| Histone deacetylase 10 structure and molecular function as a polyamine deacetylase Y Hai, SA Shinsky, NJ Porter, DW Christianson Nature communications 8 (1), 15368, 2017 | 193 | 2017 |
| Unusual zinc-binding mode of HDAC6-selective hydroxamate inhibitors NJ Porter, A Mahendran, R Breslow, DW Christianson Proceedings of the National Academy of Sciences 114 (51), 13459-13464, 2017 | 167 | 2017 |
| Structure, mechanism, and inhibition of the zinc-dependent histone deacetylases NJ Porter, DW Christianson Current opinion in structural biology 59, 9-18, 2019 | 112 | 2019 |
| Synthesis and biological investigation of phenothiazine-based benzhydroxamic acids as selective histone deacetylase 6 inhibitors K Vögerl, N Ong, J Senger, D Herp, K Schmidtkunz, M Marek, M Müller, ... Journal of medicinal chemistry 62 (3), 1138-1166, 2019 | 106 | 2019 |
| Histone deacetylase 6-selective inhibitors and the influence of capping groups on hydroxamate-zinc denticity NJ Porter, JD Osko, D Diedrich, T Kurz, JM Hooker, FK Hansen, ... Journal of medicinal chemistry 61 (17), 8054-8060, 2018 | 92 | 2018 |
| Binding of the microbial cyclic tetrapeptide trapoxin A to the class I histone deacetylase HDAC8 NJ Porter, DW Christianson ACS chemical biology 12 (9), 2281-2286, 2017 | 76 | 2017 |
| Entropy as a driver of selectivity for inhibitor binding to histone deacetylase 6 NJ Porter, FF Wagner, DW Christianson Biochemistry 57 (26), 3916-3924, 2018 | 59 | 2018 |
| Biocatalytic carbene transfer using diazirines NJ Porter, E Danelius, T Gonen, FH Arnold Journal of the American Chemical Society 144 (20), 8892-8896, 2022 | 49 | 2022 |
| Structural aspects of HDAC8 mechanism and dysfunction in Cornelia de Lange syndrome spectrum disorders MA Deardorff, NJ Porter, DW Christianson Protein Science 25 (11), 1965-1976, 2016 | 46 | 2016 |
| Exploring structural determinants of inhibitor affinity and selectivity in complexes with histone deacetylase 6 JD Osko, NJ Porter, PA Narayana Reddy, YC Xiao, J Rokka, M Jung, ... Journal of medicinal chemistry 63 (1), 295-308, 2019 | 42 | 2019 |
| Structural and Functional Influence of the Glycine-Rich Loop G302GGGY on the Catalytic Tyrosine of Histone Deacetylase 8 NJ Porter, NH Christianson, C Decroos, DW Christianson Biochemistry 55 (48), 6718-6729, 2016 | 34 | 2016 |
| Design and synthesis of dihydroxamic acids as HDAC6/8/10 inhibitors M Morgen, RR Steimbach, M Géraldy, L Hellweg, P Sehr, J Ridinger, ... ChemMedChem 15 (13), 1163-1174, 2020 | 29 | 2020 |
| Molecular basis for the selective inhibition of histone deacetylase 6 by a mercaptoacetamide inhibitor NJ Porter, S Shen, C Barinka, AP Kozikowski, DW Christianson ACS Medicinal Chemistry Letters 9 (12), 1301-1305, 2018 | 29 | 2018 |
| MicroED structure of a protoglobin reactive carbene intermediate E Danelius, NJ Porter, J Unge, FH Arnold, T Gonen Journal of the American Chemical Society 145 (13), 7159-7165, 2023 | 23 | 2023 |
| Chemodivergent C(sp3)–H and C(sp2)–H cyanomethylation using engineered carbene transferases J Zhang, AO Maggiolo, E Alfonzo, R Mao, NJ Porter, NM Abney, ... Nature catalysis 6 (2), 152-160, 2023 | 15 | 2023 |
| Aza-proline effectively mimics L-proline stereochemistry in triple helical collagen AJ Kasznel, T Harris, NJ Porter, Y Zhang, DM Chenoweth Chemical Science 10 (29), 6979-6983, 2019 | 13 | 2019 |
| A combinatorially complete epistatic fitness landscape in an enzyme active site KE Johnston, PJ Almhjell, EJ Watkins-Dulaney, G Liu, NJ Porter, J Yang, ... Proceedings of the National Academy of Sciences 121 (32), e2400439121, 2024 | 11 | 2024 |
| Iron Heme Enzyme-Catalyzed Cyclopropanations with Diazirines as Carbene Precursors: Computational Explorations of Diazirine Activation and Cyclopropanation Mechanism T Rogge, Q Zhou, NJ Porter, FH Arnold, KN Houk Journal of the American Chemical Society 146 (5), 2959-2966, 2024 | 11 | 2024 |
| The β-subunit of tryptophan synthase is a latent tyrosine synthase PJ Almhjell, KE Johnston, NJ Porter, JL Kennemur, VC Bhethanabotla, ... Nature Chemical Biology, 1-8, 2024 | 10 | 2024 |
| Structural analysis of histone deacetylase 8 mutants associated with Cornelia de Lange Syndrome spectrum disorders JD Osko, NJ Porter, C Decroos, MS Lee, PR Watson, SE Raible, ID Krantz, ... Journal of structural biology 213 (1), 107681, 2021 | 7 | 2021 |