Effect of KRAS Oncogene Substitutions on Protein Behavior: Implications for Signaling and Clinical Outcome NT Ihle, LA Byers, ES Kim, P Saintigny, JJ Lee, GR Blumenschein, A Tsao, ... Journal of the National Cancer Institute 104 (3), 228-239, 2012 | 605 | 2012 |
Polypharmacology: drug discovery for the future AS Reddy, S Zhang Expert review of clinical pharmacology 6 (1), 41-47, 2013 | 544 | 2013 |
Mechanisms and clinical activity of an EGFR and HER2 exon 20–selective kinase inhibitor in non–small cell lung cancer JP Robichaux, YY Elamin, Z Tan, BW Carter, S Zhang, S Liu, S Li, T Chen, ... Nature medicine 24 (5), 638-646, 2018 | 480 | 2018 |
Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression CH Chan, JK Morrow, CF Li, Y Gao, G Jin, A Moten, LJ Stagg, JE Ladbury, ... Cell 154 (3), 556-568, 2013 | 414 | 2013 |
First-pass metabolism via UDP-glucuronosyltransferase: a barrier to oral bioavailability of phenolics B Wu, K Kulkarni, S Basu, S Zhang, M Hu Journal of pharmaceutical sciences 100 (9), 3655-3681, 2011 | 352 | 2011 |
A ROR1–HER3–lncRNA signalling axis modulates the Hippo–YAP pathway to regulate bone metastasis C Li, S Wang, Z Xing, A Lin, K Liang, J Song, Q Hu, J Yao, Z Chen, ... Nature cell biology 19 (2), 106-119, 2017 | 303 | 2017 |
A novel automated lazy learning QSAR (ALL-QSAR) approach: method development, applications, and virtual screening of chemical databases using validated ALL-QSAR models S Zhang, A Golbraikh, S Oloff, H Kohn, A Tropsha Journal of chemical information and modeling 46 (5), 1984-1995, 2006 | 270 | 2006 |
Rho kinases play an obligatory role in vertebrate embryonic organogenesis L Wei, W Roberts, L Wang, M Yamada, S Zhang, Z Zhao, SA Rivkees, ... Oxford University Press for The Company of Biologists Limited 128 (15), 2953 …, 2001 | 263 | 2001 |
Transcription factors ETS2 and MESP1 transdifferentiate human dermal fibroblasts into cardiac progenitors JF Islas, Y Liu, KC Weng, MJ Robertson, S Zhang, A Prejusa, J Harger, ... Proceedings of the National Academy of Sciences 109 (32), 13016-13021, 2012 | 239 | 2012 |
Syndecan 1 is a critical mediator of macropinocytosis in pancreatic cancer W Yao, JL Rose, W Wang, S Seth, H Jiang, A Taguchi, J Liu, L Yan, ... Nature 568 (7752), 410-414, 2019 | 179 | 2019 |
Small molecule compounds targeting miRNAs for cancer therapy PC Monroig, L Chen, S Zhang, GA Calin Advanced drug delivery reviews 81, 104-116, 2015 | 175 | 2015 |
The critical role of AMPK in driving Akt activation under stress, tumorigenesis and drug resistance F Han, CF Li, Z Cai, X Zhang, G Jin, WN Zhang, C Xu, CY Wang, J Morrow, ... Nature communications 9 (1), 4728, 2018 | 168 | 2018 |
Targeting microRNAs with small molecules: from dream to reality S Zhang, L Chen, EJ Jung, GA Calin Clinical Pharmacology & Therapeutics 87 (6), 754-758, 2010 | 160 | 2010 |
Conditional mutagenesis of the murine serum response factor gene blocks cardiogenesis and the transcription of downstream gene targets Z Niu, W Yu, SX Zhang, M Barron, NS Belaguli, MD Schneider, ... Journal of Biological Chemistry 280 (37), 32531-32538, 2005 | 159 | 2005 |
Serum response factor micromanaging cardiogenesis Z Niu, A Li, SX Zhang, RJ Schwartz Current opinion in cell biology 19 (6), 618-627, 2007 | 152 | 2007 |
DOVIS: an implementation for high-throughput virtual screening using AutoDock S Zhang, K Kumar, X Jiang, A Wallqvist, J Reifman BMC bioinformatics 9, 1-4, 2008 | 143 | 2008 |
Extracellular glutamate is increased in thalamus during thiamine deficiency‐induced lesions and is blocked by MK‐801 PJ Langlais, SX Zhang Journal of neurochemistry 61 (6), 2175-2182, 1993 | 129 | 1993 |
Computational prediction of protein hot spot residues J Kenneth Morrow, S Zhang Current pharmaceutical design 18 (9), 1255-1265, 2012 | 128 | 2012 |
Development of Quantitative Structure− Binding Affinity Relationship Models Based on Novel Geometrical Chemical Descriptors of the Protein− Ligand Interfaces S Zhang, A Golbraikh, A Tropsha Journal of medicinal chemistry 49 (9), 2713-2724, 2006 | 123 | 2006 |
EZH2 engages TGFβ signaling to promote breast cancer bone metastasis via integrin β1-FAK activation L Zhang, J Qu, Y Qi, Y Duan, YW Huang, Z Zhou, P Li, J Yao, B Huang, ... Nature communications 13 (1), 2543, 2022 | 119 | 2022 |