| Artificial miRNAs mitigate shRNA-mediated toxicity in the brain: implications for the therapeutic development of RNAi JL McBride, RL Boudreau, SQ Harper, PD Staber, AM Monteys, I Martins, ... Proceedings of the National Academy of Sciences 105 (15), 5868-5873, 2008 | 734 | 2008 |
| Artificial microRNAs as siRNA shuttles: improved safety as compared to shRNAs in vitro and in vivo RL Boudreau, I Martins, BL Davidson Molecular Therapy 17 (1), 169-175, 2009 | 446 | 2009 |
| Nonallele-specific silencing of mutant and wild-type huntingtin demonstrates therapeutic efficacy in Huntington's disease mice RL Boudreau, JL McBride, I Martins, S Shen, Y Xing, BJ Carter, ... Molecular Therapy 17 (6), 1053-1063, 2009 | 417 | 2009 |
| Preclinical safety of RNAi-mediated HTT suppression in the rhesus macaque as a potential therapy for Huntington's disease JL McBride, MR Pitzer, RL Boudreau, B Dufour, T Hobbs, SR Ojeda, ... Molecular Therapy 19 (12), 2152-2162, 2011 | 320 | 2011 |
| Mitoregulin: a lncRNA-encoded microprotein that supports mitochondrial supercomplexes and respiratory efficiency CS Stein, P Jadiya, X Zhang, JM McLendon, GM Abouassaly, NH Witmer, ... Cell reports 23 (13), 3710-3720. e8, 2018 | 242 | 2018 |
| Transcriptome-wide discovery of microRNA binding sites in human brain RL Boudreau, P Jiang, BL Gilmore, RM Spengler, R Tirabassi, JA Nelson, ... Neuron 81 (2), 294-305, 2014 | 232 | 2014 |
| Silencing of CDK5 reduces neurofibrillary tangles in transgenic alzheimer's mice D Piedrahita, I Hernández, A López-Tobón, D Fedorov, B Obara, ... Journal of Neuroscience 30 (42), 13966-13976, 2010 | 222 | 2010 |
| Inhibition of MCU forces extramitochondrial adaptations governing physiological and pathological stress responses in heart TP Rasmussen, Y Wu, MA Joiner, OM Koval, NR Wilson, ED Luczak, ... Proceedings of the National Academy of Sciences 112 (29), 9129-9134, 2015 | 188 | 2015 |
| Minimizing variables among hairpin-based RNAi vectors reveals the potency of shRNAs RL Boudreau, AM Monteys, BL Davidson Rna 14 (9), 1834-1844, 2008 | 184 | 2008 |
| RNA interference suppresion of neurodegenerative diseases and methods of use thereof B Davidson, H Xia, Q Mao, H Paulson, R Boudreau US Patent App. 10/859,751, 2005 | 145 | 2005 |
| Silencing mutant ATXN3 expression resolves molecular phenotypes in SCA3 transgenic mice E Rodríguez-Lebrón, M doCarmo Costa, K Luna-Cancalon, TM Peron, ... Molecular Therapy 21 (10), 1909-1918, 2013 | 122 | 2013 |
| Control of hepatic nuclear superoxide production by glucose 6-phosphate dehydrogenase and NADPH oxidase-4 NY Spencer, Z Yan, RL Boudreau, Y Zhang, M Luo, Q Li, X Tian, AM Shah, ... Journal of Biological Chemistry 286 (11), 8977-8987, 2011 | 115 | 2011 |
| Rational design of therapeutic siRNAs: minimizing off-targeting potential to improve the safety of RNAi therapy for Huntington's disease RL Boudreau, RM Spengler, BL Davidson Molecular Therapy 19 (12), 2169-2177, 2011 | 101 | 2011 |
| RNAi medicine for the brain: progresses and challenges RL Boudreau, E Rodríguez-Lebrón, BL Davidson Human molecular genetics 20 (R1), R21-R27, 2011 | 98 | 2011 |
| Broad therapeutic benefit after RNAi expression vector delivery to deep cerebellar nuclei: implications for spinocerebellar ataxia type 1 therapy MS Keiser, RL Boudreau, BL Davidson Molecular Therapy 22 (3), 588-595, 2014 | 89 | 2014 |
| A microRNA processing defect in smokers' macrophages is linked to SUMOylation of the endonuclease DICER TJ Gross, LS Powers, RL Boudreau, B Brink, A Reisetter, K Goel, ... Journal of Biological Chemistry 289 (18), 12823-12834, 2014 | 88 | 2014 |
| RNA interference suppression of neurodegenerative diseases and methods of use thereof BL Davidson, H Xia, Q Mao, H Paulson, R Boudreau, S Harper US Patent 8,481,710, 2013 | 84 | 2013 |
| Sirtuin 1 regulates cardiac electrical activity by deacetylating the cardiac sodium channel A Vikram, CM Lewarchik, JY Yoon, A Naqvi, S Kumar, GM Morgan, ... Nature medicine 23 (3), 361-367, 2017 | 77 | 2017 |
| siSPOTR: a tool for designing highly specific and potent siRNAs for human and mouse RL Boudreau, RM Spengler, RH Hylock, BJ Kusenda, HA Davis, ... Nucleic acids research 41 (1), e9-e9, 2013 | 76 | 2013 |
| RNA interference: a tool for querying nervous system function and an emerging therapy BL Davidson, RL Boudreau Neuron 53 (6), 781-788, 2007 | 76 | 2007 |
