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Chrisostomos Prodromou
Chrisostomos Prodromou
Senior Research Fellow, University of Sussex
Bestätigte E-Mail-Adresse bei sussex.ac.uk
Titel
Zitiert von
Zitiert von
Jahr
Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone
C Prodromou, SM Roe, R O'Brien, JE Ladbury, PW Piper, LH Pearl
Cell 90 (1), 65-75, 1997
16621997
Structure and mechanism of the Hsp90 molecular chaperone machinery
LH Pearl, C Prodromou
Annu. Rev. Biochem. 75 (1), 271-294, 2006
13972006
Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin
SM Roe, C Prodromou, R O'Brien, JE Ladbury, PW Piper, LH Pearl
Journal of medicinal chemistry 42 (2), 260-266, 1999
12551999
Crystal structure of an Hsp90–nucleotide–p23/Sba1 closed chaperone complex
MMU Ali, SM Roe, CK Vaughan, P Meyer, B Panaretou, PW Piper, ...
Nature 440 (7087), 1013-1017, 2006
11792006
ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivo
B Panaretou, C Prodromou, SM Roe, R O'Brien, JE Ladbury, PW Piper, ...
The EMBO journal 17 (16), 4829-4836, 1998
9441998
Activation of the ATPase activity of hsp90 by the stress-regulated cochaperone aha1
B Panaretou, G Siligardi, P Meyer, A Maloney, JK Sullivan, S Singh, ...
Molecular cell 10 (6), 1307-1318, 2002
6642002
The ATPase cycle of Hsp90 drives a molecular ‘clamp’via transient dimerization of the N‐terminal domains
C Prodromou, B Panaretou, S Chohan, G Siligardi, R O'Brien, JE Ladbury, ...
The EMBO journal, 2000
6532000
Structural and functional analysis of the middle segment of hsp90: implications for ATP hydrolysis and client protein and cochaperone interactions
P Meyer, C Prodromou, B Hu, C Vaughan, SM Roe, B Panaretou, ...
Molecular cell 11 (3), 647-658, 2003
6142003
Regulation of Hsp90 ATPase activity by tetratricopeptide repeat (TPR)‐domain co‐chaperones
C Prodromou, G Siligardi, R O'Brien, DN Woolfson, L Regan, B Panaretou, ...
The EMBO journal, 1999
5631999
NVP-AUY922: a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis
SA Eccles, A Massey, FI Raynaud, SY Sharp, G Box, M Valenti, ...
Cancer research 68 (8), 2850-2860, 2008
5572008
The Hsp90 molecular chaperone: an open and shut case for treatment
LH Pearl, C Prodromou, P Workman
Biochemical Journal 410 (3), 439-453, 2008
5522008
4, 5-diarylisoxazole Hsp90 chaperone inhibitors: potential therapeutic agents for the treatment of cancer
PA Brough, W Aherne, X Barril, J Borgognoni, K Boxall, JE Cansfield, ...
Journal of medicinal chemistry 51 (2), 196-218, 2008
5262008
Chaperoned ubiquitylation—crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex
M Zhang, M Windheim, SM Roe, M Peggie, P Cohen, C Prodromou, ...
Molecular cell 20 (4), 525-538, 2005
4772005
Structure and in vivo function of Hsp90
LH Pearl, C Prodromou
Current opinion in structural biology 10 (1), 46-51, 2000
4492000
The mechanism of Hsp90 regulation by the protein kinase-specific cochaperone p50cdc37
SM Roe, MMU Ali, P Meyer, CK Vaughan, B Panaretou, PW Piper, ...
Cell 116 (1), 87-98, 2004
4322004
Structural basis for recruitment of the ATPase activator Aha1 to the Hsp90 chaperone machinery
P Meyer
The EMBO journal 23 (6), 1402-1410, 2004
4132004
Recursive PCR: a novel technique for total gene synthesis
C Prodromou, LH Pearl
Protein Engineering, Design and Selection 5 (8), 827-829, 1992
3861992
Structure and functional relationships of Hsp90
C Prodromou, LH Pearl
Current cancer drug targets 3 (5), 301-323, 2003
3692003
Structure of an hsp90-cdc37-cdk4 complex
CK Vaughan, U Gohlke, F Sobott, VM Good, MMU Ali, C Prodromou, ...
Molecular cell 23 (5), 697-707, 2006
3612006
Regulation of Hsp90 ATPase activity by the co-chaperone Cdc37p/p50cdc37
G Siligardi, B Panaretou, P Meyer, S Singh, DN Woolfson, PW Piper, ...
Journal of biological chemistry 277 (23), 20151-20159, 2002
3452002
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