 8 | 2020 |
| Differential responses of primary neuron-secreted MCP-1 and IL-9 to type 2 diabetes and Alzheimer’s disease-associated metabolites BK Ball, MK Kuhn, RM Fleeman Bechtel, EA Proctor, DK Brubaker Scientific reports 14 (1), 12743, 2024 | 7 | 2024 |
| Endogenous production of hyaluronan, PRG4, and cytokines is sensitive to cyclic loading in synoviocytes M Pendyala, PS Woods, DK Brubaker, EA Blaber, TA Schmidt, DD Chan Plos one 17 (12), e0267921, 2022 | 7 | 2022 |
| Frequent subgraph mining of personalized signaling pathway networks groups patients with frequently dysregulated disease pathways and predicts prognosis A Durmaz, TAD Henderson, D Brubaker, G Bebek PACIFIC SYMPOSIUM ON BIOCOMPUTING 2017, 402-413, 2017 | 4 | 2017 |
| Cross-species transcriptomic signatures predict response to MK2 inhibition in mouse models of chronic inflammation L Suarez-Lopez, B Shui, DK Brubaker, M Hill, A Bergendorf, ... Iscience 24 (12), 2021 | 3 | 2021 |